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Prognostic Chats Profile picture
@PrognosticChats
Dec 28, 2023 • 32 tweets • 11 min read • Read on X
Here are the studies🧵Covid can cause;
Cognitive impairment, brain shrinkage, heart attacks, strokes, kidney damage, lung damage, diabetes, clots & other blood disorders, immunological & neurological disorders.
It is multisystem, acute & potentially chronic (1 in 10 infections)🧵
Covid infection can cause cognitive impairment & reduction in brain size.
Study: “A greater reduction in global brain size in the Covid positive cases. Those who were infected with Covid also showed on average a greater cognitive decline”
nature.com/articles/s4158…
Cognitive decline (memory impairment and reduced executive function) in those who had Covid.
The Lancet Healthy Longevity;
thelancet.com/journals/lanhl…
Covid can lead to heart attacks & strokes. Risk remains elevated for one year after an infection. Study: nature.com/articles/s4416…
Covid & Kidney damage
Study: “People with long-term COVID experienced substantial decline in eGFR (kidney function) within one year from the infection date”
academic.oup.com/ndt/article-ab…
Covid reinfection multisystem risks study: “Those people who were reinfected with Covid had:
X3.5 risk lung & kidney damage
X3 risk heart & blood disorders
X2 risk mental health disorders & new diabetes
X1.6 risk neurological disorders”
nature.com/articles/s4159…
reinfection also contributed to additional risks of;

death (risk x2.17)
and
hospitalisation (x3.32)
nature.com/articles/s4159…
Covid was the 3rd leading cause of death in Australia last year. Sadly Covid deaths continue. Despite undercounting from reduced surveillance & testing, it is still a leading cause of death globally.
bmj.com/content/381/bm…
You can get Long Covid/ Post-Covid Syndrome after your 1st, 2nd, 3rd, 4th, 5th infections. Every time you are infected you run the risk of post Covid Syndrome with a variety of potential complications.
🧵 on Long Covid / Post-Covid Syndrome
Covid causes impairment in mitochondrial function & skeletal muscle function with immune cell & amyloid deposits leading to severe exercise induced myopathy in LC
nature.com/articles/s4146…
Covid can interfere with your heart rate control, leading to palpitations, fainting, chest pain & a host of other symptoms, all through autonomic nervous system dysregulation. See BMJ Paper: Orthostatic tachycardia after covid-19
bmj.com/content/380/bm…
Covid causes 50% increased risk of New Onset Dementia in those aged >60, evident at 12 months post infection
X18 times increased risk with severe Covid infection
X2 times as much Cognitive Impairment with any infection (compared to those with no infection) - paper in linked tweet
p53 is a tumour suppressor-it helps stop cancer.
Covid proven to suppress p53 for
🚨16 weeks after mild/moderate infection
🚨At least 24 weeks after severe infection
journalofinfection.com/article/S0163-…
Covid causes brain damage; impaired memory & cognition, with falling IQ with each infection. The damage done is still evident 1 year after the infection (maybe longer - we are finding out as we go along now).
Proven brain damage.
The study; nejm.org/doi/full/10.10…
Covid (live virus) has been found in bone (skull) at autopsy, “suggesting that live virus is present in tissues postmortem, including bone” - this is not; mild, a cold, insignificant.
wwwnc.cdc.gov/eid/article/30…
Children’s cardiac risks 💔 post-acute Covid, children & adolescents are at statistically significant increased risk of hypertension, ventricular arrhythmias, myocarditis, heart failure, cardiomyopathy, cardiac arrest, clots, chest pain, & palpitations
medrxiv.org/content/10.110…
Children’s cognitive impairment due to covid infections 🚨

“Clinicians should be aware of cognitive impairment post-infection and its co-occurring nature with poorer sleep, behavioural and mental health symptoms.” July 2024 pubmed.ncbi.nlm.nih.gov/38735404/Image
More evidence on Covid leading to Diabetes here in The Lancet (Aug 2024)
thelancet.com/journals/landi…Image
Covid during pregnancy 🤰
- higher risk of severe illness
- higher risk of ICU
- x2 risk of still birth
- x2 risk of premature delivery
- higher risk of emergency caesarean
- higher risk of preeclampsia
rcog.org.uk/guidance/coron…Image
Covid can damage your liver: “Liver injuries have been documented in patients affected by COVID & commonly have mild increasing liver enzymes range from 14%-53%. Those with severe disease (hospitalised) have shown a higher increase in transaminase enzymes”
ncbi.nlm.nih.gov/pmc/articles/P…
Covid causes vascular inflammation in your brain & brain covering (meninges) that’s persists long after the acute infection. It’s not “mild”.
“new-onset AF (Atrial Fibrillation) represents a frequent complication in COVID-19
pmc.ncbi.nlm.nih.gov/articles/PMC98…
This study shows you have an elevated risk of heart attacks, strokes & death for 3 years after a Covid infection. This longterm risk increase from an infection is unique to Covid.

What happens with multiple infections? I think you know.

Study: ahajournals.org/doi/10.1161/AT…
2025 Study shows Covid causes PERSISTENT brain damage:
“These findings indicate that even mild COVID can result in persistent neurocognitive deficits, structural brain alterations & functional abnormalities, both in individuals with & without brain fog”
sciencedirect.com/science/articl…
We have known for some time that Covid causes brain damage. This Dec 2024 study adds to the info showing brainstem damage, you can’t function properly with a broken brainstem, ask most people with LC what happens to their heart rate when they stand up. academic.oup.com/brain/article/…
Covid is proven to cause damage to your blood vessels right down to the smallest ones (your capillaries). That’s why it has potential to harm every organ (as they all have blood supplies & are dependent on them).
Study from April 2025 rmdopen.bmj.com/content/11/2/e…
Covid causes vascular inflammation and microclots, a process minimised as “Covid toes” is actually clots & vascular
damage in your smallest blood vessels
Covid can damage your pancreas giving you insulin dependent diabetes
It can also damage your thyroid, making you dependent on medication for life (to live)
I know heart attacks, strokes, sudden death, dementia, cognitive impairment, autonomic failure (heart rate/breathing/gut issues), Parkinson’s, diabetes, thyroid failure, clots, autoimmune conditions, kidney, liver & lung damage didn’t get your attention…

So how about this?
More evidence on how Covid can damage your kidneys, cause chronic kidney issues & how those with kidney disease face a greater risk of severe illness & death with Covid infections…
More evidence on Covid causing “significant volume reductions” of your brain matter including cerebellum & brain stem, causing autonomic dysfunction, impaired motion & proprioception & disturbance of sleep cycles
medrxiv.org/content/10.110…

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More from @PrognosticChats

Prognostic Chats Profile picture
Sep 1
Lateral Flows

If it’s +ve you have Covid

If it’s -ve you might still have Covid as it’s got a high false negative rate & for many it may not turn +ve until days into an infection

So why test?
Because a positive confirms a Covid infection
A negative is less useful obviously 🧵
This is described as low test sensitivity (so it may not always turn positive straight away when infected), but a reasonable test specificity (you don’t get many false positives, ie if it’s positive then it’s Covid).

If you did 3 tests and got 1 +ve and 2 -ve you have Covid
Due to the false negative risk, it’s recommended to retest on serial days after exposure or if you have symptoms especially.

They are useful tools, but imprecise & due to false negatives can be falsely reassuring if you aren’t aware of this.
Read 4 tweets
Prognostic Chats Profile picture
Jun 27
“In the current era of high population immunity to COVID-19, additional COVID-19 doses provide very limited, if any, protection against infection and any subsequent onward transmission of infection.”
@DHSCgovuk June 2025

WHO is in charge??? Because this is completely wrong
“In line with JCVI advice, frontline health & social care workers (HSCWs) & staff working in care homes for older adults will not be eligible for COVID-19 vaccination under the national programme for autumn 2025” @DHSCgovuk
@theRCN @TheBMA
what are you going to do about this?
@DHSCgovuk @theRCN @TheBMA “This is following an extensive review by JCVI of the scientific evidence surrounding the impact of vaccination on transmission of the virus from HSCWs to patients, protection of HSCWs against symptoms of the disease & staff sickness absences”

…We have staff off with Covid now
Read 9 tweets
Prognostic Chats Profile picture
Jun 25
It’s 2025 so you all know
- Covid is airborne
- It lingers in the air for hours & that means you will breath in the virus after the infectious person has gone
- 1 way masking isn’t as good as 2way masking
- opening a window helps but doesn’t just fix it
- you can get it outdoors
- if you are sharing the air with an infectious person you are at risk, this includes within households & outdoors (airborne, not roomborne)
- duration of exposure generally matters
- mitigations are all layers that will help, some more so, no single one is the entire answer
- a positive test means stay away
- a negative test doesn’t necessarily mean you don’t have it (false negatives are well recognised)
- testing therefore has a positive predictive value, but a lower negative predictive value
- test may not turn positive until well into infection
Read 7 tweets
Prognostic Chats Profile picture
May 29
The “reality” now may be that people are trying to live life as if Covid doesn’t exist or is of no real significance
BUT the problem is that isn’t reality. Covid does exist & it’s still killing & disabling people in large numbers.
This is a crucial point 🧵
The “reality” of society adopting mass denial does nothing to mitigate the continued impacts of Covid infections.
Just because people do something, it doesn’t mean it’s right. Very often what people do is the easiest thing & it’s often wrong…
There is a huge difference between the “reality” of social behaviour & the reality of what is actually going on that requires an entirely different social behavioural response.

In this case that would be shifting social behaviour to actually respond to realty. To live with Covid
Read 5 tweets
Prognostic Chats Profile picture
May 26
Most doctors I know don’t realise the UK government stopped counting & reporting Covid deaths ages ago (zero community data), that they’ve never recorded long Covid numbers & they’ve no idea of the impact of reduced testing ie confirmation bias that numbers must be lower now…
They also have no idea what excess deaths are, the fact they’ve been high throughout the whole pandemic so far, or how ONS have shifted their baseline for this year so excess deaths now include the Covid associated deaths, again offering confirmation bias that everything is ok
This allows most doctors who want to live in denial to more easily do so, as we never get any figures on acute deaths, true admission numbers, numbers testing positive, or chronic impacts like long Covid or excess all cause mortality. Easier to pretend it isn’t happening.
Read 6 tweets
Prognostic Chats Profile picture
May 7
"During draft guidance consultation, consultees highlighted the treatment gap for children. At the second evaluation committee meeting one clinical expert explained that COVID‑19 rarely makes children unwell" NICE Covid Guidance 2025

How can an “expert” say this???
Study; Children’s cardiac risks from Covid💔

‘children & adolescents are at statistically SIGNIFICANT increased risk of hypertension, ventricular arrhythmias, myocarditis, heart failure, cardiomyopathy, cardiac arrest, clots, chest pain, & palpitations’

medrxiv.org/content/10.110…
Study 2; Rates of LC for children;
“12%-16% of those infected with Omicron met the research definition of long COVID at 3 & 6 months after infection, with no evidence of difference between cases of 1st positive & reinfected”

pmc.ncbi.nlm.nih.gov/articles/PMC10…
Read 9 tweets

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