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Toni Choueiri, MD Profile picture
@DrChoueiri
Dec 24, 2023 • 11 tweets • 9 min read • Read on X
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It is this time of the year again: TOP 10 GU Oncology clinical papers/trials in 2023: Some negative, some positive, but we learned from all!

Feel free to add more & retweet & tag

This is not an exhaustive list!

@OncoAlert @danafarber @DanaFarber_GU

#OnwardFor2024 Image
1/#COSMIC-313 phase 3 trial shows ⬆️PFS with Cabozantinib plus Nivolumab and Ipilimumab in patients with previously untreated advanced or metastatic #RCC presented @myESMO #ESMO22

@motzermd @NEJM @tompowles1 @AlbigesL @DrDanielHeng @FabioSchutz78 @BurottoMauricio



COI: trial PInejm.org/doi/full/10.10…Image
2/In HRR-def #mCRPC: adding talazoparib to enza as 1L improved rPFS(HR=0.45), #PSA-progression, time to chemo, RR, could ⬆️OS (HR=0.69, immature) from Ph 3 #TALAPRO-2 trial. Presented #GU23 @ASCO

@neerajaiims @NatureMedicine #Fizazi @AzadOncology

nature.com/articles/s4159…


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3/ Addition of Nivolumab to Gem/Cis #chemotherapy as a 1L unresectable or #mUC significantly improves OS (HR=0.78) and PFS (HR=0.72). Presented #ESMO23 @myESMO

@MichvdHeijden @sonpavde @MattGalsky @NEJM @tompowles1

nejm.org/doi/full/10.10…

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4/Encouraging data from phase3 #THOR trial: in patients with refractory post-PD1 #mUC with #FGFR3/2 alt resulted in ⬆️OS and PFS with ⬇️ TRAEs compared to chemotherapy.

@y_loriot @NEJM @GustaveRoussy #Siefker-Radtke

nejm.org/doi/full/10.10…


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5/More therapeutic option for #nccRCC! Results from phase 2 trial #KEYNOTEB61 support the use of Pembro+Lenvatinib as 1L therapy for patents with previously untreated advanced #nccRCC

@AlbigesL @ChungHanLee3 @TheLancetOncol @myESMO

thelancet.com/journals/lanon…

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6/For patients with high-risk biochemical recurrent #PC: phase 3 #EMBARK shows that enzalutamide plus leuprolide and enzalutamide monotherapy were superior to leuprolide alone in term of metastasis-free survival!

@SFreedlandMD @nealshore @NEJM

nejm.org/doi/full/10.10…

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7/ Encouraging prelim findings from #AMG-509(xaluritamig): T cell engager targeting #STEAP1 immunotherapy in patients with #mCRPC improves clinical outcomes. Phase I safe and tolerable.

#kelly @LenAppleman @CD_AACR

aacrjournals.org/cancerdiscover…


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8/This phase 2 trial demonstrated that #NAC in high-grade #UTUC was tolerated, and lead to ⬆️PFS and OS of responders compared to non responders. Kudos to the exceptional team @MSKCancerCenter GU Center @DrRosenbergMSK

@JCO_ASCO @bbmdmsk #Coleman #Bajorin

ascopubs.org/doi/pdf/10.120…Image
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9/More on #RCC from#CONTACT-03 led by @montypal : 1st trial assessing #rechallenging with #ICI in #RCC with #anti-PDL1 didn’t show improvement of PFS and OS , w/ ⬆️toxicity.

@montypal @tompowles1 @TheLancet @ASCO @AlbigesL presented #ASCO23 @ASCO

thelancet.com/journals/lance…


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10/Promising data from this phase1 trial evaluating☢️ radioligand therapy with #ICI in patients with #mCRPC:a single priming dose of #LuPSMA followed by pembro maintenance was safe with confirmed OR.

@lawfong @thomashopemd @TheLancetOncol @myESMO

thelancet.com/journals/lanon…
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More from @DrChoueiri

Toni Choueiri, MD Profile picture
Jan 1
HIGHEST RANKED TRIALS for 2025

TOP 10 #cancerclinicaltrials in 2025 w/MOST Impact

1/ #DeLLphi304 @NEJM led by #Zeusofoncology @g_mountzios @HenryDunantGR : In relapsed SCLC post-platinum, BiTE DLL-3 Tarlatamab improved mOS vs. Chemo (13.6 vs 8.3 m, HR 0.60). PFS and in cancer-related dyspnea also improved.

nejm.org/doi/full/10.10…Image
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2/ Practice-changing trial, #ATOMIC in @JCO_ASCO: In dMMR stage III colon cancer, adding atezolizumab to adjuvant mFOLFOX6 improved DFS (HR 0.50!!)
@FASinicropeMD @DennisJHsu #JeffMeyerhardt -- #ASCO2025 Plenary discussed wonderfully by @MyriamChalabi @NKI_nl

ascopubs.org/doi/10.1200/JC…Image
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3/ #SERENA6 is the first Phase III trial to use a ctDNA-guided approach to tackle endocrine resistance: In ER+/HER2– metastatic breast cancer, early switch to Camizestrant upon ctDNA-detected ESR1 mutation markedly delayed progression. PFS 16.0 vs 9.2 m (HR 0.44). QoL decline was delayed and toxicity remained low. Glad to see our own investigator-extraordinaire @elmayerm @DanaFarber 2nd author. Also #ASCO2025 Plenary

nejm.org/doi/full/10.10…Image
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Read 10 tweets
Toni Choueiri, MD Profile picture
Dec 24, 2025
IT IS THIS TIME OF THE YEAR AGAIN!

TOP 10 GU clinical trials in 2025!

1/ Practice-changing IMvigor011: In ctDNA+ MIBC post-cystectomy, adjuvant atezo improved DFS (HR 0.64) & OS (HR 0.59) vs placebo. ctDNA- pts spared therapy w/ 2-yr DFS ~88%.
@tompowles1 @DrYukselUrun @OncoBellmunt @NEJM #ESMO2025 Plenary @myESMO

nejm.org/doi/full/10.10…Image
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2/ Updated EV-302 (2.5-yr f/u). EV+pembro as 1L SOC in la/mUC. PFS 12.5 vs 6.3 mo (HR 0.48); OS 33.8 vs 15.9 mo (HR 0.51) vs chemo. Durable benefit with no new safety signals.
@tompowles1 @shilpaonc

annalsofoncology.org/article/S0923-…Image
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3/ POTOMAC (Phase III): adding 1 year of durvalumab to BCG induction + maintenance In BCG-naive high-risk NMIBC significantly improved DFS vs BCG alone. 32% risk reduction for recurrence or death (HR 0.68) at ~5-yr f/u. Manageable safety profile. Supports IO + BCG as a potential new standard in high-risk NMIBC.

@tompowles1 @TheLancet @nealshore @mdesantis234 @AstraZeneca
thelancet.com/journals/lance…Image
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Read 10 tweets
Toni Choueiri, MD Profile picture
Jan 1, 2025
END OF YEAR TOP ALL CANCER TRIALS in 2024!

JUST in on 1 JAN 2025:

Paper 1:

#neoadjuvant checkpoint inhibitor Phase 3 trial in melanoma! #NADINA trial shows ipi+nivo significantly improves EFS vs. adjuvant nivo alone (HR 0.32, p<0.0001). #ASCO24 plenary #Melanoma @ASCO @ProfCUBlankNKI

nejm.org/doi/full/10.10…Image
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Paper 2:

The #TRANSMET study shows liver transplantation + chemo improves 5-year survival (56.6%) vs chemo alone (12.6%) for unresectable colorectal liver metastases. A potential game-changer in colorectal liver metastases! @TheLancetOncol



@GelliMaximilia1 @CHBPaulBrousse @GustaveRoussythelancet.com/journals/lance…Image
Paper 3:

The #TOPGEAR trial in @NEJM reveals: Adding preoperative chemoradiotherapy to perioperative chemo in resectable gastric cancer doubled pathological complete responses (17% vs 8%) but did not boost overall survival.

A step forward in understanding optimal strategies for gastric cancer treatment!

nejm.org/doi/full/10.10…
@Sydney_Uni @PeterMacRadOnc @OncoAlertImage
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Read 11 tweets
Toni Choueiri, MD Profile picture
Dec 27, 2024
IT IS THIS TIME OF THE YEAR AGAIN!

TOP 10 GU Bladder/Kidney Cancer TRIALS FOR 2024

1/ Enfortumab Vedotin (EV) + Pembrolizumab new SOC for patients with metastatic #UC. Trial #EV302 displaced 30y Platinum-based combos
⏩ PFS benefit: 12.5 vs 6.3 mo (HR= 0.45)
⏩ OS benefit: 31.5 vs 16.1 mo (HR= 0.47)

@tompowles1 @NEJM #ESMO2023 Plenary

nejm.org/doi/full/10.10…Image
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2/NIAGARA trial: Perioperative durvalumab with NAC in operable bladder cancer à EFS and OS benefit.
⏩32% reduction in risk of recurrence/death
⏩ 25% reduction in the risk of death
⏩No new safety signals.
🎯Potential new SOC for cisplatin-eligible MIBC!

#ESMO2024 Plenary

@tompowles1 again @NEJM

nejm.org/doi/full/10.10…Image
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3/ Keynote-564: 1st phase 3 trial to demonstrate overall survival benefit for adjuvant treatment in #RCC #Pembrolizumab

⏩38% reduced risk of recurrence/death (HR 0.62)
⏩New SOC for high-risk RCC post-nephrectomy

@NEJM with @ASCO GU 2024 Image
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Read 10 tweets
Toni Choueiri, MD Profile picture
Dec 26, 2023
And now, onto the Top 10 Translational GU Papers of 20-23. Again, not an exhaustive list, with some our @DanaFarber @DanaFarber_GU being involved in.

Let us start! Image
1/#RCC histological subtypes display diverse epigenetic configurations. Allelic imbalances play a role in modifying TF binding sites, especially through candidate SNPs.

Potential targets for future investigations and therapeutic strategies?

@AminNassarMD @sarahaboualaiwi @SylvanBacaLab #FreedmanLab

nature.com/articles/s4146…Image
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2/ Unlocking metastatic secrets: 🧬A novel #RCC model created with CRISPR-Cas9 editing reveals 9p21 disruption’s role, recurrent patterns driving progression, and #INF signaling’s

@perelli_luigi @LabGenovese @NatureCancer
nature.com/articles/s4301…

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Read 11 tweets
Toni Choueiri, MD Profile picture
Dec 29, 2022
It is this time of the year again: TOP 10 GU Oncology clinical papers/trials in 2022:

Some negative, some positive, but we learned from all!

Feel free to add more & retweet & tag anyone involved

This is not an exhaustive list!

@OncoAlert @DanaFarber

#OnwardFor2023 Image
1/ #ARASENS phase 3 trial shows ⬆️OS with darolutamide in combination with docetaxel and ADT in #mHSPC (vs docetaxel + ADT alone) with similar AE profile, leading to @US_FDA approval.
#MatthewSmith @BertrandTOMBAL @MGHMedicine @NEJM
nejm.org/doi/full/10.10… ImageImageImage
2/ In #PCa patients with detectable PSA after prostatectomy, lymph node RT + ADT+ PBRT⬆️freedom from progression compared to ADT+ PBRT and PBRT alone according to #SPPORT trial.
@_APollack @DrHowardSandler @TheLancet
thelancet.com/journals/lance… ImageImage
Read 11 tweets

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