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David Lingenfelter, PhD Profile picture
@dlingenfelter
Jan 6 • 4 tweets • 2 min read • Read on X
SARS-CoV-2 causes more damage to your immune system than HIV.

Both viruses induced a reduction in B cells and CD4+ T cells, but SARS-CoV-2 infection caused a more severe reduction in total T cells, CD8+ T cells, and NK cells than HIV infection.
researchgate.net/publication/34…
Here are the details. Image
Here's what Bing Copilot said about the article. Image
Now why on EARTH would we let an infectious airborne pathogen like SARS-CoV-2 run loose like that?

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More from @dlingenfelter

David Lingenfelter, PhD Profile picture
Dec 28, 2023
SARS-CoV-2 spreads through the air like smoke.

In modern times, the idea of airborne transmission of disease faced decades of resistance. This article 👇describes the long and complex history of its (re)emergence.🧵
papers.ssrn.com/sol3/papers.cf…
Image
For most of human history, diseases were thought to be transmitted by bad air or miasmas, often over long distances. This theory was challenged by germ theory in the 19th century, which identified specific microorganisms as the cause of diseases.
In 1910, Charles Chapin proposed that most diseases were transmitted by contact infection, either by direct contact or by close proximity. He dismissed airborne transmission as a negligible factor and influenced the public health field for decades.
Read 20 tweets
David Lingenfelter, PhD Profile picture
Aug 23, 2023
The endothelium is part of your vascular system, and it plays an important role in maintaining your health. Here is a 🧵 about what the endothelium is, what it does, how SARS-CoV-2 harms it, and what that means for your health. (1/n) Image
What is the endothelium and what does it do?

"The endothelium is a thin layer of flat epithelial cells that lines the heart, serous cavities, lymph vessels, and blood vessels. Endothelial cells form the barrier between vessels and tissue." (2/n)
en.wikipedia.org/wiki/Endotheli…
What is endotheliitis?

"Endotheliitis is an immune response within the endothelium in blood vessels, in which they become inflamed. The condition can cause swelling of the surrounding tissue, and can cause irritation and pain." (3/n)
en.wikipedia.org/wiki/Endotheli…
Read 16 tweets
David Lingenfelter, PhD Profile picture
Aug 20, 2023
Lymphocytes are part of your immune system, and they play an important role in protecting your health. Here is a 🧵 of what lymphocytes are, what they do, how SARS-CoV-2 harms them, and what that means for your health. (1/n)
What lymphocytes are.

"A lymphocyte is a type of white blood cell (leukocyte) in the immune system of most vertebrates. The three major types of lymphocytes are T cells, B cells and natural killer (NK) cells."
en.wikipedia.org/wiki/Lymphocyte
What lymphocytes do.

-B cells make antibodies that help your body fight infections.
-T cells attack foreign cells, cancer cells, and cells infected with a virus.
-NK cells contain substances that can kill tumor cells or cells infected with a virus. (3/n)
urmc.rochester.edu/encyclopedia/c…
Read 14 tweets
David Lingenfelter, PhD Profile picture
Aug 17, 2023
Key process...

"The presence of microclotting, together w relatively high levels of six inflammatory molecules known to be key drivers of endothelial and clotting pathology, points to thrombotic endotheliitis as a key pathological process in Long COVID."
medrxiv.org/content/10.110…
"Here we demonstrate significantly increased concentrations of Von Willebrand Factor, platelet factor 4, serum amyloid A, alpha-2antiplasmin, E-selectin, and platelet endothelial cell adhesion molecule-1, in the soluble part of the blood." Image
Is thrombotic.

"It was noteworthy that the mean level of alpha-2antiplasmin exceeded the upper limit of the laboratory reference range in Long COVID patients, and the other 5 were significantly elevated in Long COVID patients as compared to the controls. This is alarming..." Image
Read 5 tweets
David Lingenfelter, PhD Profile picture
Aug 17, 2023
On SARS-CoV-2 and monocytes...

There are about 30 trillion human cells in the adult human body, depending on the sex, age and weight. The human cells have been categorized into about 300 cell types based on location and function within the body. (1/n)
en.wikipedia.org/wiki/List_of_d…
They get around...

Monocytes are a type of leukocyte. They compose ~5% of all leukocytes in the human body. They circulate in the bloodstream for 1-3 days and then migrate into tissues where they differentiate into macrophages and dendritic cells. (2/n)
en.wikipedia.org/wiki/Monocyte
The big problem is that these monocytes can also harbor SAR-CoV-2, and like the Trojan Horse of old, can carry its infectious particles around. (3/n)
https://t.co/j2yQc2BKJw
Image
Read 8 tweets
David Lingenfelter, PhD Profile picture
Dec 10, 2022
Covid savages your immune system. Here's just one way.

"Cell-cell communication analysis revealed a CD22-CD45 signaling between the Class-switched memory B cell and the Activated CD4+ T cells, in healthy but not in the COVID-19 positive or recovered."
frontiersin.org/articles/10.33…
"PTPRC (CD45) has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with the antigen receptor complex, or by activating various Src family kinases."
en.wikipedia.org/wiki/PTPRC
"CD22 is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases."
en.wikipedia.org/wiki/CD22
Read 6 tweets

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