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Daniel Park Profile picture
@Daniel_E_Park
Feb 26, 2024 • 4 tweets • 3 min read • Read on X
Just released: Pretty remarkable 1-year durability data for Novavax 2-dose primary series. Though there is some expected waning, there was >65% efficacy at 1y (mRNA options typically wane to this level by ~4-5 months). Also fewer waning differences by age.
sciencedirect.com/science/articl…
Image
Refs:
NVX:
BNT:
Waning:
sciencedirect.com/science/articl…
sciencedirect.com/science/articl…
thelancet.com/journals/lanre…
To illustrate age stratified data, I took NVX data from the Japan paper and compared w/ a BNT paper from Norway. For BNT, nAbs & IgG largely back to baseline levels in older individuals by 5m, but remain at protective level at 1y w/ NVX, and more similar to young ages throughout. Image
Long-term durability is challenging to assess due to hybrid immunity, mutations, etc. More long-term durability studies are needed. But this adds to evidence from other observational data and animal models re: NVX durability

jamanetwork.com/journals/jaman…
nature.com/articles/s4146…

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More from @Daniel_E_Park

Daniel Park Profile picture
Apr 3
Preprint: Higher IgG4 is linked with lower neutralizing Ab & Fc receptor responses. Paper also suggests the Novavax platform may produce higher IgG1/3 and lower IgG4 compared with mRNA COVID vaccines. Image
To illustrate the magnitude:
NVX priming vs. mRNA priming = 49 vs 8,567 ng/mL in IgG4 (the bad one).
Conversely, IgG1 - 3 (the good ones) were similar or higher in the NVX group.

Link: medrxiv.org/content/10.110…
NVX also appears to have beneficial characteristics for protecting against newer variants due to:
1. less immune imprinting
2. enhanced Fc effector functions (that are less impacted by variant changes)
Read 6 tweets
Daniel Park Profile picture
Feb 23
New RCT comparing Moderna bivalent and Novavax (original strain) as a fourth dose. Novavax has:
- lower side effects
- similar cell mediated immunity, lower IgG response
- potentially broader protection vs variants Image
Link to study:

Side effects are a leading cause of vaccine hesitancy. The Novavax reactogenicity shows roughly half the frequency of each symptom, and lower severity. journalofinfection.com/article/S0163-…Image
The IgG responses are lower with the novavax vaccine, as consistent with prior studies. The authors note that these differences may not be meaningful as other RCTs and studies show similar efficacy with these differences in IgG levels. Image
Read 6 tweets
Daniel Park Profile picture
Feb 16
Having worked with many EIS officers, I can confirm they are among the best and brightest. They leave high-paying jobs to serve communities, ready to face danger at a moment’s notice. Now, the entire class has been let go. These heroes won’t be there when we need them.
One particular memory of mine that highlights the character of an EIS officer. We were on call with an EIS grad while he was in the field. Heard screeching tires and the line went dead. Called his cell, and he picked up and said calmly, "Hi, it's [name]".
I said, "oh we were worried you were in a car accident".
He said, "yeah I was. Our car flipped over. Let me call you back, I need to help our driver and check on the other car".
Read 6 tweets
Daniel Park Profile picture
Feb 1
Results from PREVENT-19 Novavax pediatric RCT of >1,000 adolescents.
- Vaccine efficacy was 74% (original Wuhan vax vs Delta variant).
- Nearly all infections after vaccination were asymptomatic or very mild.
- Viral load lower in vaccinated, but not statistically significant Image
Notably, this study used twice-weekly swabs to detect asymptomatic infections. Not directly comparable, but Moderna had 39% efficacy vs. asymptomatic infections in adolescents. Ad.26 was lower at 29%.
nejm.org/doi/10.1056/NE…
nejm.org/doi/10.1056/NE… Image
BNT (Pfizer) had 87% efficacy w/ less freq sampling (weekly), but with an asymptomatic proportion (~38%) suggesting some asymptomatic infections were potentially missed.
Read 5 tweets
Daniel Park Profile picture
Jan 17
Recent RCT: Co-administering NVX (COVID) & PCV20 (Pneumococcal) vaccines is as effective as when given separately, with no extra side effects.
This is key, as both diseases are major killers, and PCV may also reduce severe COVID by reducing pneumococcal carriage (🧵on this below) Image
Link to paper: journalofinfection.com/article/S0163-…
SARS-CoV-2 & S. pneumo can increase severity together. Early in the pandemic, we used endemic hCoV data to explore risk factors for severe illness. We found high-density S. pneumo carriage increased the risk of severe disease w/ concurrent hCoV infection.
journals.lww.com/pidj/fulltext/…Image
Read 10 tweets
Daniel Park Profile picture
Dec 28, 2024
Nice coverage from Vox on some of the benefits of the Novavax COVID vaccine: similar effectiveness, fewer side effects, and potentially longer lasting protection. Image
Since concerns about the mRNA platform and side effects are leading causes of vaccine hesitancy, increasing awareness will increase uptake and have societal benefits.
Link to article: vox.com/even-better/39…
I've also found it effective to point out the novavax vaccine has similar side effects to routinely used vaccines that almost everyone has already received
Read 5 tweets

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