Siim Land Profile picture
Apr 18, 2024 7 tweets 3 min read Read on X
The man who defies aging

Chuando Tan is a 58-year-old man from Singapore who looks like he's in his 20s or 30s

Here's a breakdown of his diet, exercise, and other routines⬇️⬇️
Image
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Chuando was born in 1966

He's been a model for decades and also does photography

He recently became popular on social media due to his youthful appearance despite being 58 Image
First, he obviously looks older than he did in his 20s but you could still easily confuse him for someone in his 20s or 30s

Second, clearly good genetics

Third, while we can't exclude the possibility of some treatments, he looks normal imo but I'm not an expert on that
Chuando has been following a very healthy and fit lifestyle all his life

He exercises 3-5 times a week for about 90 minutes each. Mostly weights, swimming, speed walking.

Gear? Probably although he weighs only 175 pounds
It would mess up his baby face tho Image
What's his diet?

A higher protein traditional fitness diet

His breakfast is 4 whole eggs and 2 egg whites, avocado

Other foods: chicken, fish, rice, vegetables, water

No smoking, alcohol, coffee, or tea

Sometimes he indulges on ice cream Image
He says he doesn't have skincare nor does he take supplements

It's funny how he looks younger than everyone else putting in significantly more effort

He certainly has the genetic card playing for him, but he also has a pretty fit lifestyle Image
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More from @siimland

Mar 18
The craziest study ever - The Minnesota Starvation Experiment

32 young men were put on a 40% calorie-restricted diet for 6 months, while staying physically very active

They lost 25% of their body weight by the end of it

Here's what this study contributed to longevity research Image
The men were fed 1,800 calories a day and expended 3,000 calories on physical activity

Their diet consisted of 77% carbohydrates, primarily from potatoes, cabbage, macaroni, and whole wheat bread, and <0.8 g/kg/day of protein to mimic starvation conditions Image
Keys monitored their health and saw their resting heart rate dropping from 55 to 35 beats per minute

They also developed edema from all the water they drank to stave off hunger

And the whites of their eyes became white like porcelain due to shrinking blood vessels in the eye Image
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Mar 16
He was called Putin's "anti-aging doctor," and he discovered what many consider the most promising longevity peptide.

In the 70s, Dr. Vladimir Khavinson discovered EPITALON, and he claimed it could make humans live longer

However, if you investigate deeper, the story gets messier⬇️⬇️

Full video: Image
Epitalon is a synthetic tetrapeptide with the sequence Ala–Glu–Asp–Gly (AEDG).

It was derived from a larger peptide mixture called epithalamin, originally extracted from the pineal gland of cows.

The idea: isolate the active fragment and turn it into a cleaner, synthetic compound.Image
Epitalon and epithalamin were discovered in the 1970s by Soviet researchers Dr. Vladimir Khavinson and Dr. Vyacheslav Morozov, who worked at the St. Petersburg Institute of Bioregulation and Gerontology.

They were researching bioregulators for military and medicinal use - to support immune system function, especially after radiation exposure.

Khavinson was a director of the institute later in Russia.Image
Read 15 tweets
Mar 14
Dr. Michael Crawford is 95 years old and as sharp as ever

After 50 years of researching brain nutrition, his conclusion:

The human brain evolved because of DHA from the marine food web.

Here’s the story ⬇️⬇️ Image
In the late 1960s, Crawford analyzed the brain lipids of 32 mammalian species.

He found that the chemical composition of the brain was nearly identical across species.

What differed was brain size, not chemistry.

One molecule stood out: DHA (docosahexaenoic acid) — an omega-3 fatty acid highly concentrated in neurons.

PMID: 22544773Image
Brain size relative to body size shrinks as animals get larger. Especially in land animals.

Examples:
- Small mammals (squirrels): ~2–2.5% brain/body weight
- Medium mammals (lions): 0.3-0.4% of body weight
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This pattern is consistent across land mammals.

As body size increases → relative brain size decreases.

PMID: 15866152Image
Read 12 tweets
Feb 5
Did you know your calves hide a second heart?

The soleus muscle, located deep beneath the calf, is often called the "second heart" because it plays a crucial role in pumping blood back to your upper body - supporting circulation and heart health

A 2022 study also found that stimulating the soleus can have significant benefits on your glucose metabolism⬇️⬇️

youtu.be/wSJClvkCznYImage
Blood flow from the feet back up is difficult because it has to fight against gravity

The soleus muscle helps to return deoxygenated blood back to the heart and prevents it from pooling in the legs

That's one of the reasons why sitting or standing for too long can be harmful Image
The soleus pushup is an amazing exercise for "pumping the second heart."

It's basically a seated calf raise that you can do while sitting Image
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Jan 5
Taurine has become one of the most popular longevity supplements

It mostly started after a study from last year that found that taurine supplementation extended the lifespan of mice by up to 25%

Here's everything you need to know about taurine⬇️⬇️

Full video: Image
What about human clinical trials?

They find that taurine at a dose of 0.5-6 g/day improves blood pressure, metabolic syndrome, and inflammation

1. pubmed.ncbi.nlm.nih.gov/32871172/
2. nature.com/articles/s4138…
3. sciencedirect.com/science/articl…
4. nature.com/articles/s4143…
However, most of these studies are done on people who are already diabetic, obese, or have hypertension.

So, it’s not right to say that otherwise healthy and lean people would see any benefits in these parameters.
Read 6 tweets
Dec 18, 2025
Glycine + NAC (GlyNAC) shows promise for healthy aging:
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PMID: 35975308

More: Image
A 2023 randomized clinical trial found that supplementing GlyNAC for 16 weeks in older adults improved glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, physical function, and 7 hallmarks of aging (PMID: 35975308)

The authors claimed: "Only GlyNAC supplementation in older adults resulted in significantly improved (a) glutathione concentrations by 121% after 2 weeks, and by 164% after 16 weeks to levels not different from younger adults."
A 2021 clinical trial saw that 24 weeks of GlyNAC in older adults reduced oxidative stress, fixed glutathione deficiency and mitochondrial dysfunction, lowered inflammation and insulin resistance, and improved gait speed, cognition, and body composition

PMID: 33783984 Image
Read 9 tweets

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