David it Up! Profile picture
Sep 12 3 tweets 4 min read Read on X
Are We Screwed? Bone Marrow Destruction - Covid F’d us?

The world has spent much of the past few years grappling with the visible destruction caused by COVID-19. 

We’ve did see hospitals stretched to their limits, economies brought to their knees, and our daily lives flipped upside down. Now politics are F’ing things up. 

But lurking beneath the surface of this storm is a deeper, more insidious threat—a long-lasting impact on our bodies that many of us aren’t even aware of. And it’s starting in one of the most critical, yet overlooked parts of our anatomy: the bone marrow.

 What’s Happening Inside Your Bones?

Bone marrow is like the lifeblood factory of your body. It’s where your red blood cells are made, providing oxygen to every cell; where white blood cells are formed, fighting off infections; and where platelets are created to stop you from bleeding. In short, it’s the command center of your immune system and the source of the very components that keep you alive.

Now, let’s imagine that factory being hijacked. COVID-19 doesn’t just stop at your lungs or your heart—it can invade the bone marrow itself. The virus and its long-term persistence in the body are now being connected to deeper, systemic damage that stretches far beyond the acute infection stage. It's like having termites quietly chewing away at the foundation of a house. At first, you don’t notice much. But over time, the structural integrity weakens, and one day the whole thing starts to crumble.

 Viral Persistence: A Lingering Menace

Most of us were told that after surviving COVID-19, we’d recover fully and life would go back to normal. But that’s not what’s happening. Instead, a growing body of research is showing that SARS-CoV-2—the virus that causes COVID-19—can stick around in the body long after the initial symptoms fade. This phenomenon, known as viral persistence, is like a slow burn inside the body, quietly continuing its work while the world believes the threat has passed.

And here’s where it gets even more worrying: when this virus lingers in the body, it can disrupt not only the bone marrow but also the entire immune system. Imagine trying to repair a broken house while the damage is still being done—tools go missing, supplies run out, and things keep breaking faster than you can fix them.

 Bone Marrow in the Crosshairs

The viral persistence in bone marrow affects how it produces vital blood cells. When COVID-19 takes root in the bone marrow, it can suppress normal blood cell production. This disruption can lead to problems like anemia (not enough red blood cells), immune system dysfunction (weak or abnormal white blood cells), and clotting issues (platelets aren’t working properly).

People are walking around thinking they’ve recovered, but their immune system is less effective. They're more prone to infections, autoimmune issues, and maybe even blood cancers. It’s like a slow, smoldering fire that’s quietly consuming the body’s ability to defend itself. 

 A Crisis Waiting to Unfold

What does this mean for society? Viral persistence in the bone marrow doesn’t just affect individuals; it has ripple effects across communities, healthcare systems, and the economy. A society with a weakened immune system—millions of people who are more prone to long-term illnesses—will struggle to function. Productivity drops, healthcare costs skyrocket, and the overall well-being of the population declines.

As the virus lingers in bone marrow, it creates a chronic, ongoing assault on the body that undermines recovery. People will take longer to get back on their feet. Or, worse, they may never fully recover. This is where the long-term damage begins to snowball—our healthcare system is not just dealing with acute COVID-19 cases anymore, but an ever-growing wave of chronic health conditions. And these aren’t just statistics; these are real people, families, and communities who will bear the brunt of this crisis for years to come.Image
The Bigger Picture

COVID-19 is no longer just about the number of cases or hospitalizations. It’s about the deeper, hidden damage that viral persistence is doing to our bodies, and to society as a whole. Ignoring the long-term effects of this virus is like looking at a crumbling house and only worrying about a leaky roof. The foundation is cracking, and if we don’t address it soon, the damage will be much, much worse than anyone could have predicted.

What we need is a renewed focus on understanding and treating this viral persistence. We need research, awareness, and action. If we don’t act now, we’re not just dealing with the aftermath of a pandemic—we’re staring down the barrel of a chronic, invisible crisis that could upend society as we know it.

So while the world may be eager to move on, COVID-19 hasn’t left the building. It’s still here, lurking in the shadows of our bones, waiting for us to

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with David it Up!

David it Up! Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @Dave_it_up

Jun 23
Is their evidence for viral persistence in COVID-19?

From the meticulous work of the PolyBio Research Foundation, in collaboration with the esteemed halls of UC San Francisco and Harvard Medical School, to the robust findings published in Nature and The Lancet, we are presented with compelling evidence of the virus’s tenacity. 

These studies not only confirm the presence of viral proteins and RNA months after the acute phase of infection but also suggest a troubling link to the chronic, debilitating symptoms known as long COVID.

Let’s delve into some of the evidence for the evidence pointing to viral persistence of SARS-CoV-2, 

1. PolyBio Research Foundation Study
A study published by the PolyBio Research Foundation, supported by UC San Francisco and Harvard Medical School, found that viral proteins from SARS-CoV-2 could persist in the body for up to 14 months post-infection. This study used an ultra-sensitive blood test to detect viral proteins in 25% of the 171 participants, indicating that the virus can linger in tissues and organs long after recovery from the acute phase of the infection. The likelihood of detecting these proteins was higher among those who were hospitalized or reported severe symptoms during their initial infection[1].

2. Nature Study on Persistent SARS-CoV-2 RNA Shedding
A cohort study published in *Nature* identified persistent SARS-CoV-2 RNA shedding in individuals for at least 30 days, with some cases extending to 60 days. The study found that individuals with persistent infections had more than 50% higher odds of reporting long COVID symptoms compared to those with non-persistent infections. This suggests that persistent infections could contribute to the pathophysiology of long COVID, although the exact mechanisms remain to be fully understood[3].

3. NCBI Study on Long COVID and Viral Persistence
Research published on NCBI proposed a hypothesis-driven model for long COVID, suggesting that the persistence of SARS-CoV-2 or its components (such as the spike protein) could lead to chronic inflammation and a dysregulated immune response. This model is supported by evidence of viral RNA and antigens being detected in various tissues, including the cerebrospinal fluid and feces, months after the initial infection. The study highlights the potential for viral persistence to trigger long-term health issues[2].

4. Lancet Study on Viral Persistence in Tissues
A study published in *The Lancet* examined the persistence of SARS-CoV-2 in various tissues, including blood, gastrointestinal, and surgical samples. The research found that viral RNA and proteins could be detected in these tissues long after the acute phase of infection, suggesting that the virus can persist in different parts of the body and potentially contribute to ongoing symptoms and health complications[5].

5. NCBI Study on Viral Persistence and Reactivation
Another study on NCBI explored the persistence of viral RNA and antigens in patients with long COVID. It found that viral components could be detected in blood, stool, and urine, and that the presence of these components was associated with persistent symptoms. The study also noted that viral persistence might involve either active replication or the presence of non-replicating viral RNA, which could still trigger immune responses and inflammation[4].

The evidence from these studies collectively supports the notion that SARS-CoV-2 can persist in the body for extended periods, potentially leading to long-term health issues such as long COVID. This persistence can involve both active viral replication and the presence of viral components that continue to stimulate the immune system, leading to chronic inflammation and other symptoms. 

Further research should be done to put to rest this question of viral persistence and to develop effective treatments for long-term COVID.Image
Sources
[1] COVID-19 Virus Can Persist in the Body More Than a Year after ...
[2] Long COVID: A proposed hypothesis-driven model of viral ... - NCBI
[3] Prevalence of persistent SARS-CoV-2 in a large community ... - Nature
[4] Viral persistence, reactivation, and mechanisms of long COVID - NCBI
[5] The persistence of SARS-CoV-2 in tissues and its association with ... biospace.com/article/releas…
ncbi.nlm.nih.gov/pmc/articles/P…
nature.com/articles/s4158…
ncbi.nlm.nih.gov/pmc/articles/P…
thelancet.com/journals/lanin…
Someone just let me know that there are actually two more studies that are important. I will post them as soon as I get a hold of them.
Read 6 tweets
Dec 24, 2023
Similarities of HIV and Covid.

A study reveals that SARS-CoV-2 can infect human CD4+ T helper cells, impacting the immune response in severe COVID-19 cases. The virus uses the CD4 molecule to enter these cells, leading to functional impairment and cell death. This infection results in increased IL-10 production in T cells, associated with viral persistence and severe disease. The findings suggest that SARS-CoV-2 infection of CD4+ T cells contributes to immune dysfunction in COVID-19.

elifesciences.org/articles/84790
From Merk manual for healthcare professionals.
Image
Image
Also thanks for graphic @dbdugger
Read 4 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us!

:(