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Hybrid immunity not protective, may worsen risk of infection
48-fold increased risk of getting a repeat Omicron infection among those who had prior Omicron infection
Large study from McMaster University Canada on vaccinated older adults, includes immune response details👇
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48-fold increased risk of getting a repeat Omicron infection among those who had prior Omicron infection
Large study from McMaster University Canada on vaccinated older adults, includes immune response details👇
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Study was done from July to September 2022, when Canada was going through a 2nd Omicron wave. They wanted to find out who was at greater risk of getting a 2nd omicron infection. Surprisingly, authors found that those who had prior omicron infection where are FAR GREATER risk.
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The value of the study is that they meticulously measured antibody and T cell response of a large no. of older adults. They did not find any relation with age, frailty or comorbidity.
The paper must be kept as a reference on how immune systems work in older people.
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The paper must be kept as a reference on how immune systems work in older people.
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They found that immune response was not the same among all participants. Authors argue that lower antibody levels might be a reason for getting reinfected. It is not due to underlying immunosuppression, they find.
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thelancet.com/journals/eclin…
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thelancet.com/journals/eclin…
Although done in older adults, the study challenges the existing dogma that hybrid immunity is the way out of the pandemic.
More infections do not mean better immunity.
❗️The study also shows that time since last dose of vaccine did not affect infection risk.
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More infections do not mean better immunity.
❗️The study also shows that time since last dose of vaccine did not affect infection risk.
5/5
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