Thread by @_HeartofGrace_

1/🚨🚨CLNICAL TRIALS ARE IN PROCESS ON THE HARMS OF EXOGENOUS DNA ON CHILDREN!

"Exploration of the Activity of DNA Located Outside of Cellular Nucleus to Amplify Inflammation in Inflammatory Bowel Disease in Children Through Biological Pathway Cyclic GMP-AMP Synthase (cGAS)

2/Exploration of the Activity of DNA Located Outside of Cellular Nucleus to Amplify Inflammation in Inflammatory Bowel Disease in Children Through Biological Pathway Cyclic GMP-AMP Synthase (cGAS) - Stimulator of Interferon Genes (STING) (ROXANE)

3/ ID NCT05916274

Sponsor Centre Hospitalier Régional d'Orléans
Information provided by Centre Hospitalier Régional d'Orléans (Responsible Party)
Last Update Posted 2023-06-23ClinicalTrials.gov
clinicaltrials.gov/study/NCT05916…

4/ "Study Overview
Brief Summary
Frequency of Inflammatory Bowel Diseases in children (IBD)-Crohn's disease (CD), Ulcerative colitis (UC) is constantly increasing. Pediatric-onset IBD represent a different nosological entity (from adult IBD) because of their

5/ major inflammatory activity, their significant anatomical extent and their stenotic and/or fistulizing character sometimes from diagnosis. Intestinal lesions are due to dysregulation of the intestinal immune system but the cause is unknown.

6/The investigators hypothesize that extranuclear DNA participates in the amplification of the inflammatory response at the intestinal and blood levels during pediatric IBD through the cGAS-STING pathway.

7/ The investigators will analyse blood and fecal samples, and colonic biopsies issued from ill children and control participants on age of 6 to 17 years. The investigators think that this study will provide a better understanding of the mechanisms involved in pediatric IBD,

8/ assess the place of the cGAS-STING pathway, identify potential biomarkers of pediatric IBD and new potential therapeutic targets based in particular on the inhibition of the cGAS-STING pathway.

9/ Extracellular and extranuclear DNA (enDNA) play a major role in innate immunity by stimulating pro-inflammatory responses and activating type I interferon production. The pro-inflammatory action of enDNA is mediated by enzyme cGAS,

10/ protein STING, toll-like receptor 9 (TLR9), and the inflammasome complex NLRP3. The investigators hypothesize that enDNA participates in the amplification of the inflammatory response at the intestinal and blood levels during pediatric IBD through the cGAS-STING pathway.

11/ They also hypothesize that there are links between the cGAS-STING pathway and other pathways involved in pediatric IBD such as NOD2 and Autophagy. The investigators will analyse blood and fecal samples,

12/ and colonic biopsies issued from ill children and controls on age of 6 to 17 years. The investigators think that this study will provide a better understanding of the mechanisms involved in pediatric IBD, assess the place of the cGAS-STING pathway,

13/ identify potential biomarkers of pediatric IBD and new potential therapeutic targets based in particular on the inhibition of the cGAS-STING pathway."
clinicaltrials.gov/study/NCT05916…

14/ (above is directly from the study--below is commentary)

The DNA plasmid contamination that has been recently discovered in the RNA vaccines is ds DNA, that is double stranded DNA. It is also exogenous. Exogenous means from outside.

15/ The DNA plasmids that were used in process TWO of what is currently, and what has been given, to over half of the Earth's population, were not filtered out properly. An old rule regarding DNA is in place that does not account for the use of an LNP--a transfection agent.

16/ Transfection is the process of artificially introducing nucleic acids (DNA or RNA) into cells.
thermofisher.com/us/en/home/ref…

17/ the ds (double stranded) DNA plasmid contamination has the same type of structure of what is being studied in this clinical trial.

18/ These clinical trials (there are more) have unbelievable potential for implications regarding human exposure to exogenous DNA via contamination in vaccines.

archive.is/8sXsq