Thread by @AmandaKvalsvig

If some propose that children's immune systems were harmed in 2020 by spending time in minimal/no contact with others, they should apply testable hypotheses and data in support.
eg, Children have always lived on remote islands & farms, isolated for weeks/months at a time.
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https://twitter.com/lisa_iannattone/status/1730800968999079992

1. What types of immune dysfunction are they at risk of and how do these effects manifest in health data? The list from AlKhater shows what you would measure.
And ask the flying doctors. Are country children known for being particularly sickly?

2/5 ncbi.nlm.nih.gov/pmc/articles/P…

2. If remote children move to a town/mainland (eg, for schooling) they encounter infections that are new to them. Do they suddenly start getting more serious illness than other children? How many years would you expect the immunity debt to continue? Again, measurable in data.
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From my pov, my prev clinical experience + research reading suggest that for children living in remote places but otherwise materially comfortable, social isolation is def a challenge for them & distance from hospital can be a worry in an emergency. But not really infections.
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So with certain children living in more intense & more prolonged isolation than Covid lockdowns and decades of health data available, why was 'immunity debt' not described until 2021?
Why didn't we see this issue before Covid arrived?
The onus is on its proponents to explain.
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