ChatGPT not holding back... so many relevant things (which show the programming too 😏)
https://twitter.com/P_J_Buckhaults/status/1791895892985045199
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".. ChatGPT: In summary, introducing DNA into the lipid nanoparticles used for mRNA vaccines would complicate both the biological effects and the regulatory considerations of the vaccine."
".. ChatGPT: In summary, introducing DNA into the lipid nanoparticles used for mRNA vaccines would complicate both the biological effects and the regulatory considerations of the vaccine."
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".. ChatGPT: Incorporating plasmid DNA into lipid nanoparticles would significantly alter the vaccine's mechanism of action and its interaction with the immune system. Such changes would require extensive testing to ensure safety and effectiveness before any clinical use."
".. ChatGPT: Incorporating plasmid DNA into lipid nanoparticles would significantly alter the vaccine's mechanism of action and its interaction with the immune system. Such changes would require extensive testing to ensure safety and effectiveness before any clinical use."
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".. ChatGPT: In summary, small DNA fragments in an mRNA vaccine preparation could potentially activate the cGAS-STING pathway, contributing to both the immunogenicity and reactogenicity of the vaccine. This underscores the importance of rigorous purification processes in vaccine manufacturing to control for any such contaminants."
".. ChatGPT: In summary, small DNA fragments in an mRNA vaccine preparation could potentially activate the cGAS-STING pathway, contributing to both the immunogenicity and reactogenicity of the vaccine. This underscores the importance of rigorous purification processes in vaccine manufacturing to control for any such contaminants."
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This is sourly juicy, when taking account the proven biodistribution... 😬"Through preclinical testing should be done before any broader application" you say...?😶
".. ChatGPT: Given these potential outcomes, the tracking of lipid nanoparticles and the resultant immune activation within non-target tissues like the heart is a significant concern. It highlights the need for precise delivery technologies in the design of nanoparticle-based therapies and vaccines to minimize off-target effects and ensure safety. Additionally, thorough preclinical and clinical testing is essential to identify and mitigate such risks before broader application."
This is sourly juicy, when taking account the proven biodistribution... 😬"Through preclinical testing should be done before any broader application" you say...?😶
".. ChatGPT: Given these potential outcomes, the tracking of lipid nanoparticles and the resultant immune activation within non-target tissues like the heart is a significant concern. It highlights the need for precise delivery technologies in the design of nanoparticle-based therapies and vaccines to minimize off-target effects and ensure safety. Additionally, thorough preclinical and clinical testing is essential to identify and mitigate such risks before broader application."
@threadreaderapp pls unroll
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