Dr. Sean Mullen Profile picture
Dec 2, 2023 4 tweets 5 min read Read on X
I asked ChatGPT to predict the future based on a novel virus that parallels the outcomes associated with SARS-CoV-2 (but I omitted the name to avoid misinformation). Remember, GPT aced medical exams and there are only a handful of people who’ve been screaming from the rooftops about these possibilities…

Here’s DrHouseGPT’s 🔮 thoughts:

Given the scenario where the novel virus has significantly compromised immune systems, similar to severe immunodeficiency disorders, several specific infections might emerge or re-emerge. Here's a list of potential infections to watch out for:
Respiratory Infections:
•Bacterial Pneumonias: Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus could cause more severe infections.
•Viral Respiratory Infections: Influenza, parainfluenza, and other common respiratory viruses could lead to more complications.
Opportunistic Infections:
•Fungal Infections: Candidiasis and Pneumocystis jirovecii pneumonia (PCP), particularly in severely immunocompromised individuals.
•Mycobacterial Infections: Tuberculosis and non-tuberculous mycobacterial infections could see a significant rise.
Gastrointestinal Infections:
•Bacterial infections like Salmonella, Shigella, and Campylobacter, which can cause severe gastroenteritis.
•Viral infections like Norovirus, which might lead to more severe and prolonged symptoms.
Neurological Infections:
•Viruses such as West Nile Virus or enteroviruses could cause more severe encephalitis or meningitis.
•Progressive multifocal leukoencephalopathy (PML), a rare brain infection caused by the JC virus, could occur in severely immunosuppressed individuals.
Skin and Soft Tissue Infections:
•Increased incidence of severe skin infections caused by common bacteria like Staphylococcus aureus (including MRSA) or Streptococcus pyogenes.
Reactivation of Latent Viruses:
•Herpesviruses, including cytomegalovirus (CMV), Epstein-Barr virus (EBV), and Varicella-zoster virus (VZV), could reactivate and cause severe disease.
Sexually Transmitted Infections (STIs):
•Higher susceptibility and severity of STIs, including HIV, syphilis, and herpes simplex virus.
Parasitic Infections:
•Toxoplasmosis and other parasitic infections might become more common, especially in regions where they are endemic.
In addition to these infections, there could be a general increase in the severity and duration of typically self-limiting or minor infections. It's crucial in this scenario to enhance surveillance, infection control, and public health measures to mitigate the impact of these infections.
Then I asked it:

This is an incredibly horrible scenario DrHouseGPT. Can you tell me what the best mitigations should be in this scenario if we know this novel virus is principally transmitted through aerosolized particulates? Is seems to infect people in the air within as little as 2 minutes of exposure. What could we possibly do to stop this thing and prevent what feels like an extinction level event?

Response:

In a scenario with a highly contagious virus transmitted through aerosolized particles with such a rapid rate of infection, aggressive and multi-faceted mitigation strategies are essential to prevent what could indeed be a catastrophic public health crisis. Here are the key strategies:

Universal Masking: Mandate high-quality masks (N95, KN95, or FFP2/3 standards) in all public spaces, especially indoors and in crowded areas. This would significantly reduce the transmission of aerosolized particles.
Enhanced Ventilation and Air Filtration: Upgrade ventilation systems in buildings to include HEPA filters. Encourage outdoor activities over indoor gatherings. Portable air purifiers can also be used in settings where ventilation upgrades are not feasible.
Rapid and Widespread Testing: Implement widespread testing with rapid turnaround times to quickly identify and isolate infected individuals. Regular testing in schools, workplaces, and other high-density areas can help in early detection.
Contact Tracing and Quarantine Protocols: Efficient contact tracing and strict quarantine measures for those exposed to the virus are critical to contain outbreaks.
Vaccine Development and Distribution: Fast-track the development and distribution of an effective vaccine against the virus. Ensure global access to vaccination, particularly in high-risk areas.
Public Education Campaigns: Educate the public on the seriousness of the virus, modes of transmission, and the importance of following public health guidelines.
Travel Restrictions and Screening: Implement travel restrictions or mandatory quarantine for travelers from high-risk areas. Increase screening procedures at entry points like airports and train stations.
Personal Hygiene Measures: Promote rigorous personal hygiene practices, including frequent handwashing and use of hand sanitizers, especially in public places.
Social Distancing Measures: Implement social distancing in public spaces, workplaces, and schools to reduce close contact and potential transmission.
Research and Development: Invest in research to understand the virus better, including its mutations, and develop effective treatments.
Healthcare System Strengthening: Increase the capacity of healthcare systems to handle a surge in patients, including more hospital beds, ventilators, and trained healthcare workers.
Global Cooperation: Foster global cooperation for sharing resources, information, and best practices to combat the virus effectively.
This approach combines public health measures, scientific research, and community engagement. Swift and decisive action, along with international collaboration, would be key to preventing an extinction-level event.
Upon request by a few folks in this thread, I prompted it to tell me how much time we might have left…

Timeline Estimation: Estimating a specific timeline like 5 years or a decade for human survival under these conditions is speculative. However, without effective mitigation and in the presence of a continuously spreading lethal virus, the situation could become critical within a few years. The impact would not only be in terms of direct mortality from the virus but also from the collapse of healthcare systems, disruption of supply chains, and breakdown of societal structures.
Me: Can you help me explain the psychology of humans while this is happening and dissect the barriers they might have connecting science with reality? For example, how could we get more people to see each independent outbreak as connected to the mass immune system deficiencies?

DrHouseGPT: Understanding the psychology behind human responses to widespread health crises and the challenges in connecting scientific understanding with public perception is a complex but crucial aspect of managing such situations. Here are some key psychological factors and strategies for bridging the gap between science and public perception:

1. **Cognitive Dissonance**: People often experience discomfort when new information conflicts with their existing beliefs. This can lead to denial or rejection of scientific facts that are perceived as threatening.

2. **Confirmation Bias**: Individuals tend to favor information that confirms their preconceptions, regardless of whether the information is true. This can make it difficult to accept new scientific findings that contradict their beliefs.

3. **Information Overload**: In the digital age, people are bombarded with information, including misinformation. This overload can lead to confusion and difficulty discerning reliable information.

4. **Emotional Responses**: Fear, anxiety, and grief can overpower rational thought, leading to impulsive decisions or resistance to changing behavior based on scientific advice.

5. **Distrust in Authorities**: Mistrust in governmental or scientific institutions can lead to skepticism about public health messages and scientific data.

To address these barriers and help people connect outbreaks to the broader issue of immune system deficiencies, consider the following strategies:

- **Clear and Consistent Communication**: Use clear, understandable language to explain scientific concepts. Consistency in messaging is key to building trust and understanding.

- **Engage Trusted Community Leaders**: People often trust information from community or religious leaders, local healthcare providers, or peers more than distant authorities. Engaging these leaders in disseminating information can be effective.

- **Tailor Messaging**: Different groups may need different messaging strategies. Tailoring messages to resonate with specific audiences can increase their effectiveness.

- **Address Misinformation**: Actively combat misinformation by providing factual, science-based information and debunking false claims.

- **Use of Analogies and Stories**: People relate better to stories and analogies than to abstract concepts. Using them to explain the interconnectedness of outbreaks and immune deficiencies can be powerful.

- **Highlight Personal Impact**: Show how the issue directly affects individuals and their communities. Personal stories of those affected can be more impactful than statistics.

- **Empathy and Understanding**: Recognize the emotional and psychological states of your audience. Messages that acknowledge their fears and concerns can be more effective than those that simply present facts.

- **Involve the Public in Solutions**: Engaging the public in discussions about solutions can make them feel part of the process and more likely to accept scientific realities.

Ultimately, the goal is to create a narrative that connects with people's experiences, values, and emotions, while steadily providing accurate, science-based information. This requires a multi-faceted approach that considers the diverse psychological factors at play.

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More from @drseanmullen

Dec 26, 2024
COVID-19 may be reshaping young brains. A study of 94 college students revealed:
•40% reported ‘brain fog.’
•37% had measurable cognitive issues up to 17 months post-infection.
•Brain scans showed patterns resembling adults 40 years older.
What does this mean for brain health? 🧠
How they studied it:
Researchers used neuropsych tests and brain imaging (near-infrared spectroscopy or NIRS) to measure cognitive function and blood flow in the prefrontal cortex—key for decision-making and focus.
Findings? COVID survivors showed altered blood flow and more “brain effort” during tasks.
The cognitive issues mostly affected executive functions like task-switching and self-control.
•COVID+ students’ brain scans showed patterns similar to those of much older adults.
•Some compensated better than others, but nearly 40% showed lasting deficits.
This was up to 17 months post-infection.
Read 6 tweets
Oct 30, 2024
I’m still motivated to spread the word about the dangers of unmitigated SARS2 & I have endless reasons, but I decided to ask ChatGPT for 101 reasons. The response really surprised me, especially the last one.

Here it is:

Absolutely. Here are 101 reasons why you should continue spreading the word about the long-term health and societal consequences of unmitigated SARS-CoV-2 spread:

1. Protect your future health
2. Preserve cognitive functioning
3. Prevent Long COVID
4. Curb chronic illness
5. Safeguard public health
6. Keep hospitals from overcrowding
7. Maintain a healthy workforce
8. Ensure future surgeries are safe
9. Combat pandemic fatigue
10. Reduce healthcare costs
11. Protect young minds
12. Enable a healthy aging population
13. Reduce disability rates
14. Preserve mental health
15. Prevent dementia
16. Protect friendships and relationships
17. Avoid another pandemic
18. Defend immune-compromised individuals
19. Safeguard teachers
20. Prevent generational trauma
21. Enable safer communities
22. Lower burden on caregivers
23. Preserve national security
24. Prevent childhood long-term health issues
25. Protect pregnancy health
26. Preserve healthcare access
27. Reduce mental fog
28. Encourage scientific progress
29. Enable ongoing medical care
30. Reduce stigma around chronic illness
31. Ensure a healthy workforce for future generations
32. Promote informed decisions
33. Prevent workplace absenteeism
34. Support the economy
35. Promote healthier social gatherings
36. Avoid systemic collapse
37. Ensure future vaccine development
38. Limit environmental impacts
39. Protect the most vulnerable
40. Avoid isolation
41. Stop loss of life potential
42. Combat misinformation
43. Prevent worker burnout
44. Empower individuals
45. Ensure quality education
46. Preserve global stability
47. Reduce future health crises
48. Preserve human dignity
49. Prevent mass disability
50. Limit organ damage
51. Prevent systemic inflammation
52. Enable future athletic competitions
53. Prevent brain damage
54. Combat fatigue
55. Ensure economic recovery
56. Preserve mental sharpness
57. Protect artistic and creative communities
58. Enable safer travel
59. Prevent job loss
60. Promote longevity
61. Protect people’s hopes and dreams
62. Fight systemic inequity
63. Preserve childhood play
64. Reduce caregiver burnout
65. Promote vaccine equity
66. Prevent silent suffering
67. Stop heart disease
68. Support frontline workers
69. Protect food supply chains
70. Ensure responsible political leadership
71. Prevent irreversible lung damage
72. Enable future breakthroughs
73. Preserve family stability
74. Reduce insurance premiums
75. Ensure healthy sports teams
76. Protect mental well-being
77. Limit neurological decline
78. Prevent strokes
79. Reduce strain on emergency services
80. Keep schools open safely
81. Protect personal freedoms
82. Prevent financial strain
83. Promote physical fitness
84. Prevent community spread
85. Enable safe elder care
86. Preserve religious and spiritual gatherings
87. Protect small businesses
88. Prevent autoimmune diseases
89. Reduce medication dependency
90. Protect reproductive health
91. Prevent liver damage
92. Combat rising healthcare costs
93. Preserve the arts and culture
94. Ensure military readiness
95. Promote global solidarity
96. Protect future generations
97. Empower advocacy
98. Support long COVID research
99. Foster empathy
100. Prevent mass grieving
101. Stay human
101. Stay human—ultimately, continuing to spread the word is about caring for others and fighting for a world where health and well-being are prioritized.
100. Prevent mass grieving—the loss of life and health is devastating to families and communities.
Read 102 tweets
Sep 15, 2024
Our children are silently facing the threat of COVID every day—breathing air in schools and daycares that could carry this airborne virus. This isn’t just a cold. Multiple COVID infections can lead to lifelong problems—heart issues, cognitive decline, and diseases that we usually see in seniors, not in kids. Imagine your child battling illnesses in their 20s that we only expect in someone’s 70s. It’s time to take a stand. Demand cleaner air in schools. Educate your community. Call your Congressperson today and fight for our children’s future.
Read 4 tweets
Jun 11, 2024
The only doctors who they put on TV are the ones so deeply entrenched in Don’t Look Up channels of nonsense, that they can’t break free from their own messaging. They’ll discredit themselves & all those who rose to fame pushing political messaging rather than health science.🧵
No one on our side looks completely comfortable talking freely.

Guests aren’t invited to fill in all the gaps.

They are invited to connect one meaningless dot at a time.

At this rate, segments embody the slowness of the public brain and their above average synaptic distance.
This is why I refer to TV as the life-sucking machine.

The screen represents only those things they want you to see.

Your life is limited by the time you spend watching your constrained dreams in balance with living your self-regulated streams.
Read 4 tweets
Jun 1, 2024
Most people think cognitive dysfunction just means slowness, forgetfulness, and general thinking problems. But SARS-CoV-2 🧠damage can lead to loss of self-control and even violence. I've been ⚠️worried about this since the pandemic began, and if you look closely, you'll see it everywhere.
Pro tennis might not seem like the best example to illustrate population-level loss of inhibition control. Historically, it’s a “rich kids’ sport,” and when these players don’t get their way, they lash out like toddlers with the mouths of drunken sailors (e.g., McEnroe). The sexist coverage has often overlooked male tantrums while vilifying women for similar behavior. But that’s another discussion...
I've always admired Johnny Mac's fighting spirit and his incredible touch, but growing up, his temper turned me off. I had similar feelings about Nick Kyrgios. His on-court behavior is just as inexcusable. And now, this? This is shameful. 😡tennisworldusa.org/tennis/news/Te…
Read 5 tweets
May 4, 2024
Managing SARS-CoV-2-induced Brain Fog 😶‍🌫️

A recent review in Neurological Sciences by Gorenshtein et al. (2024) covers the efficacy of various treatments for brain fog triggered by SARS-CoV-2.

My takeaways:

1. Combination of Palmitoylethanolamide (PEA) and Luteolin:
- PEA: Functions by engaging cannabinoid receptors both directly and indirectly, making it an alternative if CBD and THC are restricted in your area. As a neuroinflammation antagonist within the N-acylethanolamine family, PEA has been shown to down-regulate TNF alpha and modulate mast cells.
- Luteolin: Known for its anti-inflammatory, antioxidant, and cytoprotective properties.

2. Non-Invasive Brain Stimulation:
- Used for decades, these techniques are backed by rigorously designed experimental studies, including sham-controlled trials:
- Transcranial Direct Current Stimulation (tDCS)
- Transcranial Magnetic Stimulation (TMS)

3. Hyperbaric Oxygen Therapy:
- Particularly notable is a sham-controlled RCT involving 37 participants in the treatment group, which showed moderately strong improvements in cognitive outcomes. These results correlated with MRI evidence of enhanced perfusion and microstructural changes, alongside clinical improvements in pain and sleep quality.

These therapeutic approaches offer promising avenues for symptom management in patients experiencing cognitive challenges following SARS-CoV-2 infection.
HBOT trial cited herein

nature.com/articles/s4159…
Here’s another one on HBOT

doi.org/10.7861/clinme…
Read 4 tweets

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