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Feb 20 8 tweets 6 min read Read on X
In May 2021, despite having clear indications that the vaccines wouldn't halt transmission, persistent infections, Long COVID, or COVID's evolution, the CDC revised its guidelines to permit increased transmission. At that time, Walensky, the CDC director, declared, “Anyone who is fully vaccinated can participate in indoor and outdoor activities, large or small, without wearing a mask or physical distancing. If you are fully vaccinated, you can start doing the things that you had stopped doing because of the pandemic. We have all longed for this moment, when we can get back to some sense of normalcy.”

This misleading statement relieved the burden carried by conscientious individuals who prioritized protecting themselves and others. Its impact is still being felt, lingering in the minds of those who received the vaccine despite years of mounting data showing that immunity wanes and the reduced risk of infection is very short-lived (less than 3 months). We also have many studies showing the risks of asymptomatic or mild infections.


1/cnbc.com/2021/05/13/cdc…
(Published in Nature Medicine, May 17, 2021) "Modeling of the decay of the neutralization titer over the first 250 days after immunization predicts that a significant loss in protection from SARS-CoV-2 infection will occur, although protection from severe disease should be largely retained. Neutralization titers against some SARS-CoV-2 variants of concern are reduced compared with the vaccine strain, and our model predicts the relationship between neutralization and efficacy against viral variants."


2/nature.com/articles/s4159…
(August 11, 2021) "BNT162b2 effectiveness against any Delta infection, symptomatic or asymptomatic, was 64.2% ≥14 days after the first dose and before the second dose, but was only 53.5% ≥14 days after the second dose, in a population in which a large proportion of fully vaccinated persons received their second dose several months earlier."⬅️

"Both BNT162b2 and mRNA-1273 are highly effective in preventing Delta hospitalization and death, but less so in preventing infection, particularly for BNT162b2."

Pre-print published August 11, 2021
Published in Nature Medicine November 2, 2021:
3/medrxiv.org/content/10.110…
nature.com/articles/s4159…
(September 7, 2021) "Taken together, these data constitute an early signal for waning protection against symptomatic illness"

Did the CDC update the guidance based on a stream of new data showing waning immunity? No, they doubled down on more vaccinations. To this day, this is still the CDC's stance despite a mountain of evidence showing that the vaccines won't stop infections, #LongCOVID, or COVID's evolution. As a result, thousands are dying every week, and millions are suffering with Long COVID. Tens of millions of families are home with sick kids or out of work because they are sick themselves. This was predictable and this is preventable.

pre-print
published in PNAS nexus, June 8, 2022 - medrxiv.org/content/10.110…
academic.oup.com/pnasnexus/arti…
(Dec 9 2021) "Conclusions: These findings indicate that immunity against the delta variant of SARS-CoV-2 waned in all age groups a few months after receipt of the second dose of vaccine."

"The rate of confirmed SARS-CoV-2 infection showed a clear increase as a function of time from vaccination. Among persons 60 years of age or older who were fully vaccinated in the second half of January, the rate was 3.3 confirmed infections per 1000 persons during the study period, as compared with 2.2 confirmed infections per 1000 persons who became fully vaccinated in the second half of February and 1.7 confirmed infections per 1000 persons fully vaccinated in the second half of March. Similar results were observed in the other age groups and when the analysis was categorized according to age in decades."


5/nejm.org/doi/full/10.10…
(March 10, 2022) "Waning protection against infection over time was due to both declining immunity and the emergence of the delta variant."


(April 2022) "Vaccine effectiveness waned after the second dose: at 5 months"


6/nejm.org/doi/full/10.10…
thelancet.com/journals/lanin…
(October 21, 2022) "3rd dose monovalent efficacy against hospitalization decreased to just 29% after 120 days. That was against BA.5. It's going to be much lower against future variants.

What is already known about this topic?
"Monovalent mRNA vaccine effectiveness (VE) against COVID-19–associated hospitalization wanes over time; less is known about durability of protection during the SARS-CoV-2 Omicron BA.4/BA.5–predominant period."
What is added by this report?
"Three-dose monovalent mRNA VE estimates against COVID-19–associated hospitalization decreased with time since vaccination. Three-dose VE during the BA.1/BA.2 and BA.4/BA.5 periods was 79% and 60%, respectively, during the initial 120 days after the third dose and decreased to 41% and 29%, respectively, after 120 days from vaccination."


7/cdc.gov/mmwr/volumes/7…
The CDC is failing to provide guidance that prevents infections, persistent infections, and #LongCOVID. This isn't only killing and disabling millions of people. This is setting our children up for economic disaster and long-term health problems that lead to a diminished quality of life and ultimately shorter lives.

Is there evidence showing that COVID-19 can persist in children’s tonsils and adenoids even if they didn’t have any symptoms during the acute phase of the infection?

Yes. Tonsils and adenoids are major sites of persistent COVID-19 infections in children without any symptoms. The tonsils and adenoids are important for the development of the immune system.

We don’t know how many kids this is impacting or how many more it will impact. This study also suggests that persistent infections in the tonsils may play an important role in community transmission.

“Lymphoid tissue can be a reservoir of SARS-CoV-2 and may play an important role in community dissemination.”

sciencedirect.com/science/articl…

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More from @TactNowInfo

Feb 14
Just considering the removal of the 5-day isolation guidance shows a level of disregard for science that should trigger the firing or removal of the negligent people proposing it.

Every study shows that the vast majority of people remain infectious for at least 7 to 8 days, with many remaining infectious for 10 to 12 or more days. The peak infectious period is from 3 to 6 or 7 days. The guidance should have never been reduced from 10 days. 5 days is already anti-science and negligent. This potential guidance is absurd, and its implementation must be stopped.

Take notice of the people who support this. These people have no business being involved with public health. Their removal would serve all of society well.

reuters.com/world/us/us-cd…
The CDC has failed to protect public health and has been moving further away from following the science and data.  The guidance and reporting, which was already insufficient, has gotten much worse over the past 2 years. The Biden administration and the CDC must do their job and protect public health and safety. They must work to prevent disease instead of aiding in its spread by minimizing the risk and weakening the guidance.
Here are 10 things @JoeBiden/ @POTUS , the @CDCgov, and @CDCDirector have to do.

1.  We know that 3-7 days from the start of symptoms has been the peak infectious period. The CDC must change the 5 days isolation to 8 days,minimum. Preferably, 10 days like it was before. 

2. Many tests don't detect COVID during the first 2 to 3 days while people feel the worst.  Detecting COVID on the 4th or 5th day after people already took the test and got a negative result, causes people to believe it isn't COVID.  We have known this for at least 2 years. Why aren't the tests more accurate? (Note: the FDA should regularly test the efficacy of the tests and stop relying on manufacturers. The FDA and CDC should regularly update the results.)
Read 7 tweets
Feb 2
Evolution of COVID's Innate Immune Suppression and Evasion of Neutralizing Antibodies

A study published January 16, 2024 suggests that the virus's ability to evade our natural immune defenses, particularly the innate immune system, can continue to improve even after it has established itself in human populations. We have known that the herd immunity theory wasn’t true, but this is one more study showing us that the virus can continue to evolve to defeat our immune system. The direction the evolution is headed is very concerning. 1/
The researchers point out that SARS-CoV-2 has evolved a unique ability to infect various animal species, crossing species barriers. This highlights the virus's remarkable capability to overcome the specific immune responses of at least 34 different animal species. They point out that this adaptability is quite unusual and underscores the broader impact of the virus on various species. 2/
The study concluded saying, “We hypothesize an inevitable ongoing trajectory of adaptation towards escape from the innate immune mechanisms that are the gatekeepers of transmission success."(5)

A study on JN.1’s advantage over BA.2.86 was published by Eurosurveillance on January 11, 2024. It draws a similar conclusion regarding JN.1, pointing toward greater innate immune escape of JN.1 as opposed to greater neutralization escape.
3/
Read 5 tweets
Jan 22
A good reminder..
The mouth is a viral 'factory' with levels of the virus in saliva reaching 100 million per ml. That's half a billion in a 5 ml teaspoon.

"Viral dynamics of SARS-CoV-2 in saliva from infected patients"

"When compared to the respiratory tract samples, the sensitivity and specificity of saliva were 86.4% (95% CI 82.8%−89.4%) and 97.0% (95% CI 95.0%−98.3%), respectively."

ncbi.nlm.nih.gov/pmc/articles/P…
(March 2021) "SARS-CoV-2 infection of the oral cavity and saliva"

"These data show that the oral cavity is an important site for SARS-CoV-2 infection and implicate saliva as a potential route of SARS-CoV-2 transmission."

nature.com/articles/s4159…
"This result was recapitulated in vivo, where a 30-s oral rinse with cetylpyridinium chloride mouthwash eliminated live virus in the oral cavity of patients with coronavirus disease 19 for at least 1 h, whereas povidone-iodine and saline mouthwashes were ineffective."

pubmed.ncbi.nlm.nih.gov/35436499/Image
Image
Read 7 tweets
Dec 10, 2023
SARS-CoV-2 uses CD4 to infect T helper lymphocytes

Jul 31, 2023
COVID assembles viral factories, impairs cell function and may cause cell death. T helper cells express higher amounts of IL-10, which is associated with viral persistence & disease severity.
elifesciences.org/articles/84790
SARS-CoV-2 Dysregulates Neutrophil Degranulation and Reduces Lymphocyte Counts

"Infected neutrophils had a direct effect on peripheral blood lymphocyte counts, with decreasing numbers of CD19+ B cells, CD8+ T cells, and CD4+ T cells."

mdpi.com/2227-9059/10/2…
ACE2-independent infection of T lymphocytes by SARS-CoV-2"

"This work confirmed a SARS-CoV-2 infection of T cells, in a spike-ACE2-independent manner, which shed novel insights into the underlying mechanisms of SARS-CoV-2-induced lymphopenia in COVID."

nature.com/articles/s4139…
Read 8 tweets
Dec 1, 2023
🧵The Cause of the Mysterious Pneumonia Surging in China, South Korea, France, Netherlands, Denmark and the U.S. is Revealed

We uncover what's behind the surge in respiratory illnesses. How concerning is it?
1/
Bacterial pneumonia is often secondary to viral infections. Bacteria like that causing mycoplasma pneumonia are usually opportunistic, in that they take advantage of an immune system that has been weakened by a virus.
2/
So, for instance, influenza, RSV and the common cold can sometimes lead to bronchitis or pneumonia, infections of the upper and lower respiratory tract, respectively. We know that COVID can cause more damage to the immune system than the other viruses.
3/
Read 34 tweets
Oct 7, 2023
COVID's Life in 5 Steps
Step 1: Locate and infect a host.

Step 2: Suppress the immune response so the host doesn't know it's invading, weakening it for several weeks to many months and possibly for life.
Step 3: Infect areas of the body that the immune system can't reach, such as the pancreas, joints, brain, and central nervous system, and then relax in its new home.
Step 4: Adapt to new treatments by mutating. It leaves the door open by keeping the immune system depleted. If lucky, it meets a new variant.
Read 10 tweets

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