Dr. Angela Rasmussen Profile picture
Jun 4, 2024 20 tweets 5 min read Read on X
People asking why this is factually incorrect…I’m at a conference today so am pressed for time but I’ll quickly address each of the 5 “key points.”

Bottom line: You can dress up unsupported horseshit in as much polished data viz as you want, but it still stinks.
Yes the virus emerged in Wuhan & the WIV is there & studies SARS-related CoVs, but that’s where the truth ends.

Shi Zhengli’s lab does great work on SARSr-CoVs, but they aren’t the only lab in the world doing so. They aren’t even the only lab in China doing this work. Image
In fact, people all over the world have been studying these viruses—including those isolated from bats—since SARS1 emerged in 2002. In the US, Australia, Hong Kong, Singapore, the UK, the Netherlands, Japan, France, Canada, and so on.
Fun fact: early in 2020 I joined a WHO Expert Group on experimentally modeling SARS-CoV-2. Multiple folks from China were there, none of whom were from WIV or Wuhan. SARS-CoV-1 emerged in China, so many labs there study these viruses. Wuhan isn’t special & WIV is one of many.
This is a little confusing, since the “defining feature” isn’t actually defined by the author. But she means the furin cleavage site.

She also neglects to mention this proposed work was not funded (thus likely didn’t occur) & all the FCS insertion work was to occur in the US. Image
And could this work have been done despite the multimillion dollar grant intended to support it? Sure. Is there evidence that this work was carried out anyway?

None whatsoever.

Most people don’t apply for DARPA grants they don’t need if they already have millions lying around
Yes the WIV did SARSr-CoV work at BSL-2 (consistent with the BMBL, the US’s standards for bat SARSr-CoVs).

No, this isn’t appropriate for SARS-CoV-2.

However, there is zero evidence that WIV had SARS-CoV-2 or a progenitor in their collection.

No SARS2 at WIV, no lab leak. Image
That’s pretty simple. It doesn’t matter what containment level the WIV was using for other SARSr-CoVs because those viruses are not SARS-CoV-2, nor could these viruses ever become SARS-CoV-2.

The viruses that WIV was known to have are more closely related to SARS-CoV-1.
Even the most closely related SARSr-CoV (RaTG13) in WIV’s collection is different by more than 1100 mutations across its entire genome. No amount of insertions, mutagenesis, or passaging in cells, transgenic mice, bats, or whatever else can make it SARS-CoV-2.
I’m closely related to my sibling and my parents. If I got cancer or HIV (which would cause mutations/insertions/recombination of my genome), it would not turn me into my brother or my parents.

Similarly, the WIV’s SARSr-CoVs can’t turn into SARS-CoV-2 at any containment level.
This is just plain incorrect. The hypothesis was published with enough supporting evidence to pass a rigorous peer review and be published in Science. The papers have not been retracted. Image
And just because a small but outspoken group of people—primarily those without any relevant professional or domain expertise, including the author of the NYT piece—claim these papers are disputed, debunked, or aren’t “strong” evidence doesn’t make those claims true.
If anyone can provide a legitimate analysis or plausible alternative explanation for these multiple threads of evidence, then they should submit it for peer review by experts and publish it in a scientific journal.

So far no such paper has been produced.
Here’s a summary of the Worobey et al 2022 paper.

Critics have had 2 years to challenge these results scientifically, providing additional evidence or a compelling alternative interpretation of these data. These papers & their findings have not been substantively challenged.
Finally, no shit “key evidence” is still missing. The role of the market in the pandemic’s emergence was covered up in ways that didn’t apply to SARS1 or MERS. The market was closed. Live animals were removed. Clearly evidence was suppressed, not collected, or not made accessible Image
However, that doesn’t mean the evidence we DO have doesn’t support market origin. Existing affirmative evidence isn’t invalidated by a lack of other types of evidence.

Again, I have yet to see an alternative explanation for the multiple threads of evidence supporting zoonosis.
“No infected animals at the market” (because samples weren’t taken to look for said infected animals) doesn’t disprove all the other evidence that very clearly points to the market.
Evidence isn’t a carton of milk. It doesn’t expire if you don’t find it. Intermediate hosts of SARS1 and MERS were not found in days as claimed and sometimes they are never found. It took years to find the reservoir for Marburg virus. Nobody debates that it is zoonotic.
Supposedly this was fact-checked by @nytimes—not well enough.

This matters. Watch this clip of Dr. Fauci talking about the sickening threats made against him & his family.

Factually incorrect claims like those in this piece encourage these threats.
cnn.com/2024/06/03/pol…
It is grossly irresponsible to say that these 5 unsupported claims mean the pandemic “probably” started with a lab leak. They misrepresent the actual evidence and put people like Dr. Fauci at great risk.

The @nytopinion has shamed itself by printing untruths & outright lies.

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More from @angie_rasmussen

May 14
In case you you were wondering what’s going on in Canadian medical freedom/anti-vax news, the embarrassing off-brand J6ers of the True North convoyed out to BC to prevent 400 H5N1-infected ostriches from being culled.

This got me thinking about H5N1 in ostrich hosts 🧵👇🏻
When I came across this bright idea that these ostriches are somehow now H5N1 cure factories. I blame the movie Outbreak for giving people the idea that you can cure highly pathogenic viruses with serum or whatever. But H5N1 pathogenicity exists across a range of severity.
If ostriches don’t get very sick, it’s not obvious which ones are infected or not. And there aren’t a whole lot of ostrich challenge studies out there, but here’s one. They infected ostrich chicks with high path H5N1 & they didn’t get sick.

tandfonline.com/doi/abs/10.108…
Read 11 tweets
May 7
New EO banning “dangerous gain-of-function” experiments dropped Monday.

Allow me to break out my deranged anti-vax kakistocrat translator.

Will this improve the safety & security of biological research?

Hell yes, because biological research won’t exist anymore! Image
I do kind of love the idea that Trump’s path to dictatorship includes a proclamation on his political position on mouse adaptation, unregulated DNA synthesis, & whatever else is deemed subjectively dangerous by authors who obviously know fuck all about it.
whitehouse.gov/presidential-a…
This seems bad:

GOF lab leak
Biden allowed GOF free for all
NIH gave $$ to leak-prone foreign labs

Bold claims. Got any evidence to back them up?

Last I checked, GOF moratorium was lifted under Trump in 2017.

For the millionth time, evidence is consistent with zoonotic origin Image
Read 26 tweets
May 2
I am often challenged to provide an example of a vaccine that could not have been developed without doing gain-of-function virology research.

Thanks to HHS @SecKennedy and former @BiosafetyNow board member @DrJBhattacharya, I now have an answer:

Generation Gold Standard Image
Can't complain about half a billion for a "next-generation universal vaccine platform"! What is this amazingly innovative new vaccine technology? Tell me more, because this says "BPL-inactivated, whole virus platform". That describes current flu vaccines.
hhs.gov/press-room/hhs…
The press release did not offer more details so I looked at a paper about it. This was testing a quadrivalent BPL-inactivated vaccine (vaccine made of 4 inactivated low path avian viruses) by a heterosubtypic (different HxNy subtype) challenge.
pmc.ncbi.nlm.nih.gov/articles/PMC11…
Read 12 tweets
Apr 22
I am the co-Editor-in-Chief of @Els_Vaccine & I’ll be the first to say that a lot about academic publishing needs reform.

But replacing peer review with ideologically-driven censorship or shutting journals down in the name of “free speech” is not reform. Image
FYI to the NIH Director: having your paper rejected because peer reviewers found it lacked scientific merit is not censorship or gatekeeping. It means your work didn’t pass muster & wasn’t up to scientific standards. Expert peer review is what distinguishes a journal from a blog. Image
I can’t speak for CHEST but I assume their editorial viewpoint is similar to @Els_Vaccine’s: publish the best quality scientific work in the field (vaccines in Vaccine, chests in CHEST). If your paper is rejected, it’s because it wasn’t of sufficient quality or rigor, not POV.
Read 8 tweets
Apr 21
So this interview lasted 2 hours so this “you’re scaring me” part might seem like an overreaction or fearmongering to someone without that context.

There’s a lot of evidence to support my hypothesis that a potential H5N1 pandemic would be worse than COVID.
The clade 2.3.4.4.b viruses circulating in the US have infected many different mammalian species. In the course of this, we are seeing many opportunities for these viruses to adapt to mammalian hosts, including switching receptor usage & increasing virus fitness.
Viruses going back & forth in many mammalian hosts creates a lot of unique and complex selection pressures. It also leads to more infected individual animals, including in species we have frequent contact with: cows, poultry, dogs, cats, rodents, peridomestic wildlife.
Read 13 tweets
Apr 8
One thing I’ve been wondering about: why is H5N1 so quiet? It’s everywhere & exposure risk remains high.

No news on new cases. Is this because there are no new cases or just less testing? So I took a look at some numbers.

Spoiler: it’s bad policy & sabotaged response capacity.
Over at @CDCgov, they maintain an updated H5N1 situation report so I thought I’d see if that gave any indication of what’s going on.

cdc.gov/bird-flu/situa…
Take the National Flu Surveillance numbers. When President Trump was sworn in on Jan 20, 89K specimens were tested using an assay that can detect novel flu A viruses. To date this has identified 3 H5N1 cases. Image
Read 15 tweets

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