The persistence of these autoantibodies and their potential to trigger a wide range of autoimmune disorders signal a looming public health challenge 🧵
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1/
SARS-CoV-2 infection precipitates the development of a broad spectrum of new-onset autoantibodies.
And they persist and remain elevated for at least a year post-infection.
2/medrxiv.org/content/10.110…
And they persist and remain elevated for at least a year post-infection.
2/medrxiv.org/content/10.110…
This means a profound and lasting dysregulation of the immune system, where the body’s defenses turn against its own tissues.
It will to a myriad of autoimmune conditions.
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It will to a myriad of autoimmune conditions.
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The association of these autoantibodies with neuropsychiatric symptoms show a direct link between immune dysregulation and long-term neurological sequelae.
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4/
The identification of molecular mimicry between the main epitopes of new-onset autoantibodies and the conserved fusion peptide of the spike is particularly concerning.
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5/
It means the immune response to the virus could mistakenly target similar sequences in the human body.
It’s leading to autoimmune reactions.
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It’s leading to autoimmune reactions.
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This mechanism could explain the persistent and diverse array of symptoms experienced by SARS-CoV-2 survivors.
It’s evidence of a deeper, more systemic disruption than previously understood.
7/7
It’s evidence of a deeper, more systemic disruption than previously understood.
7/7
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