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Toni Choueiri, MD Profile picture
@DrChoueiri
Dec 24 • 11 tweets • 9 min read • Read on X
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It is this time of the year again: TOP 10 GU Oncology clinical papers/trials in 2023: Some negative, some positive, but we learned from all!

Feel free to add more & retweet & tag

This is not an exhaustive list!

@OncoAlert @danafarber @DanaFarber_GU

#OnwardFor2024 Image
1/#COSMIC-313 phase 3 trial shows ⬆️PFS with Cabozantinib plus Nivolumab and Ipilimumab in patients with previously untreated advanced or metastatic #RCC presented @myESMO #ESMO22

@motzermd @NEJM @tompowles1 @AlbigesL @DrDanielHeng @FabioSchutz78 @BurottoMauricio



COI: trial PInejm.org/doi/full/10.10…Image
2/In HRR-def #mCRPC: adding talazoparib to enza as 1L improved rPFS(HR=0.45), #PSA-progression, time to chemo, RR, could ⬆️OS (HR=0.69, immature) from Ph 3 #TALAPRO-2 trial. Presented #GU23 @ASCO

@neerajaiims @NatureMedicine #Fizazi @AzadOncology

nature.com/articles/s4159…


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3/ Addition of Nivolumab to Gem/Cis #chemotherapy as a 1L unresectable or #mUC significantly improves OS (HR=0.78) and PFS (HR=0.72). Presented #ESMO23 @myESMO

@MichvdHeijden @sonpavde @MattGalsky @NEJM @tompowles1

nejm.org/doi/full/10.10…

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4/Encouraging data from phase3 #THOR trial: in patients with refractory post-PD1 #mUC with #FGFR3/2 alt resulted in ⬆️OS and PFS with ⬇️ TRAEs compared to chemotherapy.

@y_loriot @NEJM @GustaveRoussy #Siefker-Radtke

nejm.org/doi/full/10.10…


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5/More therapeutic option for #nccRCC! Results from phase 2 trial #KEYNOTEB61 support the use of Pembro+Lenvatinib as 1L therapy for patents with previously untreated advanced #nccRCC

@AlbigesL @ChungHanLee3 @TheLancetOncol @myESMO

thelancet.com/journals/lanon…

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6/For patients with high-risk biochemical recurrent #PC: phase 3 #EMBARK shows that enzalutamide plus leuprolide and enzalutamide monotherapy were superior to leuprolide alone in term of metastasis-free survival!

@SFreedlandMD @nealshore @NEJM

nejm.org/doi/full/10.10…

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7/ Encouraging prelim findings from #AMG-509(xaluritamig): T cell engager targeting #STEAP1 immunotherapy in patients with #mCRPC improves clinical outcomes. Phase I safe and tolerable.

#kelly @LenAppleman @CD_AACR

aacrjournals.org/cancerdiscover…


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8/This phase 2 trial demonstrated that #NAC in high-grade #UTUC was tolerated, and lead to ⬆️PFS and OS of responders compared to non responders. Kudos to the exceptional team @MSKCancerCenter GU Center @DrRosenbergMSK

@JCO_ASCO @bbmdmsk #Coleman #Bajorin

ascopubs.org/doi/pdf/10.120…Image
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9/More on #RCC from#CONTACT-03 led by @montypal : 1st trial assessing #rechallenging with #ICI in #RCC with #anti-PDL1 didn’t show improvement of PFS and OS , w/ ⬆️toxicity.

@montypal @tompowles1 @TheLancet @ASCO @AlbigesL presented #ASCO23 @ASCO

thelancet.com/journals/lance…


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10/Promising data from this phase1 trial evaluating☢️ radioligand therapy with #ICI in patients with #mCRPC:a single priming dose of #LuPSMA followed by pembro maintenance was safe with confirmed OR.

@lawfong @thomashopemd @TheLancetOncol @myESMO

thelancet.com/journals/lanon…
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More from @DrChoueiri

Toni Choueiri, MD Profile picture
Dec 29, 2022
It is this time of the year again: TOP 10 GU Oncology clinical papers/trials in 2022:

Some negative, some positive, but we learned from all!

Feel free to add more & retweet & tag anyone involved

This is not an exhaustive list!

@OncoAlert @DanaFarber

#OnwardFor2023 Image
1/ #ARASENS phase 3 trial shows ⬆️OS with darolutamide in combination with docetaxel and ADT in #mHSPC (vs docetaxel + ADT alone) with similar AE profile, leading to @US_FDA approval.
#MatthewSmith @BertrandTOMBAL @MGHMedicine @NEJM
nejm.org/doi/full/10.10… ImageImageImage
2/ In #PCa patients with detectable PSA after prostatectomy, lymph node RT + ADT+ PBRT⬆️freedom from progression compared to ADT+ PBRT and PBRT alone according to #SPPORT trial.
@_APollack @DrHowardSandler @TheLancet
thelancet.com/journals/lance… ImageImage
Read 11 tweets
Toni Choueiri, MD Profile picture
May 27, 2022
Now that #ASCO22 abstracts are released, more insights into Top 10 #GUOnc abstracts (still many LBAs):

@DanaFarber_GU @OncoAlert @ASCO @ASCOPost

1/LBA| Chris Ryan @OHSUKnight=>The long awaited EVEREST study with adjuvant everolimus in RCC: stay tuned!
2/Interesting relationship between DepOR and clinical outcomes in CM-9ER! Greater proportions of pts receiving Nivo+Cabo had deeper responses vs SUN. This translated into better PFS/OS

Dr. Cristina Súarez @vallhebron Image
3/Better HEQOL baseline scores were associated with significantly reduced death on Checkmate-214. Pts with improved/stable 6mo-HRQoL had a 52% reduction in risk of death compared to pts who had worsened.
@CellaDavid @MSSatNU Image
Read 10 tweets
Toni Choueiri, MD Profile picture
Dec 28, 2021
It is this time of the year again: TOP 20 GU Oncology clinical trials published in 2021:

Some negative, some positive, some led to @FDAOncology approval; we learned from all!

Feel free to add & retweet & tag anyone involved

This is not an exhaustive list

@OncoAlert
1/ (177Lu)–PSMA-617 showing improved PFS and OS in pre-treated mCRPC patients vs. SOC, in addition to a favorable safety profile @sartor_oliver @morr316 @NEJM
nejm.org/doi/full/10.10…
2/ MRI with targeted & standard biopsy in men with MRI suggestive of prostate cancer (PC) was noninferior to standard biopsy for detecting clinically significant PC &resulted in less detection of clinically insignificant cancer @NEJM @TobiasNordstrom
nejm.org/doi/full/10.10…
Read 22 tweets
Toni Choueiri, MD Profile picture
Aug 18, 2021
1/ On the heels of @ASCO #ASCO21 plenary, we are happy to share the results of KEYNOTE-564 trial of adjuvant pembrolizumab in mRCC just published in @NEJM ! A step towards better outcomes for all our patients with kidney cancer!
nejm.org/doi/full/10.10…
@OncoAlert @tompowles1
2/ Following nephrectomy for kidney cancer, a significant percentage of patients will experience disease recurrence, most of them with distant metastases, highlighting the need for effective adjuvant therapies.
3/ Despite many decades of research and clinical investigations, there are currently no globally approved adjuvant regimens for the management of #kidneycancer
Read 16 tweets
Toni Choueiri, MD Profile picture
Apr 22, 2021
Just out @NatureMedicine: Inhibition of HIF-2 alpha in RCC with belzutfian (MK-6482) - phase 1 trial and biomarker analysis- 1st study to report on the 2nd gen. HIF-2 inhibitors in pts with metastatic ccRCC!! @OncoAlert

A THREAD!

nature.com/articles/s4159…
1/The HIF2 axis biology is fascinating culminating in a 2019 @nobel prize, including our own @DanaFarber @kaelin_lab
2/In this study: 95 patients were enrolled (dose-escalation cohort: n=43 and dose-expansion cohort: n=52). Among these, 55 had advanced ccRCC, with a median age of 62 years, a median of 3 previous systemic therapies, and 76% (n=42) with intermediate/poor @IMDConline risk groups.
Read 16 tweets
Toni Choueiri, MD Profile picture
Jun 22, 2020
Proud of this @NatureMedicine collaboration with #FeedmanLab on a novel method detecting early stage RCC in plasma&urine w/cell-free DNA methylomes. Work led by super stars @PierVitaleNuzzo @Jberchuck @keegankorthauer #SandorSpisak
1/ RCC kills 175,000 patients worldwide with no screening test available acsjournals.onlinelibrary.wiley.com/doi/full/10.33….
A screening test that detects RCC while still localized (2/3 RCCs) will possibly reduce mortality. RCC and CNS tumors do not shed much cfDNA in the blood!
2/ Developed initially by @decarvalho_lab (co-senior author), we validated this ultra-sensitive cfMeDIP-seq using plasma cfDNA and, for the 1st time, cfDNA from urine samples collected in our #GelbCenter (Chair M. Pomerantz)
Read 13 tweets

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