Guarding Your Liver: A Gentle Reminder for Long COVID Warriors Using Supplements
If you’re living with Long COVID, you’ve likely found yourself exploring all kinds of supplements and medications in search of relief. With lingering symptoms/damage like fatigue, brain issues, POTS, MCAS and heart issues, it’s natural to want to try anything that might help. But in this journey, there’s one thing you must not forget: your liver.
You see, COVID-19 itself can damage your liver. Many of the people I know who have Long COVID, are experiencing elevated liver enzymes, which is a sign that their livers are struggling. Add supplements or medications into the mix, and ones liver, already working hard to recover from the effects of the virus, could face even more stress.
Your Liver: A Quiet Guardian
The liver quietly takes care of so much for you. It’s responsible for processing everything that enters your body—medications, supplements, food, even toxins. It transforms these into substances your body can safely use or eliminate. When the liver gets overwhelmed, though, it can’t keep up. That’s when things start to go wrong. Early signs of liver trouble might be subtle or completely hidden, but over time, damage can become more serious.
This is why it’s so important to be mindful of what you put into your body, especially when managing Long COVID. Supplements and medications, while helpful in the right context, can sometimes add to the burden on your liver.
The Hidden Dangers of Supplements and Medications
Many people assume that supplements—especially “natural” ones—are always safe. But natural doesn’t always mean harmless. Certain herbs and extracts, like green tea extract, kava, and comfrey, have been linked to liver damage, particularly when taken in high doses or over a long period.
Even over-the-counter medications can carry risks. Acetaminophen (Tylenol), a common pain reliever, is known to cause liver damage if taken in excessive amounts. And it’s easy to accidentally go over the safe limit if you’re taking multiple products that contain it, especially without realizing it.
Prescription drugs can pose similar risks. Medications like statins, certain antibiotics, and antiviral drugs may affect liver function, particularly in people with ongoing health issues. For someone already dealing with the aftereffects of COVID-19, these medications might pose additional challenges for the liver.
How to Protect Your Liver While Navigating Long COVID
Your liver is already working overtime to help your body recover from the damage COVID-19 has caused. To give it the support it needs, here are a few steps you can take:
1. Do your research: Before starting any new supplement or medication, look into its potential effects on your liver. The more informed you are, the better you can protect yourself.
2. Consult your healthcare provider: If you’re taking multiple medications or supplements, it’s a good idea to check in with your doctor or pharmacist. They can help identify possible risks or interactions and might recommend regular liver function tests to catch any issues early on.
3. Stick to recommended doses: When it comes to supplements or medications, more is not always better. Following dosing guidelines can help ensure that you’re not putting unnecessary strain on your liver.
4. Know the warning signs: Fatigue, jaundice (yellowing of the skin or eyes), dark urine, or unexplained nausea can all be signs that your liver is in distress. If you notice any of these, seek medical advice right away.
Remember: COVID-19 and Supplements Can Both Stress Your Liver
Long COVID is hard enough without adding liver damage to the mix. As your body works to heal from the virus, your liver plays a critical role in managing the detoxification process. Be mindful of what you take—whether it’s a supplement, over-the-counter drug, or prescription medication—because your liver is already dealing with the effects of COVID-19 itself. By taking a few extra steps to protect your liver, you can ensure that your pursuit of healing doesn’t come at the cost of another vital part of your body.
The liver is a vital organ responsible for numerous essential functions, including detoxification, protein synthesis, and hormone production. While the liver has a remarkable ability to regenerate and detoxify itself, some people consider using supplements to support liver health. Below is a guide on the most common liver supplements and their potential benefits.
Common Liver Supplements
1. Milk Thistle (Silymarin)
- Benefits: Milk thistle is one of the most popular supplements for liver health. It contains silymarin, a compound with antioxidant and anti-inflammatory properties. It is believed to protect liver cells from toxins and aid in liver cell regeneration[1][2][6].
- Usage: Available in various forms such as capsules, tablets, and extracts. It is generally well-tolerated, but it may cause gastrointestinal issues or allergic reactions in some individuals[6].
2. Artichoke Leaf Extract
- Benefits: Artichoke leaf is thought to have antioxidant properties that may support liver health. It might also promote bile production, aiding in digestion and detoxification[2][4].
- Usage: Often found in combination with other liver-supporting herbs. Consultation with a healthcare provider is recommended before use[2].
3. Dandelion Root
- Benefits: Traditionally used as a liver tonic, dandelion root may help increase bile flow. However, scientific evidence supporting its efficacy is limited[2][4].
- Usage: Available as teas, capsules, or extracts. It is advisable to discuss with a healthcare provider before starting[2].
4. Turmeric (Curcumin)
- Benefits: Curcumin, the active ingredient in turmeric, has anti-inflammatory properties that may protect against liver injury[5].
- Usage: Can be consumed as a spice or in supplement form. It is important to ensure proper dosage and consult with a healthcare provider[5].
5. Zinc
- Benefits: Zinc is an essential trace element that supports immune function and may help protect the liver from oxidative stress, particularly in chronic liver diseases[3].
- Usage: Available in various supplement forms. It is important to adhere to recommended dosages to avoid toxicity[3].
Considerations and Precautions
- Consultation with Healthcare Providers: Before starting any liver supplement, it is crucial to consult with a healthcare provider, especially if you have existing health conditions or are taking medications. Some supplements can interact with medications or cause adverse effects[1][3][5].
- Lifestyle Modifications: Supplements should not replace healthy lifestyle choices. A balanced diet, regular exercise, limiting alcohol consumption, and avoiding high-fat and sugary foods are essential for maintaining liver health[1][5].
- Potential Risks: While some supplements may offer benefits, there is limited scientific evidence to fully support their efficacy. Some herbal supplements can even cause liver damage or interact negatively with other medications[3][5].
In conclusion, while liver supplements like milk thistle, artichoke leaf, and dandelion root are popular, their effectiveness varies, and they should be used with caution. Prioritizing a healthy lifestyle and consulting healthcare professionals are key steps in supporting liver health.
Is their evidence for viral persistence in COVID-19?
From the meticulous work of the PolyBio Research Foundation, in collaboration with the esteemed halls of UC San Francisco and Harvard Medical School, to the robust findings published in Nature and The Lancet, we are presented with compelling evidence of the virus’s tenacity.
These studies not only confirm the presence of viral proteins and RNA months after the acute phase of infection but also suggest a troubling link to the chronic, debilitating symptoms known as long COVID.
Let’s delve into some of the evidence for the evidence pointing to viral persistence of SARS-CoV-2,
1. PolyBio Research Foundation Study
A study published by the PolyBio Research Foundation, supported by UC San Francisco and Harvard Medical School, found that viral proteins from SARS-CoV-2 could persist in the body for up to 14 months post-infection. This study used an ultra-sensitive blood test to detect viral proteins in 25% of the 171 participants, indicating that the virus can linger in tissues and organs long after recovery from the acute phase of the infection. The likelihood of detecting these proteins was higher among those who were hospitalized or reported severe symptoms during their initial infection[1].
2. Nature Study on Persistent SARS-CoV-2 RNA Shedding
A cohort study published in *Nature* identified persistent SARS-CoV-2 RNA shedding in individuals for at least 30 days, with some cases extending to 60 days. The study found that individuals with persistent infections had more than 50% higher odds of reporting long COVID symptoms compared to those with non-persistent infections. This suggests that persistent infections could contribute to the pathophysiology of long COVID, although the exact mechanisms remain to be fully understood[3].
3. NCBI Study on Long COVID and Viral Persistence
Research published on NCBI proposed a hypothesis-driven model for long COVID, suggesting that the persistence of SARS-CoV-2 or its components (such as the spike protein) could lead to chronic inflammation and a dysregulated immune response. This model is supported by evidence of viral RNA and antigens being detected in various tissues, including the cerebrospinal fluid and feces, months after the initial infection. The study highlights the potential for viral persistence to trigger long-term health issues[2].
4. Lancet Study on Viral Persistence in Tissues
A study published in *The Lancet* examined the persistence of SARS-CoV-2 in various tissues, including blood, gastrointestinal, and surgical samples. The research found that viral RNA and proteins could be detected in these tissues long after the acute phase of infection, suggesting that the virus can persist in different parts of the body and potentially contribute to ongoing symptoms and health complications[5].
5. NCBI Study on Viral Persistence and Reactivation
Another study on NCBI explored the persistence of viral RNA and antigens in patients with long COVID. It found that viral components could be detected in blood, stool, and urine, and that the presence of these components was associated with persistent symptoms. The study also noted that viral persistence might involve either active replication or the presence of non-replicating viral RNA, which could still trigger immune responses and inflammation[4].
The evidence from these studies collectively supports the notion that SARS-CoV-2 can persist in the body for extended periods, potentially leading to long-term health issues such as long COVID. This persistence can involve both active viral replication and the presence of viral components that continue to stimulate the immune system, leading to chronic inflammation and other symptoms.
Further research should be done to put to rest this question of viral persistence and to develop effective treatments for long-term COVID.
A study reveals that SARS-CoV-2 can infect human CD4+ T helper cells, impacting the immune response in severe COVID-19 cases. The virus uses the CD4 molecule to enter these cells, leading to functional impairment and cell death. This infection results in increased IL-10 production in T cells, associated with viral persistence and severe disease. The findings suggest that SARS-CoV-2 infection of CD4+ T cells contributes to immune dysfunction in COVID-19.