Thread by @PetousisH

Some anti-science folk appear convinced that the Pfizer mRNA COVID-19 vaccine is causing Guillain Barre Syndrome (GBS). They claim I have lied and then they lost their shit when I said it does not. Let’s look at some evidence. 1/10

2/10 First let’s state their hypothesis “Pfizer mRNA COVID-19 vaccine is causing Guillain Barre Syndrome (GBS)”

3/10 Then we can frame a research question “Does administration of the mRNA COVID-19 vaccine increase the risk of the onset of GBS?” Keep in mid this condition is very rare, here are the background rates for different countries. globalvaccinedatanetwork.org/Data-Dashboard…

4/ 10 Now we can look at the risk of GBS both with and without exposure to the Pfizer vaccine and also other brands. The self-controlled case series (SCCS) method or similar is probably the best approach. Here are the results of some of these studies:

5/10 SCCS study from Italy looking at multiple different covid-19 vaccines and GBS among ~16million persons. Risk for GBS was increased after viral vector and Moderna but not after Pfizer mRNA vaccines. medrxiv.org/content/10.110…

6/10 SCCS study from England in over 17million persons. Viral vector vaccine associated with increased risk of GBS, Pfizer mRNA vaccine associated with no increased risk of GBS. sciencedirect.com/science/articl…

7/10 SCCS study from Denmark in 1.7million persons looking at the bivalent Omicron mRNA formulation. No increased risk of GBS. medrxiv.org/content/10.110…

8/10 Prospective surveillance study from South Korea on over 35million doses of viral vector and mRNA vaccines. Overall incidence post vaccine 1.42/million. After viral vector incidence
4.49/million, after mRNA 0.8/million nature.com/articles/s4159…

9/10 Nested case control study from Israel in a cohort of over 3million patients looking at GBS associated with infection and vaccine. Infection increased risk with odds ratio of over 6, mRNA vaccine DECREASED risk. neurology.org/doi/abs/10.121…

10/10 There is more but point made. So, given the body of evidence on the table to date about Pfizer mRNA covid-19 vaccine and GBS, had I agreed that the vaccine caused GBS, then I would have lied, because I was aware of this research that said otherwise.