Are We Screwed? Bone Marrow Destruction - Covid F’d us?
The world has spent much of the past few years grappling with the visible destruction caused by COVID-19.
We’ve did see hospitals stretched to their limits, economies brought to their knees, and our daily lives flipped upside down. Now politics are F’ing things up.
But lurking beneath the surface of this storm is a deeper, more insidious threat—a long-lasting impact on our bodies that many of us aren’t even aware of. And it’s starting in one of the most critical, yet overlooked parts of our anatomy: the bone marrow.
What’s Happening Inside Your Bones?
Bone marrow is like the lifeblood factory of your body. It’s where your red blood cells are made, providing oxygen to every cell; where white blood cells are formed, fighting off infections; and where platelets are created to stop you from bleeding. In short, it’s the command center of your immune system and the source of the very components that keep you alive.
Now, let’s imagine that factory being hijacked. COVID-19 doesn’t just stop at your lungs or your heart—it can invade the bone marrow itself. The virus and its long-term persistence in the body are now being connected to deeper, systemic damage that stretches far beyond the acute infection stage. It's like having termites quietly chewing away at the foundation of a house. At first, you don’t notice much. But over time, the structural integrity weakens, and one day the whole thing starts to crumble.
Viral Persistence: A Lingering Menace
Most of us were told that after surviving COVID-19, we’d recover fully and life would go back to normal. But that’s not what’s happening. Instead, a growing body of research is showing that SARS-CoV-2—the virus that causes COVID-19—can stick around in the body long after the initial symptoms fade. This phenomenon, known as viral persistence, is like a slow burn inside the body, quietly continuing its work while the world believes the threat has passed.
And here’s where it gets even more worrying: when this virus lingers in the body, it can disrupt not only the bone marrow but also the entire immune system. Imagine trying to repair a broken house while the damage is still being done—tools go missing, supplies run out, and things keep breaking faster than you can fix them.
Bone Marrow in the Crosshairs
The viral persistence in bone marrow affects how it produces vital blood cells. When COVID-19 takes root in the bone marrow, it can suppress normal blood cell production. This disruption can lead to problems like anemia (not enough red blood cells), immune system dysfunction (weak or abnormal white blood cells), and clotting issues (platelets aren’t working properly).
People are walking around thinking they’ve recovered, but their immune system is less effective. They're more prone to infections, autoimmune issues, and maybe even blood cancers. It’s like a slow, smoldering fire that’s quietly consuming the body’s ability to defend itself.
A Crisis Waiting to Unfold
What does this mean for society? Viral persistence in the bone marrow doesn’t just affect individuals; it has ripple effects across communities, healthcare systems, and the economy. A society with a weakened immune system—millions of people who are more prone to long-term illnesses—will struggle to function. Productivity drops, healthcare costs skyrocket, and the overall well-being of the population declines.
As the virus lingers in bone marrow, it creates a chronic, ongoing assault on the body that undermines recovery. People will take longer to get back on their feet. Or, worse, they may never fully recover. This is where the long-term damage begins to snowball—our healthcare system is not just dealing with acute COVID-19 cases anymore, but an ever-growing wave of chronic health conditions. And these aren’t just statistics; these are real people, families, and communities who will bear the brunt of this crisis for years to come.
The Bigger Picture
COVID-19 is no longer just about the number of cases or hospitalizations. It’s about the deeper, hidden damage that viral persistence is doing to our bodies, and to society as a whole. Ignoring the long-term effects of this virus is like looking at a crumbling house and only worrying about a leaky roof. The foundation is cracking, and if we don’t address it soon, the damage will be much, much worse than anyone could have predicted.
What we need is a renewed focus on understanding and treating this viral persistence. We need research, awareness, and action. If we don’t act now, we’re not just dealing with the aftermath of a pandemic—we’re staring down the barrel of a chronic, invisible crisis that could upend society as we know it.
So while the world may be eager to move on, COVID-19 hasn’t left the building. It’s still here, lurking in the shadows of our bones, waiting for us to
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How to Love Someone With Long Covid (Even When It’s Hard)
Let’s talk about something brutal.
When you get sick and stay sick, people disappear. That’s not a flaw in your personality or your worth. That’s human behavior. Animal behavior, actually.
Let me rewind.
Decades ago, I dated someone I loved deeply. She had this deep belief, that if the passion fizzled, it was over. That was the whole rulebook for her: no fireworks, no future. And maybe when you’re young, that feels like truth. But I had already seen what love actually looks like, the kind where your parents argue. and then hold hands shortly after. The kind where frustration turns into listening, and listening, turns back into love, like some weird emotional tide.
So when she asked me, “Is it over?” I was confused. Like… why would she even think that?
Later, I learned something that changed me.
You don’t have to feel love to show it.
Almost always, the showing comes first.
When you do the loving thing as a caregiver, lover, friend, and cook their favorite meal, run the errand, sit through their bad day, something inside shifts. Love grows out of the act in you. It’s a feedback loop. Not a feeling. A practice. Both of my deepest relationships got stronger the moment I stopped chasing emotional proof and just acted out of little acts of me doing loving things. And you know what? The feeling always followed. I loved them more. I was loved back more.
This is where we bring in Long Covid.
Millions of people have been living through something that most of the world pretends isn’t real. Something that doesn’t show up on the surface, but eats through their body, their energy, their memory, their sense of self. And if they are lucky enough to have a partner, or a parent, or a friend who’s still around, chances are, you are also struggling.
Because illness drives people away.
It always has.
It’s not new. Throughout history, when people got sick, they got abandoned. Leprosy. Tuberculosis. Polio. People didn’t just suffer the disease, they suffered being cast out.
We’re no different. Just more polite about it.
And if you’re the one still here, caring for someone who’s chronically ill, let me say this: Your instincts will betray you. There’s a weird effect that illness has on caregivers. It makes you want to retreat. You’ll find yourself pulling away. Not because you’re cruel. But because your brain is screaming for safety. Normalcy. Simplicity. And right now, the sick person you love is the opposite of that.
This is where I remind you: You are an animal.
I listen to this podcast called Tooth and Claw. It’s full of bear attacks and wild animal stories. One of the hosts says something that stuck with me:
“If you see a behavior in animals across a wide population, it’s probably an animal behavior.”
Well guess what? Caregivers disappearing when someone gets sick, and that’s an animal behavior. Human animal behavior. Our biology is hardwired for survival, and that means distancing from perceived danger. Sickness triggers something ancient in us. Something deep. Something hard to override.
But here’s the thing.
You can override it.
It starts with remembering who they are, not who they are now, in bed, groaning, or angry, or falling apart, but who they were. Who you fell in love with. Who made you laugh until you cried. That version of them still exists, even if it’s buried under symptoms and fatigue and grief.
Remember this too: In sickness and in health wasn’t poetic fluff. That vow wasn’t written for fairy tale weddings. It was a survival pact. It came from generations of people who watched their children die of infections. Who lost partners to fevers. Who suffered and stayed. That phrase was carved out of real history, when illness wasn’t rare (Just look up how many children died pre-1930s) it was expected. And now here we are again.
Modern medicine gave us the illusion that we were safe. That sickness was temporary. That suffering was manageable. But Long Covid shattered that illusion. And most people born after 1960 have no emotional blueprint for this.
We’re flying blind.
If you’re the one who’s sick, here’s something you need to hear: You’re not being ignored because you’re annoying or boring or selfish. You’re being ignored because your suffering triggers something ancient and uncomfortable in people. They don’t know how to sit with it. Most weren’t taught how. Their avoidance isn’t always a conscious choice. It’s an emotional reflex.
In the book How Emotions Are Made, Lisa Feldman Barrett explains that emotions come first, and logic comes after. We don’t decide how to feel — we feel, and then decide based on that. So when your loved one shrinks from your pain, or snaps at you, or stops checking in, ask yourself: Are they choosing that? Or is it an emotional response they don’t even recognize?
Think about the last time you stubbed your toe on something, and shouted at an inanimate object. “Damn it!” That wasn’t a planned reaction. That was your animal brain in action.
That’s what we’re dealing with. Not cold indifference. Biology.
So what can you do?
If you’re a caregiver, do one loving thing today. Not because you feel warm and fuzzy. But because it’s the right thing. Make tea. Rub their back. Sit in the room quietly. Do it even if they don’t thank you. Do it even if they’re upset. Because the feedback loop still works. It works on you. You’ll feel more love just from acting in love.
If you’re a patient, and your family member is cold or distant, try this: If you have the energy, think a loving thought toward them. Even if they’re not giving it back. Just thinking it can soften something inside you. Maybe it leaks out. Maybe it doesn’t. But you’ll feel it. And maybe — just maybe — that loop starts to close.
None of us chose this.
But we can choose how we respond.
We’re not just animals.
We’re animals with memory.
With words.
With stories.
I know I tend to make long posts. I’m going to include an audio version for those who can’t read long posts. For future articles, I’m definitely open to suggestions fiture posts. Should they be shorter or should they be broken up with titles?
Is their evidence for viral persistence in COVID-19?
From the meticulous work of the PolyBio Research Foundation, in collaboration with the esteemed halls of UC San Francisco and Harvard Medical School, to the robust findings published in Nature and The Lancet, we are presented with compelling evidence of the virus’s tenacity.
These studies not only confirm the presence of viral proteins and RNA months after the acute phase of infection but also suggest a troubling link to the chronic, debilitating symptoms known as long COVID.
Let’s delve into some of the evidence for the evidence pointing to viral persistence of SARS-CoV-2,
1. PolyBio Research Foundation Study
A study published by the PolyBio Research Foundation, supported by UC San Francisco and Harvard Medical School, found that viral proteins from SARS-CoV-2 could persist in the body for up to 14 months post-infection. This study used an ultra-sensitive blood test to detect viral proteins in 25% of the 171 participants, indicating that the virus can linger in tissues and organs long after recovery from the acute phase of the infection. The likelihood of detecting these proteins was higher among those who were hospitalized or reported severe symptoms during their initial infection[1].
2. Nature Study on Persistent SARS-CoV-2 RNA Shedding
A cohort study published in *Nature* identified persistent SARS-CoV-2 RNA shedding in individuals for at least 30 days, with some cases extending to 60 days. The study found that individuals with persistent infections had more than 50% higher odds of reporting long COVID symptoms compared to those with non-persistent infections. This suggests that persistent infections could contribute to the pathophysiology of long COVID, although the exact mechanisms remain to be fully understood[3].
3. NCBI Study on Long COVID and Viral Persistence
Research published on NCBI proposed a hypothesis-driven model for long COVID, suggesting that the persistence of SARS-CoV-2 or its components (such as the spike protein) could lead to chronic inflammation and a dysregulated immune response. This model is supported by evidence of viral RNA and antigens being detected in various tissues, including the cerebrospinal fluid and feces, months after the initial infection. The study highlights the potential for viral persistence to trigger long-term health issues[2].
4. Lancet Study on Viral Persistence in Tissues
A study published in *The Lancet* examined the persistence of SARS-CoV-2 in various tissues, including blood, gastrointestinal, and surgical samples. The research found that viral RNA and proteins could be detected in these tissues long after the acute phase of infection, suggesting that the virus can persist in different parts of the body and potentially contribute to ongoing symptoms and health complications[5].
5. NCBI Study on Viral Persistence and Reactivation
Another study on NCBI explored the persistence of viral RNA and antigens in patients with long COVID. It found that viral components could be detected in blood, stool, and urine, and that the presence of these components was associated with persistent symptoms. The study also noted that viral persistence might involve either active replication or the presence of non-replicating viral RNA, which could still trigger immune responses and inflammation[4].
The evidence from these studies collectively supports the notion that SARS-CoV-2 can persist in the body for extended periods, potentially leading to long-term health issues such as long COVID. This persistence can involve both active viral replication and the presence of viral components that continue to stimulate the immune system, leading to chronic inflammation and other symptoms.
Further research should be done to put to rest this question of viral persistence and to develop effective treatments for long-term COVID.
A study reveals that SARS-CoV-2 can infect human CD4+ T helper cells, impacting the immune response in severe COVID-19 cases. The virus uses the CD4 molecule to enter these cells, leading to functional impairment and cell death. This infection results in increased IL-10 production in T cells, associated with viral persistence and severe disease. The findings suggest that SARS-CoV-2 infection of CD4+ T cells contributes to immune dysfunction in COVID-19.