Share this page!

Enter URL or ID to Unroll

You can paste full URL like: https://x.com/threadreaderapp/status/1644127596119195649
or just the ID like: 1644127596119195649

How to get URL link on X (Twitter) App

  1. On the Twitter thread, click on or icon on the bottom
  2. Click again on or Share Via icon
  3. Click on Copy Link to Tweet
  4. Paste it above and click "Unroll Thread"!
  5. More info at Twitter Help
Daniel Park Profile picture
@Daniel_E_Park
Sep 19 • 5 tweets • 2 min read Twitter logo Read on Twitter
Many EU agencies are excited about the updated Novavax vaccine. Germany just confirmed purchase of 10.6 million doses for this fall, 3 million in Italy. Europe has run large RCTs comparing vaccines showing benefits of heterologous boosting with AZ and NVX
corriere.it/politica/23_se…
These RCTs have shown tremendous benefits with heterologous boosting not only with immunologic endpoints, but more importantly with durability and protection from breakthrough infections (~9x better protection vs. homologous mRNA)

nejm.org/doi/full/10.10…
journalofinfection.com/article/S0163-…
Adding on the lower reactogenicity (side effects) of the Novavax platform, the cost-benefit advantages of NVX helps explain the growing international interest in the product.
x.com/Daniel_E_Park/…
For example, Taiwan for example has shifted primarily to Novavax

taipeitimes.com/News/taiwan/ar…
Image
All COVID vaccines have been critically important in saving lives during the pandemic. As cost-benefit becomes increasingly important during the endemic phase (see recent ACIP meeting), I see a larger role for platforms with lower reactogenicity and longer durability such as NVX.

• • •

Missing some Tweet in this thread? You can try to force a refresh
　

Keep Current with Daniel Park

Daniel Park Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @Daniel_E_Park

Daniel Park Profile picture
Sep 2
Recently released immunogenicity results from a Phase 3 RCT of the original Novavax vaccine when used as a booster. Good safety profile and excellent immune responses regardless of prior vaccine platform, even against Omicron BA.1 and BA.5
sciencedirect.com/science/articl…
Immune responses suggest booster shots provide protection that exceed the 87% efficacy based on correlates of protection established in a previous study
nature.com/articles/s4146…
The findings also suggest that the Novavax booster is especially beneficial for those who had homologous (i.e. same platform) mRNA schedules previously: "NVX-CoV2373-induced IgG seroconversion may be higher when given after a homologous primary and booster mRNA regimen"
Read 7 tweets
Daniel Park Profile picture
Aug 8
Helpful results to inform the strategy behind annual COVID-19 vaccines. Good durability and efficacy (>80%) against hospitalization over 10 months with AstraZeneca (ChAdOx1).

https://t.co/9hFKVLiEBosciencedirect.com/science/articl…
Image
Comparatively, mRNA efficacy vs hospitalization wanes ~50%-80% by the fourth month after vaccination:

https://t.co/hntIoJhpbx
And significant waning vs. infection:
https://t.co/w6bsK0lSIibmj.com/content/379/bm…
cdc.gov/mmwr/volumes/7…
nature.com/articles/s4146…
Some of this may be confounded by emerging variants (with mRNA being more specific to only the target variant), since other studies show longer efficacy.
jamanetwork.com/journals/jamao…
Read 5 tweets
Daniel Park Profile picture
Jul 31
RCT of Covovax / Novavax COVID vaccine in children 2-11y and 12-17y. Excellent immune responses across variants that had higher titers than adults. Also very low rate of side effects, with no myocarditis reported.
jamanetwork.com/journals/jamap…
This figure shows excellent antibody responses in both adolescents and children through at least 6 months. Many vaccine platforms have differential responses by age, but the adjuvant (Matrix-M) may be helping responses across the age spectrum. Image
Case in point: There were also excellent responses in older ages in this comparative effectiveness study from Korea - showing the breadth and robustness of the immune responses with the adjuvanted NVX platform.
medrxiv.org/content/10.110…
Read 4 tweets
Daniel Park Profile picture
Jun 1
This WaPo article serves as a reminder that having multiple vax platforms is important. mRNA vaccines are great, but newer doesn't necessarily equal better. Cuba achieved broad coverage and strong protection with a protein vaccine (similar tech to Novavax)
washingtonpost.com/opinions/2023/…
Although the vaccine took a bit longer to develop, by the end of Sep 2021, they achieved >80% coverage. A remarkable achievement. Image
Let's see what impact this had on infections. During the initial parts of the Delta wave (mid-2021) Cuba was faring worse than the US, but by Sep we see a sharp decline. Omicron was barely a blip, and they have near-zero transmission ever since. Image
Read 8 tweets
Daniel Park Profile picture
May 16
Important study of Novavax (ancestral & BA.1) and Moderna boosters in primates. All have effective long-term immune responses and lower viral replication, but only NVX had significantly lower viral loads in upper airways, which could limit transmission. science.org/doi/10.1126/sc…
Panel E shows some of the mRNA-1273 boosted NHPs with similar upper airway viral loads to controls, whereas the viral loads are much lower (or non-detectable) after Novavax boost, with significance shown using AUCs in panel F. Image
A key note is that the viral challenge was 3-months post-boost, indicating strong protection during periods of waning immunity. There is also some interesting data on IgG class switching, VOCs, and also notably lung pathology was comparably milder among NVX boosted macaques.
Read 4 tweets
Daniel Park Profile picture
May 15
Preprint of NVX-CoV2373 immunogenicity outcomes by age and HIV status. Very high seroconversion rates (i.e. protection) in all groups (98.3% for younger and 94.3% for older adults), regardless of age and HIV status.
medrxiv.org/content/10.110…
This is important in context of immunosenescence and higher risk of severe disease in older adults, which is well characterized for all vaccines, including mRNA.

ncbi.nlm.nih.gov/pmc/articles/P…
nature.com/articles/s4358…
Adjuvanted vaccines (as used with Novavax) often help with the response in older adults. More direct studies needed but initial estimates suggest comparable (or perhaps improved) efficacy in older individuals using adjuvanted NVX vs mRNA
Read 4 tweets

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us on Twitter!

Send Email!

:(