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Nov 10 5 tweets 1 min read Twitter logo Read on Twitter
SARS-CoV-2 infection leads to catastrophic confusion in cellular communication 🧵

We’re talking about significant surges in antibodies against critical G-protein coupled receptors.

And it’s affecting young adults recovering from COVID.

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The presence of elevated antibodies against G-protein coupled receptors—key molecular switches that orchestrate a multitude of physiological processes including cardiac function, neurotransmission, and vascular regulation—poses a serious threat.

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These antibodies can mistakenly activate or block these receptors, causing a systemic disarray in the body's signaling pathways.

The result is a cascade of malfunctions.

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The heart may beat erratically, blood pressure can fluctuate wildly, and other essential bodily functions may go awry.

This biological turmoil can translate into chronic conditions, severely diminishing quality of life and posing a long-term burden on health systems.

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More from @outbreakupdates

Nov 7
In plain talk.

In controlled laboratory environments, SARS-CoV-2 demonstrates relentless genomic plasticity.

It’s accruing mutations with a propensity for enhancing viral fitness.

1/ Image
These genetic shifts (some ephemeral, others stabilizing in) suggest a non-random evolutionary trajectory.

Kinda optimizing the virus for increased transmissibility and evasion of host immune mechanisms.

It’s not just adapting.

2/
In this study, researchers took nine strains, some labeled as significant threats, and let them multiply in a controlled setting, observing them for up to 100 generations.

3/
Read 6 tweets
Nov 3
ORF7a: The Key to Host Cell Invasion

The autophagy-lysosome pathway is a vital immune defense mechanism.

SARS-CoV-2 exploits our cellular machinery to its advantage.

1/ Image
Human cells are like a high-tech security vaults.

They have advanced intruder detection systems.

The autophagy-lysosome pathways detect and break down invaders like viruses.

2/
Autophagy is also like a cell's recycling system

Like a room that cleans itself by identifying and packing up broken furniture into boxes & then transforming them into brand new items

Autophagy breaks down damaged cell parts and recycles them to create new, functional ones

3/
Read 6 tweets
Oct 30
Eyes don’t lie 🧵

The eyes of Long COVID patients show significant nerve damage.

They display notable nerve degradation.

Their corneal nerve fibers are sparser, branching is stunted, and the nerve lengths are curtailed.

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The complex network of corneal nerves in the human eye is like a spiderweb.

Within the elegant structure of this web, each silken thread represents a delicate neural pathway, connected to maintain stability and harmony.

2/
This web is specifically designed to optimize its function – catching insects – just as the corneal nerves are designed to relay sensory information efficiently.

3/
Read 13 tweets
Oct 29
Your brain is a forest 🌳

In a particular part of this forest, there are trees (dopamine-producing cells) vital for our movement and feelings of pleasure and reward.

The sudden appearance of the SARS-CoV-2 virus is like an unexpected spark in this forest.

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The virus’s spike, particularly the S1 domain, is the arsonist’s torch.

As it infiltrates, it targets the cell’s mitochondria.

They are the forest’s groundwater reservoirs.

2/
This dysfunction is like cutting off the forest’s essential water channels, setting the cellular environment into a dry and vulnerable state.
3/
Read 11 tweets
Oct 25
Your brain is a mirror 🪞

SARS-CoV-2 is a hammer 🔨

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Envision your brain as an elaborate, mirror designed to reflect your mental, sensory, and emotional experiences.

Now imagine a hammer—labeled 'post-COVID headaches'—smashing that mirror into a web of fractures.

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This is no superficial crack.

We're talking about shattering essential regions of the brain like the temporal, sensorimotor, and insular areas.

3/
Read 7 tweets
Oct 24
Long covid is a wildfire scorching healthcare funds 🔥🧵

In a healthcare landscape already marred by pandemics and chronic diseases, LC is the cataclysmic firestorm that makes everything else look like a campfire.

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SARS-CoV-2 isn’t a fire that emergency services can contain.

It’s a blazing inferno that devours everything in its path.

2/
From 2020 to 2023, LC’s spread led to a relentless increase in healthcare use across all categories:

📌general practitioners
📌outpatient services
📌inpatient facilities
📌emergency departments

3/
Read 8 tweets

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