Lurking_Lethoceris Profile picture
Jun 5 102 tweets 9 min read Read on X
I am starting up my live coverage thread of the June 5th VRBPAC meeting.
It begins at 8:30am ET and can be watched here:
It has started.
They are doing the roll call for the committee members right now.
I like how all of the pediatric specialist were added to the committee after the push for pediatric vaccine access last year by advocates and activists (which is still ongoing as the pediatric novavax vaccine isn't available).
There are currently over 600 viewers on the stream for this event which is impressive.
Dr. Offit and Dr. Meissner being consultants for the FDA and the committee is interesting as they are pro-infection.
Dr. Jerry Weir introduction is now starting.
It is interesting that they are considering availability of vaccine candidates regarding the strain selection so they don't screw over the manufacturers.
The voting question is about a monovalent JN.1 lineage vaccine.
Dr. Meissner has mentioned the idea of different strain selection by vaccine type.
The CDC is up next
Dr. Thornburg is presenting now.
This is interesting as a surge is definitively starting. Image
I am mortified by type of this graph each time it is shown as it shows that infected a vast majority of the population with SARS-CoV-2. Image
This graph really need to be shown in conjunction with a phylogenic tree of some nature. Image
There is going to be an updated nowcast coming out this weekend.
The limited amount of sequences is due to lack of testing not the due to the amount of community transmission.
Okay, so KP.2-like and KP.3-like lineages are very similar to JN.1 as per Dr. Thornburg of the CDC.
Yeah, they are setting up rational for JN.1 as the selected strain right now.
This is a noteworthy slide Image
No difference between the severity of JN lineages and XBB lineages based on the P-values. Image
Dr. Link-Gelles is presenting on vaccine effectiveness now.
Once again it is jarring. Image
That potential negative efficiency in age 50 and up is concerning. Image
The previous graph is probably where they derived the four month interval for a new vaccine for (despite it being a bad idea due immune response issues).
Just wow. The vaccines wane way to quickly. Image
The error bars here are absurd. Image
Image
There is an efficiency issue after 120 days. Image
The error bars are a result of the low sample size and vaccine coverage as per the CDC. I personally think that the mRNA vaccines have a serious waning issue. Image
As per the CDC, 50% of the children who died from SARS-CoV-2 had no underlying conditions.
Okay, they are stating that the amount of people who all getting additional doses via being immunocompromised is pretty low, which makes sense with how pharmacies are making it a pain to do so.
The WHO is up next
Dr. Wentworth is presenting
The who is going to be making recommendations twice per year.
From the WHO: Image
More rational for a monovalent JN.1 vaccine Image
I like how the WHO is saying most of the changes are in the S1 and not the S2 part of the spike protein.
The WHO stated that it takes a month to make antiserum so there is a pretty noteworthy testing delay.
They will back in 10 minutes from their break.
The break is over.
Moderna is up next
Moderna's sample size of 49 is way too low.
The error bars in log graphs are such a pain to interpret.
As per Moderna Image
Moderna is good with either JN.1 or KP.2 as the strain.
Pfizer is up next
Someone such as the CDC should do something about this. Image
Image
This graph needs letters showing which values are significantly different. It is a pain to tell if one performs better. Image
Thank you Dr. Levy for mentioning the statistics issue with not showing significant difference or the lack of.
Novavax is up
Dr. Walker is the presenter
Image
N=59 from the previously posted graph is subpar.
I am not a fan of Novavax's presentation.
Dr. Jerry Weir is now presenting.
Lunch break is now
The public comment section is starting
First speaker is up
@we_are_ssd did a great public comment. I agree with a two doses of the 2024-2025 formulation be a good idea.
Doing some thread nonsense to avoid tagging people in every future post here.
The current speaker is discussing that the current amount doses per year, which is problematic.
Don Ford is up now
Great presentation by @DonEford
More thread magic and Dr. David Wiseman is up
Okay the frameshifting problem is a real thing
Mark Gibbons is next
Burton Eller is next
Burton raises some good points. We should honestly have all fire departments stock rabies vaccine and SARS-CoV-2 to help assist rural communities.
Sue Peschin is next
Sue Peschin made some solid points. Protein vaccine accessibility is great for equity when some of the population cannot get the mRNA vaccine.
Thair Phillips is next
Dr. Andrew Wang is next
The public comment section is over
Dr. Offit is wrong considering all of the vaccine waning data. Also, everyone getting the vaccine protects the vulnerable better.
Thank you CDC for pushing back against Dr. Offit's weird nonsense.
Novavax's representative could be a lot better.
Contrary to Dr. Meissner, hybrid immunity is not a thing with SARS-CoV-2.
Yes, the CDC's messaging on the risk of SARS-CoV-2 is really ineffective.
Manufacturer submitting time is going to influence the time of approval from the FDA as per Dr. Weir
Bivalent idea was instantly shutdown.
Vaccine effectiveness against long covid is really hard to test for as per the CDC.
Dr. Bernstein is suggesting that not all groups should have access to the vaccine, which is a bad idea.
The US and Canada are smart for having a universal recommendation for the seasonal flu and SARS-CoV-2 vaccine.
Another break is happening
The discussion about the voting question has begun
Voting has starting after a very short discussion.
They all voted yes.
The 2024-2025 vaccine is going to be a JN.1 lineage.
They are now discussing which JN.1 lineage to pick.
They are discussing the merits of JN.1 right now.
Some decent points are being discussed right now.
Dr. Marks is probably just confusing the committee right now with different strains based on the vaccine type.
Dr. Monto's statement about KP.2 and KP.3 being in opposite directions on the graphs is a solid rebuttal.
I agree that the safety data should be public for transparency.
Early vaccine access before the start of the school year would be clutch in hindering surges associated with schools.
Dr. Marks really doesn't like the importance of novavax compared to mRNA.
I agree with Dr. Nelsen that the immunocompromised definition should be expanded.
It seems like JN.1 was selected as the strain by the committee.
The meeting was adjourned.

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More from @LurkLethoceris

Feb 28
The ACIP meeting is now live for those who to watch it: I am going to be live tweeting about it here.video.ibm.com/channel/VWBXKB…
The effective concern leading to people not getting vaccinated is a concerning result. Novavax can probably be used to get those people on board as the three dose series is really effective. CDC slide from ACIP Feb 28 2024
This date is interesting. Image
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