"The use of antivirals to reduce the risk of long COVID is grounded in the hypothesis that viral persistence and possible ongoing replication of SARS-CoV-2 are major mechanistic pathways responsible for long COVID..
[Growing] Data from multiple settings have shown evidence of viral persistence (ie, persistence of viral RNA or protein fragments) for months or years in multiple organ systems including the gut, brain, kidneys, and blood vessels..
Evidence also suggests the presence of subgenomic RNA (a surrogate marker of viral replication) in solid tissue obtained months after SARS-CoV-2 infection.
A recent study this year has showed persistence of SARS-CoV-2 viral RNA and sustained (up to 2 years) tissue-based T-cell activation in people with mild-acute COVID-19 [and long COIVD symptoms].
This study also showed the presence of double-stranded RNA (indicating active viral transcription and replication) in some patients up to nearly 2 years following initial infection..
these data suggest ongoing replication or transcriptional activity and possible persistence of active SARS-CoV-2 reservoirs that could drive long-term tissue-based immune disturbances.."
We are living with COVID, literally.
'SARS-CoV-2 antivirals and post-COVID-19 condition'
thelancet.com/journals/lanin…
[Growing] Data from multiple settings have shown evidence of viral persistence (ie, persistence of viral RNA or protein fragments) for months or years in multiple organ systems including the gut, brain, kidneys, and blood vessels..
Evidence also suggests the presence of subgenomic RNA (a surrogate marker of viral replication) in solid tissue obtained months after SARS-CoV-2 infection.
A recent study this year has showed persistence of SARS-CoV-2 viral RNA and sustained (up to 2 years) tissue-based T-cell activation in people with mild-acute COVID-19 [and long COIVD symptoms].
This study also showed the presence of double-stranded RNA (indicating active viral transcription and replication) in some patients up to nearly 2 years following initial infection..
these data suggest ongoing replication or transcriptional activity and possible persistence of active SARS-CoV-2 reservoirs that could drive long-term tissue-based immune disturbances.."
We are living with COVID, literally.
'SARS-CoV-2 antivirals and post-COVID-19 condition'
thelancet.com/journals/lanin…
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