Eric Feigl-Ding Profile picture
Nov 22, 2023 21 tweets 9 min read Read on X
⚠️UNDIAGNOSED PNEUMONIA OUTBREAK—An emerging large outbreak of pneumonia in China, with pediatric hospitals in Beijing, Liaoning overwhelmed with sick children, & many schools suspended. Beijing Children's Hospital overflowing. 🧵on what we know so far:
2) An alert 🔔 went out on ProMed epidemic network last night. They warn of an unknown “walking pneumonia” without coughing, but HIGH FEVER + pulmonary nodules. Hospital’s full of kids now on IV drips.



Chinese report
promedmail.org/promed-post/?i…
ftvnews.com.tw/news/detail/20…
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3) Some school classes have even been canceled completely. Not only are all students sick, but teachers are also infected with pneumonia. ...

Mr. [W], a Beijing citizen: "Now you are not allowed to report to school. If you have any symptoms such as fever, cold, cough and then you are hospitalized”
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4) “It is too early to project whether this could be another pandemic but as a wise influenza virologist once said to me "The pandemic clock is ticking, we just do not know what time it is."”
5) Also of note- Beijing and Liaoning are 800 km apart!! This epidemic isn’t localized anymore. That worries me a lot. 🤔

Chinese hospitals have been “overwhelmed with sick children” as an outbreak of pneumonia escalates in cities across the country.
telegraph.co.uk/global-health/…
6) In an editor’s note, ProMed said: “This report suggests a widespread outbreak of an undiagnosed respiratory illness ... It is not at all clear when this outbreak started as it would be unusual for so many children to be affected so quickly.“ — this is worrisome too.
7) one speculation—outbreak could be a type of Mycoplasma pneumoniae, aka “walking pneumonia”, reportedly surging in China. ➡️But this is a vague lumping. We don’t know the infectious agent. And this is not typical “walking pneumonia” since this new outbreak is not mild.
8) Let this photo sink in— students in China keep doing homework in the hospital while getting IV fluids.

What a world. Image
9) The pneumonia started surging
in October… doctors noted also that:

“Compared to previous years, we found more patients with mixed infections, **drug resistance**.”

Maybe it’s a new virus or it’s maybe it’s a nasty antibiotic-resistant bacteria.
chinadaily.com.cn/a/202310/24/WS…
10) Here are direct reports from the scene on Chinese from locals— I’ll try to provide excerpts from this conversation…

=====
So there was no movement for a whole hour after No. 406, and the parents couldn't bear it.
Call the police. The police are here. They understand the situation and go to another hospital.
Triage, triage is not moving, Children’s Hospital is no longer treating children.
The institute is also full of people. These parents are from the institute and children
The hospital didn't call me.
02:00
This is the current overall situation, and we all should consider it together
judge.
02:01
02:00
01:50
The situation is indeed difficult, not only for the hospital, but also for the patients and the police.
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11) “Disaster. I had a chat with an older brother, who is a student in the third year of junior high school in No. 35 Middle School.
She is a 15-year-old girl. She has had a fever for 2 days and has been cooling down physically. See
I was looking at the textbook and suddenly fainted. The emergency department came to the hospital for help.”
Image
12) “It's an emergency. A child has been having a high fever and it can't be brought down even by taking antipyretics.
Go down, face red, a little boy
01:52
Basically half of the children who go to school have fever and [pneumonia].” Image
13) “01:55
If you haven’t come to the hospital, you may not be able to imagine the severity.
Basically, the medical system is at its lowest point, and every hospital is empty of people.
Well, the final solution given by the police was to report it to Xicheng District first
The government coordinates the solution, and the second oldest children over 14 years old are divided into
He went to the emergency room of Peking University Hospital and went through the procedures for adult medical treatment.
01:59
At present, children’s hospitals and pediatric research institutes are basically unable to get admission
No., the pediatric emergency department of Friendship Hospital requires waiting for more than 24 hours.”
Image
14) The respiratory department at Vietnam's children's hospital (HCMC) has run out of beds, forcing patients to lie in hammocks in the hallway. Video via @trongnhan9500

@trongnhan9500 15) Is it mild? I’m not so sure. But this worries me— “One-tenth of the patients come from out of town … because bronchoscopies are unavailable in their hometown.” ➡️According to Chinese CDC, bronchoscopies are not needed for mild cases of the infection.”
sixthtone.com/news/1014131
@trongnhan9500 16) China’s official news outlet blames the outbreak on “Influenza, adenovirus, RSV, rhinovirus”,… but says something further. They don’t acknowledge any unknown source of the outbreak… is it just those 3 viruses, or coverup of something else? 🤔 Image
@trongnhan9500 17) there has been a reported rise in influenza A (brown) and discussions of flu and many other viruses on Chinese Weibo (WeChat). Not sure if it’s the cause of this surge, but worrisome… trying my best to find clues what it is…

whatsonweibo.com/sick-kids-worr…
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18) China is a place of extremes for emergence of outbreaks and what it can do to a society. Last winter, after dust settled, experts estimated 2-3 million people died when COVID mitigations were dropped. It was thermonuclear bad. Hope this winter won’t be the same.
19) This graph showing a sudden spike in H9N2 was provided by @EPIWATCH_bsp, an AI-driven system that scans for signals worldwide. And their system found an uptick in avian H9N2 reports in China that stick out in the last 2 weeks. @CIDRAP also notes an case of H9N2 in a HK report.

EpiWatch founder @Globalbiosec notes that:

“A google search in English will only give you a fraction of what is out there. our early research on Asian languages showed you will miss most reports if you do not search in specific disease and syndrome terms in original languages. Over 70% of our intel is NOT in English.”

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@EPIWATCH_bsp @CIDRAP 20) I pray it’s not an avian flu that jumped to humans. We will know more in the coming days. I’ll keep folks updated. Meantime, please SUBSCRIBE (for free, no paywall) for updates later. Thank you:
drericding.substack.com/subscribe
@EPIWATCH_bsp @CIDRAP 21) the WHO has made an official request to China for more data on the unknown pneumonia outbreak. But while their post is vague, the WHO summary is clearly worried to make their demand to China 🇨🇳 public. It suggest the situation of my thread 🧵 above is very real…

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More from @DrEricDing

Feb 26
BREAKING—FDA suddenly cancels meeting to update next season’s flu vaccines, with zero explanations. Any delays will jeopardize next year’s vaccine supply chain. Image
2) Folks who follow me know that I’m no bullshitter. I criticized past pandemic response right and left, and have called balls and strikes without bias. And I often say things that doctors & epidemiologists are whispering among themselves but don’t say publicly. (Cough cough) ⬇️
3) While I don’t recommend hoarding… I think stocking up on flu antivirals, which you can obtain prophylactically (preventively) from doctors if you ask nicely why you’re high risk, can be a good idea. I know many doctors, epidemiologists and virologists who do for their family.
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Feb 26
Doctors are debunking RFK Jr’s claim that 20 hospitalized measles cases in Texas are there for mainly quarantine. Doctors on the ground say the 20 kids hospitalized are having trouble breathing. Oh and they are all unvaccinated against measles, which RFK Jr neglects to mention. Image
2) RFK Jr told Trump today there’s now 2 measles deaths.
3) RFK Jr is a tear with his FDA today. A dark Darwinian future lies ahead for America.
Read 4 tweets
Feb 26
BREAKING—Reports coming in about potentially *2 measles deaths* in Texas, not just one, according to an HHS briefing to the White House today.
2) Earlier today, one measles death in an unvaccinated child was reported in Texas. Image
3) It seems to be RFK Jr who said it in an official Trump WH cabinet meeting today. Not saying he doesn’t lie, but he is now HHS Secretary
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Feb 21
Woke or biology? There are actually more than the basic “male” XY & “female” XX sexes. Why? Because biology also creates people with single X chromosomes, or extra chromosomes like XXX, XXY, XYY, or XXX+, plus many 🧬genes. 👉All I’m asking is— please be kind to others. Thanks🙏 Image
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2) “The most frequent SCAs include Turner syndrome (45,X), Klinefelter syndrome (47,XXY), Trisomy X syndrome (47,XXX), and Double Y syndrome (47,XYY).”

pmc.ncbi.nlm.nih.gov/articles/PMC10…
3) “The phenotype seen in SCAs is highly variable and may not merely be due to the direct genomic imbalance from altered sex chromosome gene dosage but also due to additive alterations in gene networks and regulatory pathways across the genome as well as individual genetic modifiers.”
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Feb 16
I'm shocked a lot of doctors don't know about this newer flu antiviral drug called Baloxavir (XOFLUZA)... that shortens your flu illness by 33%, and reduces your viral load by day 2, versus what a placebo takes 5-6 days to achieve. Baloxavir also seems superior to TAMIFLU (oseltamivir) for smashing your viral load on 2 day, achieving what takes Tamiflu 3-4 days. CDC even lists Baloxavir on their website as one of the top 4 drugs that it tracks whether it works against new flu strains (it works)Image
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2) "Baloxavir was associated with significantly more rapid declines in infectious viral load than placebo or oseltamivir (Figure 3A and 3B)."
nejm.org/doi/full/10.10…
3) Adverse events for baloxavir were no different than placebo. in fact theres even hints that it could be lower than Tamiflu.

"Adverse events that were considered to be related to the trial regimen were more common in oseltamivir recipients (8.4%) than in baloxavir recipients (4.4%, P=0.009)"Image
Read 13 tweets
Feb 14
⚠️WORST FLU SEASON ever since 2002-2003 when we began to track flu (red, first graph). Worst hit this year are children ages 0-4 and 5-17. ▶️We also have significantly LOWER flu vaccine uptake this year, one of the lowest flu vaccine coverages (red 3rd graph). Indisputable facts. Image
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2) I don't need to tell you that certain US states have vastly lower vaccination rates than others. See map (lighter green, less flu vaccination coverage), and which have higher (darker green)...

If you want to see details and demographics on which state has the LOWEST flu vaccine coverage rates... the data is here.
cdc.gov/fluvaxview/das…Image
3) It’s not just the flu that is going around… Gaines County, TX, where the epicenter of the measles outbreak is, has one of the lowest measles vaccination rates too.
Read 7 tweets

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