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Apr 18, 2024 7 tweets 3 min read Read on X
The man who defies aging

Chuando Tan is a 58-year-old man from Singapore who looks like he's in his 20s or 30s

Here's a breakdown of his diet, exercise, and other routines⬇️⬇️
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Chuando was born in 1966

He's been a model for decades and also does photography

He recently became popular on social media due to his youthful appearance despite being 58 Image
First, he obviously looks older than he did in his 20s but you could still easily confuse him for someone in his 20s or 30s

Second, clearly good genetics

Third, while we can't exclude the possibility of some treatments, he looks normal imo but I'm not an expert on that
Chuando has been following a very healthy and fit lifestyle all his life

He exercises 3-5 times a week for about 90 minutes each. Mostly weights, swimming, speed walking.

Gear? Probably although he weighs only 175 pounds
It would mess up his baby face tho Image
What's his diet?

A higher protein traditional fitness diet

His breakfast is 4 whole eggs and 2 egg whites, avocado

Other foods: chicken, fish, rice, vegetables, water

No smoking, alcohol, coffee, or tea

Sometimes he indulges on ice cream Image
He says he doesn't have skincare nor does he take supplements

It's funny how he looks younger than everyone else putting in significantly more effort

He certainly has the genetic card playing for him, but he also has a pretty fit lifestyle Image
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More from @siimland

Jul 30
NAD is considered a longevity molecule

Low levels of NAD accelerate the hallmarks of aging

But most people go about raising NAD levels the wrong way

Here's a thread about how to maximize your natural NAD production and minimize its loss⬇️⬇️ Image
First, what is NAD

NAD or Nicotinamide Adenine Dinucleotide is a co-enzyme that’s found in all living cells

You need NAD for:
- energy production
- metabolic processes
- mitochondrial function
- antioxidant defense
- DNA repair
- circadian rhythm

PMID: 26118927 Image
With age, you tend to see a decrease in NAD levels, although this isn't universal across tissues and individuals (PMID: 22848760)

Low NAD increases hallmarks of aging, such as cell senescence, DNA damage, and mitochondrial dysfunction (doi: 10.1016/j.tma.2018.08.003) Image
Read 15 tweets
Jul 26
Chromium is the mineral you didn't know you need more of:

- lower blood sugar and Hba1c
- lower cholesterol
- better insulin sensitivity
- better body composition

Deficient chromium can promote insulin resistance and dyslipidemia

Here's how to get your chromium (THREAD⬇️⬇️) Image
In 1959, a novel protein was discovered in Brewer’s yeast that was termed ‘glucose tolerance factor’ (GTF)

GTF's main component was identified to be trivalent chromium

GTF enhances insulin action, thus lowering blood sugar. Chromium is needed for insulin to bind to the cell Image
1. In diabetic patients, chromium-enriched yeast can decrease fasting blood glucose and insulin (PMID: 16632892).

2. In the 70s, chromium deficiency was seen to impair glucose tolerance, elevate triglycerides, prevent the use of glucose as energy, and cause neuropathy in patients with normal insulin levels on long-term total parental nutrition (PMID: 192066).

3. In a 2021 study, 400 mcg of chromium picolinate a day for 3 months improved glycemic control, reduced triglycerides, HOMA-IR, inflammation, and insulin levels (PMID: 33045675).

4. Taking 600 mcg of chromium picolinate a day for 4 months has shown a beneficial effect on the glycemic control of Type 2 diabetics (PMID: 26302914).

5. Chromium supplementation does not appear to improve insulin sensitivity in healthy non-obese people because they're already insulin sensitive. But it will certainly help individuals with poor glycemic control (PMID: 10819315)Image
Read 9 tweets
Jul 23
Glutathione is called the body's master antioxidant:
- protects against oxidative stress
- has anti-inflammatory effects
- supports liver detoxification

Deficient glutathione underlies the oxidative stress in aging

Here's how to make enough glutathione⬇️⬇️

PMID: 34439468 Image
Glutathione is made of primarily glutamine, cysteine, and glycine, which are amino acids

Glutathione synthesis is rate-limited by glycine (PMID: 29559876)

Taking N-acetylcysteine (NAC) and glycine has been shown to increase glutathione levels (PMID: 17602868; PMID: 21795440) Image
A 2023 randomized clinical trial found that supplementing glycine + NAC (GlyNAC) for 16 weeks in older adults improved glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, physical function, and 7 hallmarks of aging (PMID: 35975308) Image
Read 22 tweets
Jul 18
Low magnesium status drives all the hallmarks of aging:
- telomere shortening
- chronic inflammation
- stem cell exhaustion
- altered intracellular communication
- cellular senescence
- mitochondrial dysfunction
- dysregulated nutrient sensing
- disabled autophagy
- loss of proteostasis
- epigenetic changes
- gut dysbiosis

Thread⬇️⬇️

Graph: PMID: 38398820Image
Magnesium is the master mineral that's needed for countless essential processes in the body

- energy (ATP) production
- DNA repair
- neurotransmitters
- glucose regulation
- electrolyte balance
- heart function
- endothelial function
- blood pressure

And much more⬇️⬇️ Image
Magnesium deficiency leads to intracellular sodium and calcium accumulation

This promotes arterial vasospasms, blood vessel constriction, hypertension, and hypercoagulability

Coronary vasospasms are thought to be one of the causes of sudden cardiac death Image
Read 12 tweets
Jun 9
Dr. Valter Longo is a biogerontologist who created the fasting-mimicking diet (FMD).

In studies, the fasting-mimicking diet has been shown to:
- Lower PhenoAge biological age score by 2.5 years in 3 months
- Regenerate parts of the immune system
- Reduce insulin resistance
- Lower liver fat
- Reduce IGF-1 signaling
- Improve cardiometabolic health

Here's what you need to know 🧵

Video breakdown: youtu.be/TlWhwcPVkbQImage
Image
In a 2024 Nature Communications study, researchers analyzed data from randomized controlled trials of the fasting-mimicking diet.

After just 3 monthly cycles, participants saw a 2.5 year reduction in their PhenoAge score (PMID: 38378685). This result was independent of weight loss.

PhenoAge is a validated biological age score based on 9 blood biomarkers and chronological age.

Researchers then calculated biological age using PhenoAge. It has been shown to strongly predict mortality (PMID: 29676998).Image
Image
The participants of the FMD also saw improvements in risk factors for cardiovascular disease:

- systolic blood pressure
- waist circumference
- body fat
- IGF-1, which at high levels is associated with cancer risk Image
Read 12 tweets
Jun 6
NASA paid people $19,000 to lie in bed for 70 days straight.

No standing, walking, or even going to the bathroom allowed.

What they found was shocking in regard to what happens when the body stops moving🧵🧵 Image
Image
This was NASA’s 70-Day Bed Rest Study.

37 healthy adults were placed in strict 6° head-down tilt bed rest to mimic some effects of spaceflight.

Subjects had to remain tilted head-down for 70 days.

They could roll side to side but couldn’t stand, walk, sit upright, or even raise their head normally.

The goal was to study what happens when the human body stops fighting gravity.

Findings published: PMID: 29570535Image
NASA monitored them 24/7 and measured almost everything:
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- Muscle size
- Muscle strength
- Bone density
- Heart structure
- Plasma volume
- Glucose tolerance
- Insulin sensitivity
- Balance
- Reflexes
- Vision
- Brain MRI
- Immune markers
- Mood
- Cortisol

The results were quite shocking and rapid.
Read 13 tweets

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