Dr Paddy Barrett Profile picture
May 17 14 tweets 4 min read Read on X
Jeanne Calment died in 1997 age 122.

She is thought to be the oldest living person on record.

What can we learn from healthy centenarians to extend our lifespan?

🧵👇

/1 Image
"All I Want To Know Is Where I'm Going To Die, So I'll Never Go There".

First off let’s see what most people die from.

That is, so we don’t go there.
/2 Image
In developed nations about 90% of people will die from an NCD. A non-communicable disease.

Think heart disease, cancer or dementia.

As opposed to a communicable disease such as malaria or an injury from a road traffic accident.
/3 Image
Most of us will die at some point after reaching 70 years of age.

Some in their 70s.

Some will have become centenarians.

But alarmingly, almost 25% of people will die age 50-69.

Very young.
/4
Regardless of age category, Charlie Mungers advice still applies.

The majority will die from cardiovascular disease, cancer or dementia.

But mostly cardiovascular disease.

The question then becomes:

How do we 'Not go there'?

/5
Over 90% of the risk of having a heart attack can be captured by 9 factors:

1. Smoking
2. Hypertension
3. Diabetes
4. Abdominal obesity
5. Excess Alcohol
6. Psychosocial Factors
7. Poor Nutrition
8. Inadequate Exercise
9. High Cholesterol


/6pubmed.ncbi.nlm.nih.gov/15364185/
We now know that most adults die from:

Cardiovascular disease, cancer or dementia.

But what do centenarians die from?

Sky Diving Accidents? Rock climbing injuries?

Nope!

Cardiovascular Disease, Cancer or Dementia.


/7cdc.gov/nchs/products/…
The key is...

They get these diseases about 20 to 25 years later than everyone else.

It's not that they live longer with the disease.

It’s that they live much longer without it.

They simply get chronic disease at a much later time point.
/8
A key reason why healthy centenarians get these conditions later in life is down to genetics.

But that doesn’t mean we cannot try & mimic this genetic advantage.

It also means we should be cautious in taking their recommendations on daily 'Apple cider vinegar' etc.
/9
So, if delaying the onset of a disease is the priority...

The focus then must be on the 'Risk Factors' for the disease.

Not the disease itself.

Remember those 9 'Risk Factors'?
/10
If by age 50 you hit these marks...

1. Never smoked.
2. Normal weight
3. Regularly Active
4. Drink modest alcohol
5. Good Nutrition.

You can potentially delay the onset of cardiovascular disease & cancer by 10 years.

This translates to added lifespan also.
/11 Image
None of this is a guarantee.

You can do everything right and bad things can still happen early in life.

It's all about putting the odds in your favour.
/12
But always remember Charlie Mungers words of wisdom:

"All I Want To Know Is Where I'm Going To Die So I'll Never Go There"

/13
That's a wrap!

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More from @Paddy_Barrett

May 19
Does Eating Red Meat Shorten Your Life?

The answer to this question is perfectly clear.

📕Make Sure To Bookmark✅

🧵👇

/1 Image
When attempting to answer this question

You need to consider 2 important variables:
1. Red Meat Consumption
2. How Long People Lived

Capturing consumption metrics is tricky.
Mortality is somewhat easier.

/2
But if you are assessing for mortality, i.e. whether someone is dead or alive

You usually need to do a study over a very long time.

And when it comes to nutrition studies that typically means using observational data

Not randomised data

/3
Read 14 tweets
May 18
Most people only think about cardiovascular risk late in life.

Here's why you should start thinking about it MUCH earlier than that.

🧵👇

/1 Image
The older you get, the greater your risk of having a heart attack.

No surprises there.

But let’s dig a little deeper.
/2 Image
Let’s look at things differently.

By the percentage of total events in each age category.

/3 Image
Read 22 tweets
May 10
Exercise is probably the single best way to extend lifespan.

You need to exercise like your life depends on it.

Because it does.

Here's why.

📕Make Sure To Bookmark✅

🧵👇
/1 Image
When someone says they ‘want to get fit’, I typically have no idea what they mean.

How you exercise if you want to be an Olympic-level sprinter compared to running 5 km at the weekends is vastly different.

So when you say you want to exercise to get fit, to what end?
/2
I base my goals on lifespan and health span:

to be an active and capable 90-year-old.

I want to win at the ‘game of life’.
/3
Read 22 tweets
May 8
Is alcohol good for you or bad for you?

Here's what the research says.

📕Make Sure To Bookmark✅

🧵👇

/1 Image
Let’s start with some simple facts.

Alcohol is a toxin.

Alcohol is a factor in:

30% of suicides
40% of fatal burn injuries
50% of fatal drownings
50% of homicides
65% of fatal falls
29% of fatal road traffic accidents.

/2
Globally, alcohol is responsible for 3 million deaths per year.

In the United States, it is the third leading cause of preventable death.

It is hard to see the upside when you see these figures.

So let’s go a little deeper.

/3
Read 24 tweets
May 6
Why Walking Might Save Your Life...

📕Make Sure To Bookmark✅

🧵👇

/1 Image
Walking.

Even for considerable distances.

Is something that most people can do.

And when they do it, the benefits are huge.

/2
Where did it all go wrong though?

Estimates vary, but the average adult will take about 5000 steps per day.

Some groups put this figure at between 3000 to 4000 steps per day.

This is concerning.

/3
Read 17 tweets
May 4
If you have a CT Calcium Score of 0

And have elevated LDL-C/APOB

Should you take cholesterol-lowering medications?

📕Make Sure To Bookmark✅

🧵👇

/1 Image
The origin of this debate lies in the predictive power of a Calcium Score (CAC) of 0.

With a CAC of 0

The risk of a major adverse cardiovascular event is low.

In many series <2% at 10 years.

Thats low.

In anyone's books.

/2 Image
So if your risk is so low

Why go on cholesterol-lowering treatment?

Good question.

Let's look at the difference in event rates in those with a CAC = 0

And whether they were on statin therapy or not.

Hard to see any difference there.

/3 Image
Read 13 tweets

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