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Alpha-Ketoglutarate (AKG) is a key metabolite in producing energy
AKG has been seen to extend lifespan and healthspan in mice (PMID: 32877690)
Here's what you need to know about AKG⬇️⬇️
AKG is involved in the metabolism, specifically the Krebs cycle that generates energy (PMID: 32877686)
AKG levels decline with age and AKG regulates certain hallmarks of aging, such as mitochondrial function, genomic stability, and stem cell pluripotency (PMID: 36934991)
A 2022 review on AKG stated that there are a few studies suggesting AKG helps wound healing and recovery from surgeries, but there are no clinical trials showing the role of AKG in aging and age-related diseases as of now (PMID: 34952764)
Glutathione is called the body's master antioxidant:
- protects against oxidative stress
- has anti-inflammatory effects
- supports liver detoxification
Deficient glutathione underlies the oxidative stress in aging
Here's how to make enough glutathione⬇️⬇️
PMID: 34439468
Glutathione is made of primarily glutamine, cysteine, and glycine, which are amino acids
Glutathione synthesis is rate-limited by glycine (PMID: 29559876)
Taking N-acetylcysteine (NAC) and glycine has been shown to increase glutathione levels (PMID: 17602868; PMID: 21795440)
A 2023 randomized clinical trial found that supplementing glycine + NAC (GlyNAC) for 16 weeks in older adults improved glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, physical function, and 7 hallmarks of aging (PMID: 35975308)
Sauna use is one of the oldest biohacks that can promote your longevity:
- 63% lower risk of sudden cardiac death
- 63% reduced heart disease mortality
- 46% lower risk of hypertension
- 40% reduced all-cause mortality
And much more (THREAD)
Sauna use has many preventive effects on cardiovascular disease, hypertension, diabetes, neurodegeneration, and other chronic diseases (Patrick et al 2021)
Sauna mimics a lot of the benefits of exercise through hyperthermia and heat shock proteins
Saunas are basically sweat lodges or small rooms that are heated up to high temperatures.
The high temperature starts heating up your body, causing mild hyperthermia. Hyperthermia has benefits on immune and cardiac function (PMID: 3132509)