HIV-1 (the most common type of human immunodeficiency virus) and SARS-CoV-2 "target the respective endothelial and hematopoietic stem-progenitor cells to thrive upon the relevant host cellular surrounded stromal microenvironments by adopting reciprocally-driven mechanistic routes..
HIV-1 utilizes the CD4+ T-lymphocyte receptor thereby advancing pathogenesis indirectly to the CD34+ HSPC (hematopoietic stem-progenitor cells).
SARS-CoV-2 directly targets the CD133+ ESPC (endothelial stem-progenitor cells) via ACE2 receptor causing cytokine storms of the CD4+ T-lymphocytes.
In this manner, these two viruses cause and extend their damage to the other cellular sub/types coexisting in the host cellular microenvironments..
putative miRNA molecules may be involved in the SARS-CoV-2-induced pathogenesis of the CD133+ ESPC in an epigenetic regulatory mechanism of the miRNA-targeted messenger RNAs (mRNA) of the T- or B-lymphocytes..
These cells, in turn, produce not only excessively impaired immune responses but also cause potentially lethal or long-lasting heart and lung damage in virus-infected individuals or patients."
SARS-CoV-2 is a gentle-looking cousin of HIV.
'Contrasting mechanistic susceptibilities of hematopoietic and endothelial stem-progenitor cells in respective pathogeneses of HIV-1 and SARS-CoV-2 infections'
HIV-1 utilizes the CD4+ T-lymphocyte receptor thereby advancing pathogenesis indirectly to the CD34+ HSPC (hematopoietic stem-progenitor cells).
SARS-CoV-2 directly targets the CD133+ ESPC (endothelial stem-progenitor cells) via ACE2 receptor causing cytokine storms of the CD4+ T-lymphocytes.
In this manner, these two viruses cause and extend their damage to the other cellular sub/types coexisting in the host cellular microenvironments..
putative miRNA molecules may be involved in the SARS-CoV-2-induced pathogenesis of the CD133+ ESPC in an epigenetic regulatory mechanism of the miRNA-targeted messenger RNAs (mRNA) of the T- or B-lymphocytes..
These cells, in turn, produce not only excessively impaired immune responses but also cause potentially lethal or long-lasting heart and lung damage in virus-infected individuals or patients."
SARS-CoV-2 is a gentle-looking cousin of HIV.
'Contrasting mechanistic susceptibilities of hematopoietic and endothelial stem-progenitor cells in respective pathogeneses of HIV-1 and SARS-CoV-2 infections'
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