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Daniele Focosi, MD PhD MSc Profile picture
@dfocosi
Dec 18, 2023 • 5 tweets • 2 min read • Read on X
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DEC 18 UPDATE ‼️Spike convergent evolution in the skyrocketing #Pirola descendant JN.1* (including XDD and XDK recombinant) + 🧵
@yunlong_cao @RajlabN @PeacockFlu @MarionKoopmans @jbloom_lab @SystemsVirology @SolidEvidence @BarouchLab @sigallab @GuptaR_lab @BenjMurrell @EricTopol Image
DEC 18 UPDATE ‼️ Spike convergent evolution in FLip’s Image
Not to forget: Spike convergent evolution in BA.1+BA.2 (where #Pirola and XBB come from) Image
Not to forget: Spike convergent evolution in XBB* Image
Spike convergent evolution in BA.4+BA.5 Image

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More from @dfocosi

Daniele Focosi, MD PhD MSc Profile picture
Jan 5
‼️Does the updated XBB.1.5 vaccine protects against the SARS-CoV-2 variant JN.1 ? A short🧵
@EricTopol @kakape @ewencallaway @DrEricDing @PeterHotez @jbloom_lab @BenjMurrell @RajlabN @LongDesertTrain @PeacockFlu @siamosolocani @ACasadevall1 @MarionKoopmans @RobiVil
JN.1 is the fittest descendant of BA.2.86*, the “Pirola clan” as named by @TRyanGregory Image
At first @yunlong_cao used JN.1-pseudotyped VSV to show that sera from (BA.5+XBB)- or XBB-infected subjects poorly neutralize infection of Huh-7 cells (mean titers 65 and 24), & that JN.1 fully resists to sotrovimab (S309) but maybe not to the upcoming AZD3152 (Omi-42) monoclonal Image
Read 9 tweets
Daniele Focosi, MD PhD MSc Profile picture
Dec 30, 2023
‼️🚨#IDTwitter : Dec 30 UPDATE (last of 2023🍾) of the tour of #SARSCoV2 loads the world #wastewaters , showing impact of #Pirola descendant JN.1 🧵

@EricTopol @SolidEvidence @LongDesertTrain @trvrb @jbloom_lab @ACasadevall1 @kakape @ewencallaway @angie_rasmussen @TRyanGregory
#SARSCoV2 in #wastewaters of
#Slovakia 🇸🇰 and #Hungary 🇭🇺 show increases, while #Austria 🇦🇹 shows signs of decline after peaking Image
#SARSCoV2 in #wastewaters of #Slovenija 🇸🇮 and #Germany 🇩🇪still skyrocketing , and no data from #Czech Republic 🇨🇿
@dokanders232 Image
Read 13 tweets
Daniele Focosi, MD PhD MSc Profile picture
Dec 13, 2023
‼️🚨#IDTwitter : Dec 13 UPDATE of the tour of the world wastewaters, showing impact of #Pirola descendant JN.1 🧵
@EricTopol @SolidEvidence @LongDesertTrain @trvrb @jbloom_lab @ACasadevall1 @yunlong_cao @sigallab @kakape @ewencallaway @JPWeiland
SARS-CoV-2 levels in #wastewaters of
#Austria (⬆️), #Slovakia and #Hungary Image
SARS-CoV-2 levels in #wastewaters of #Slovenia, #Germany (⬆️⬆️) and #Czechia
@dokanders232 Image
Read 15 tweets
Daniele Focosi, MD PhD MSc Profile picture
Dec 7, 2023
‼️🚨#IDTwitter : SARS-CoV-2 in wastewater analysis by country showing impact of #Pirola descendant JN.1 (much better than NPS) . A graph 🧵
@EricTopol @SolidEvidence @LongDesertTrain @SystemsVirology @trvrb @jbloom_lab @ACasadevall1 @yunlong_cao @kakape @ewencallaway @JPWeiland
Austria and The Netherlands are skyrocketing
@EllingUlrich @JosetteSchoenma @bjarijn @MarionKoopmans Image
Germany is also skyrocketing Image
Read 9 tweets
Daniele Focosi, MD PhD MSc Profile picture
Sep 7, 2023
With 4 great studies out so far in #Pirola and it’s 1st sublineage designated, it’s time to summarize findings, crosscheck predictions, solve discrepancies, & exhibit more tools. A🧵
@EricTopol @DrEricDing @TRyanGregory @ewencallaway @kakape @MarionKoopmans @florian_krammer
How fast is BA.2.86 spreading? (84 seqs so far). Variant seekers are reporting (@shay_fleishon, @LongDesertTrain, @OliasDave and @JosetteSchoenma paved the way), @RajlabN has a great time trend @HNimanFC has light-fast reporting and maps. @jampei2 has a Re model based on Denmark Image
How infectious is BA.2.86 for cells ? Data from @SystemsVirology and @yunlong_cao shows it’s not too bad in the current landscape Image
Read 11 tweets
Daniele Focosi, MD PhD MSc Profile picture
Sep 2, 2023
‼️SEP 3 UPDATE Spike convergent evolution in XBB.*
New FLip members: HK.8, HK.10, JJ.1.
HS.1.1 joins 456L+478R family
FL.1.5.1 recombined w/ “last of Cerberus” BQ.1.2.2
🧵
@RajlabN @LongDesertTrain @yunlong_cao @jbloom_lab @SystemsVirology @EricTopol @SolidEvidence @BarouchLab Image
This chart shows how common S:K478X acquisition has been so far in XBB* compared to former Omicron lineages… /2 Image
And the same is true for S:F456L, the propedeutic step to the S:L455F FLip first described by @yunlong_cao (see his preprint here: ) /3 biorxiv.org/content/10.110…
Image
Read 6 tweets

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