Cognitive dissonance is hitting people hard with the most recent COVID surges.
They were sold a narrative of "just a cold", but the experiences they're having conflict with that spin.
First they notice that they're experiencing the worst "cold" they can remember... in the summer.
Then they start noticing persistent fatigue after they've supposedly recovered. And a chronic cough. And weird moments where they lose their train of thought mid-sentence. It's a disconcerting situation to be in.
Then they get infected again with digestive symptoms, despite having just had it fairly recently (again, in the summer).
Then they look around and notice everyone around them going through the same thing. They notice hospitals masking again. They notice that more coworkers are off sick all of a sudden.
Not everyone is connecting the dots to COVID just yet, but something still seems off, at least.
The common refrain right now is that there's a lot of illness going around. Some may instinctually call it a cold or the flu, but personal experiences are starting to diverge from the informal definitions assigned to those terms in the zeitgeist.
It's unfortunate that people have been so thoroughly coerced and lulled by authorities into suffering long-term consequences from repeated COVID infections. In a few months, the harsh reality of chronic illness and disability will dawn on large waves of people currently dealing with acute infections. For some, the term "long COVID" will enter their lexicon.
All we can do at this point is continue to inform those willing to listen. Prevention is not futile. Prevention is not synonymous with "lockdown", either. Long-term health outcomes still matter. And just like any other noxious substance, less exposure is better than more.
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We are clearly in the midst of an anomalously severe flu season.
Although H5N1 has not been detected in high numbers among humans, there's a good chance that it's quietly playing a significant role without even infecting humans directly.
How, exactly? Let's lay it all out: 🧵
If you want the answer up front without having to read through a detailed explanation, you can skip to the summary and conclusion in the last few posts of the thread.
Otherwise, read on!
To understand how influenza evolves, you need to trace the progression of the virus from its source.
All mammalian influenza A viruses are thought to originate in birds. They then find their way to certain mammals, where the viruses mutate significantly.
There's been a sharp increase in unsubtyped influenza A detected in Canada and beyond over the last few weeks.
Compared to the previous two seasons, influenza only passed the epidemic threshold (5% test positivity) in January compared to a October/November start.
What's up? 🧵
By definition, influenza A without a subtype remains unidentified.
However, given that influenza A shares a gene with H5N1, it is still possible that at least some of those positive results are in fact H5N1.
Amid the gloom and doom, I'm excited to share news that gives me hope.
Invivyd has announced positive initial findings from an ongoing clinical trial of a monoclonal antibody to be used as a pre-exposure prophylactic to prevent COVID-19 infections.
Here are the highlights: 🧵
Invivyd has been developing a monoclonal antibody to prevent COVID infection.
The idea is you'd get it once or twice a year and get better protection against COVID than available vaccines.
This could make it much easier to avoid long COVID, especially combined with respirators.
VYD2311 is a monoclonal antibody with neutralization ability against various lineages including XBB.1.5, and it reportedly achieves increased neutralization over pemivibart (pemgarda).
Note: JN.1 neutralization has been confirmed in vitro for pemivibart.