Thread by @outbreakupdates

We’re not just battling SARS-CoV-2.

We’re up against a pathogen that can recalibrate and weaponize our physiological processes against us.

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SARS-CoV-2 doesn’t just infect.

It actively engineers a pro-thrombotic state, exploiting the body’s own systems to amplify its pathological impact.

2/mdpi.com/2075-1729/14/2…

The body’s coagulation system is like a complex network of waterways, where PROS1 acts as the dam’s gatekeeper.

It’s meticulously regulating the flow to prevent flooding (thrombosis).

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SARS-CoV-2 is like a brutal force unleashing a torrential downpour (PLpro enzyme) aimed directly at the dam.

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This relentless storm weakens the dam’s structure (the anticoagulant function of PROS1), causing the gates to falter and floodwaters (blood clots) to surge uncontrollably through the cardiovascular system.

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This attack is cunningly precise.

It’s aiming directly at the gatekeeper’s weaknesses—signaled by CD147 expression.

The vulnerabilities in the dam’s regulatory system.

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When these are overly exposed or sensitive, the dam is far more susceptible to the storm’s fury, leading to catastrophic failures in the system.

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SARS-CoV-2 cleverly hijacks our body’s systems.

It’s articularly targeting PROS1, a crucial player in preventing blood clots.

By deploying its PLpro enzyme, the virus cuts through PROS1 directly at the infection site, tipping the balance toward dangerous clotting.

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This strategic manipulation not only worsens the infection but actively crafts a scenario ripe for clotting disasters.

It’s turning our own defenses against us.

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