Dr. Angela Rasmussen Profile picture
Jun 4 20 tweets 5 min read Read on X
People asking why this is factually incorrect…I’m at a conference today so am pressed for time but I’ll quickly address each of the 5 “key points.”

Bottom line: You can dress up unsupported horseshit in as much polished data viz as you want, but it still stinks.
Yes the virus emerged in Wuhan & the WIV is there & studies SARS-related CoVs, but that’s where the truth ends.

Shi Zhengli’s lab does great work on SARSr-CoVs, but they aren’t the only lab in the world doing so. They aren’t even the only lab in China doing this work. Image
In fact, people all over the world have been studying these viruses—including those isolated from bats—since SARS1 emerged in 2002. In the US, Australia, Hong Kong, Singapore, the UK, the Netherlands, Japan, France, Canada, and so on.
Fun fact: early in 2020 I joined a WHO Expert Group on experimentally modeling SARS-CoV-2. Multiple folks from China were there, none of whom were from WIV or Wuhan. SARS-CoV-1 emerged in China, so many labs there study these viruses. Wuhan isn’t special & WIV is one of many.
This is a little confusing, since the “defining feature” isn’t actually defined by the author. But she means the furin cleavage site.

She also neglects to mention this proposed work was not funded (thus likely didn’t occur) & all the FCS insertion work was to occur in the US. Image
And could this work have been done despite the multimillion dollar grant intended to support it? Sure. Is there evidence that this work was carried out anyway?

None whatsoever.

Most people don’t apply for DARPA grants they don’t need if they already have millions lying around
Yes the WIV did SARSr-CoV work at BSL-2 (consistent with the BMBL, the US’s standards for bat SARSr-CoVs).

No, this isn’t appropriate for SARS-CoV-2.

However, there is zero evidence that WIV had SARS-CoV-2 or a progenitor in their collection.

No SARS2 at WIV, no lab leak. Image
That’s pretty simple. It doesn’t matter what containment level the WIV was using for other SARSr-CoVs because those viruses are not SARS-CoV-2, nor could these viruses ever become SARS-CoV-2.

The viruses that WIV was known to have are more closely related to SARS-CoV-1.
Even the most closely related SARSr-CoV (RaTG13) in WIV’s collection is different by more than 1100 mutations across its entire genome. No amount of insertions, mutagenesis, or passaging in cells, transgenic mice, bats, or whatever else can make it SARS-CoV-2.
I’m closely related to my sibling and my parents. If I got cancer or HIV (which would cause mutations/insertions/recombination of my genome), it would not turn me into my brother or my parents.

Similarly, the WIV’s SARSr-CoVs can’t turn into SARS-CoV-2 at any containment level.
This is just plain incorrect. The hypothesis was published with enough supporting evidence to pass a rigorous peer review and be published in Science. The papers have not been retracted. Image
And just because a small but outspoken group of people—primarily those without any relevant professional or domain expertise, including the author of the NYT piece—claim these papers are disputed, debunked, or aren’t “strong” evidence doesn’t make those claims true.
If anyone can provide a legitimate analysis or plausible alternative explanation for these multiple threads of evidence, then they should submit it for peer review by experts and publish it in a scientific journal.

So far no such paper has been produced.
Here’s a summary of the Worobey et al 2022 paper.

Critics have had 2 years to challenge these results scientifically, providing additional evidence or a compelling alternative interpretation of these data. These papers & their findings have not been substantively challenged.
Finally, no shit “key evidence” is still missing. The role of the market in the pandemic’s emergence was covered up in ways that didn’t apply to SARS1 or MERS. The market was closed. Live animals were removed. Clearly evidence was suppressed, not collected, or not made accessible Image
However, that doesn’t mean the evidence we DO have doesn’t support market origin. Existing affirmative evidence isn’t invalidated by a lack of other types of evidence.

Again, I have yet to see an alternative explanation for the multiple threads of evidence supporting zoonosis.
“No infected animals at the market” (because samples weren’t taken to look for said infected animals) doesn’t disprove all the other evidence that very clearly points to the market.
Evidence isn’t a carton of milk. It doesn’t expire if you don’t find it. Intermediate hosts of SARS1 and MERS were not found in days as claimed and sometimes they are never found. It took years to find the reservoir for Marburg virus. Nobody debates that it is zoonotic.
Supposedly this was fact-checked by @nytimes—not well enough.

This matters. Watch this clip of Dr. Fauci talking about the sickening threats made against him & his family.

Factually incorrect claims like those in this piece encourage these threats.
cnn.com/2024/06/03/pol…
It is grossly irresponsible to say that these 5 unsupported claims mean the pandemic “probably” started with a lab leak. They misrepresent the actual evidence and put people like Dr. Fauci at great risk.

The @nytopinion has shamed itself by printing untruths & outright lies.

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Dr. Angela Rasmussen

Dr. Angela Rasmussen Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @angie_rasmussen

Aug 2
Yesterday I shared this piece by me & 40 colleagues on the harms of the “lab leak” hypothesis inflicts on science & scientists.

I’m not finished talking about it. The origins “debate” has consumed my life for >4 years & I want to talk personally about the damage it has caused.
First I’ll review what the commentary says because I know not everyone will read it. People are busy & @JVirology is not always going to publish thrilling page-turners for non-virologists. But here’s the link if you do want to read—it’s pretty accessible:

journals.asm.org/doi/10.1128/jv…
There are two hypotheses for how the pandemic began:

1. Lab leak: virologists made it and it came from a virology lab

2. Zoonosis: it was transmitted from an infected animal to a person at the Huanan market in Wuhan

Both are reasonable.

Only one is supported by evidence. Image
Read 28 tweets
Jul 31
There's a big problem with the way the US is responding to the H5N1 cattle outbreak.

Samples are not being tested in a timely manner (months later) and then these results are not being disclosed in a timely manner (again, months later) either.

This outbreak is not containable.
A central principle of outbreak response and containment is to identify cases so they can be isolated. From there, contact tracing and quarantine measures need to be applied with the goal of eliminating further onward transmission (to cows, as well as spillover to humans).
In order for this to work, cases need to be identified as quickly as possible to prevent further spread and more undetected cases, which can then go on to spread the virus to new cows/animals/people.

And to identify cases quickly, you need to test in a timely manner.
Read 7 tweets
Jun 16
In spring 2020, Craig described NY Presbyterian Hospital to me as “the fucking apocalypse.”

By July, the same sentient pancake stack bragging about his spaceships told me that even though an even bigger surge was hitting sunbelt states, the epi data was “bs” & PCR is fake.
Because I, a virologist with 2 masters & a PhD, ~20 yrs experience with emerging viruses, & whose life at the time was like the forced reeducation scene in Clockwork Orange except with COVID data, was less skillful at interpreting basic epi data than a rich dude with opinions.


Image
Image
Image
Image
This was a very stupid Twitter fight. It’s subjective who “won”—and certainly there were a lot of fanboys mad that I blasphemed their savior & ruined their fucking Mars colonization fantasies—but the consensus was that Elon was factually incorrect.
independent.co.uk/life-style/elo…
Read 10 tweets
May 23
This is great news, as more testing is urgently needed, but there are some caveats.

Wastewater data can be difficult to interpret. It can be especially difficult to identify the source and won’t catch anything not connected to municipal sewage systems (many farms are not).
Because there is no data indicating widespread human infection, spikes of H5 in wastewater could indicate dumping of infected milk, birds or other animals defecating into sewersheds, etc. Unlike other environmental samples, the host can be very difficult to identify.
Host sequences are completely disentangled in from viral sequences in wastewater, so there’s no way to figure out where a strong H5 signal is coming from with the WW sequences alone. If there’s an obvious source (affected dairy dumping tanks of milk) that might explain a spike.
Read 8 tweets
May 3
Out now on @virological_org: preliminary report on the genomic epidemiology of H5N1 sequences in cattle. This complements the preprint @USDA put out yesterday.

There was a lot of data to work with, so it's split in two parts 👇🏼

virological.org/t/preliminary-…
virological.org/t/preliminary-…
Some key findings from this preliminary analysis:

1. There was a reassortment event shortly before the cattle outbreak.

Only segmented viruses like influenza can reassort. If 2 viruses infect the same host, they can shuffle their genome segments like 2 decks of cards
1. Reassortant viruses can acquire new features, including the ability to replicate efficiently in new host species. In this case, some of the segments were from the high path Eurasian panzootic H5N1 genotypes & some from low path North American genotypes emerging in late 2023. Image
Read 22 tweets
Apr 24
Very important to note here that qPCR positives are not the same as "virus particles." It's much easier to detect viral RNA by qPCR than it is to detect infectious virus or intact virus particles (as the article correctly notes).

This finding does have some big implications:
1. This suggests there are undetected herds shedding virus into the milk supply. Viral RNA does not materialize out of thin air—it is the product of a current or very recent viral infection.

No virus replicating in cows, no viral RNA in milk.

No viral RNA, no PCR positives.
1+. qPCR detects virus by amplifying small specific fragments of the viral genome. There's no indication that they pulled entire H5N1 genome sequences out of this, which would likely require signaling. Influenza is segmented, however, so no word on which segments they amplified.
Read 20 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us!

:(