Glycine + NAC (GlyNAC) shows promise for healthy aging:
- increased antioxidant defense
- reduced inflammation
- improved cardiometabolic risk factors
- improved physical function in the elderly
- reduction in hallmarks of aging
PMID: 35975308
More:
A 2023 randomized clinical trial found that supplementing GlyNAC for 16 weeks in older adults improved glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, physical function, and 7 hallmarks of aging (PMID: 35975308)
The authors claimed: "Only GlyNAC supplementation in older adults resulted in significantly improved (a) glutathione concentrations by 121% after 2 weeks, and by 164% after 16 weeks to levels not different from younger adults."
A 2021 clinical trial saw that 24 weeks of GlyNAC in older adults reduced oxidative stress, fixed glutathione deficiency and mitochondrial dysfunction, lowered inflammation and insulin resistance, and improved gait speed, cognition, and body composition
Exercise is known to be good for us, but how much exercise and is there something like too much exercise?
Exercise is often seen to have a J-shaped curve with mortality risk - not enough is bad but too much is also harmful (PMID: 26187713)
How much is optimal then?⬇️⬇️
The guidelines recommend adults get 150-300 min/week of moderate exercise or 75-150 min/week of vigorous exercise
Meeting that vs not is linked to a 36% lower odds of being overweight and 48% lower odds of being obese (PMID: 37773071)
However, exercising more than that is linked to a reduced risk of mortality
A 2022 study saw the lowest risk of mortality at 150-300 min/week of leisurely vigorous physical activity, 300-600 min/week of leisurely moderate physical activity, or a combination of both (PMID: 35876019)
Boron is the superhero mineral you're not getting enough of:
- helps bone mineralization
- improves vitamin D
- improves testosterone/estrogen status
- increases antioxidant defense
- reduces inflammation
- reduces calcium/magnesium loss
Boron is a trace element that is found in nature bound to oxygen and sodium
Boron is found in many foods, especially plants, as it's a structural component of plant cell walls, providing cell wall rigidity.
More than 90% of boron consumed is absorbed and distributed as boric acid
Boric acid forms ester complexes with many important sugars in energy production, such as ribose, and stabilizes them, helping to produce energy and combat fatigue (PMID: 24352855)