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Kate Wolfstone Profile picture
@AlisaValdesRod1
Oct 13 • 4 tweets • 2 min read • Read on X
This is the most reliable genetic marker for Long Covid susceptibility they found. Lo and behold, I have it. Exactly as they described. Image
Image
However, I do NOT have the second genetic risk factor, which might explain why my Long Covid, while debilitating, has been less severe than other people's. Image
The gene most commonly associated with Long Covid risk appears most frequently in Southern Europe, the Mediterranean and the Middle East, according to chatgpt. Image
Many of my family members in Cuba have Long Covid. My Cuban lineage hails primarily from The Canary Islands and Asturias, Spain. My mostly-Irish and English mother breezed through covid with no lingering issues despite being 80 years old. My son and dad and I all have Long Covid.

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More from @AlisaValdesRod1

Kate Wolfstone Profile picture
Oct 14
The most fascinating thing?

HLA-B*15:01 is a genetic variant that protects people from being symptomatic with covid infection. They breeze through it. No symptoms

HLA-DRB1*11:04, on the same loci, damns people to the hell of Long Covid.

Miniscule shifts. Massive differences.
These genes control, among other things, how a pathogen is seen by the immune system. Imagine the sars2 virus is a narcissistic abuser. HLA-B*15-01 is like, "Oh HELL nah," kicks his ass to the curb. HLA-DRB1*11:04 is like, "I dunno, I like a little danger. I can change him."
What's even worse is HLA-DRB1*11:04 also tells her immune system Sars2 reminds her of her ex. You remember him, right? Harmless cold virus? Fixed him. "Just use the same strategy with the new guy." But new guy doesn't move out. He moves in. He destroys the house. Kills the pets.
Read 4 tweets
Kate Wolfstone Profile picture
Oct 12
This is live on 23&Me. Image
Fwiw, by doing a shit-ton of science reading and diving into my own genomic sequences (in hooes of figuring out why I was still sick), I came VERY CLOSE to this same conclusion in 2022.

This absolutely points to Long Covid as a virus-induced autoimmune disease, like so many others. Here are some of the other diseases associated with a variant of this gene. Lots of overlap with LC.

.sciencedirect.com/science/articl…
Read 4 tweets
Kate Wolfstone Profile picture
Jul 15
I've written a biopic of classical composer Fanny Mendelssohn. I'm trying to find a producer and director now. Fanny lived in the early and mid 1800s, in Berlin. As research, I read books of letters she and her family sent to one another. A 🧵...
They lived in a repressive and ominous time. Every member of the Mendelssohn household was a genius, talented, products of the enlightenment. Witty, compassionate, insightful. Fanny's father, Abraham...
...was a banker and philanthropist. Prussian law limited the jobs Jewish men could hold, and banking, seen as abhorrent, was one of the few allowed. Abraham's father was Moses Mendelssohn, a Jewish philosopher and theologian of the Enlightenment...
Read 26 tweets
Kate Wolfstone Profile picture
May 15
Just saw an author friend's TikTok about the "notes" she got back on her latest book from copy editors at a big publisher. They are weeding out "ableist" DIALOGUE. Characters have to be allowed to speak like people, whether they offend people or not. Otherwise, it's unrealistic.
If readers can't tell that characters aren't the author, we're fucked as a society. I'm writing a murder mystery. Why is the murder allowed, but having the murderer call someone "crazy" isn't? Because readers will now cancel writers if their villains say offensive shit.
Sometimes I have to remind myself the breathe because the utter astonishment at how stupid things have gotten. Yes, stupid. Words evolve and no word means the same thing in one mouth that it does another. People have lost the ability to discern intent and to empathize.
Read 7 tweets
Kate Wolfstone Profile picture
Feb 19
Starting a thread on physical movement/elements that help keep my Long Covid in remission. This is not medical advice, just my story. It's part 4 of a 5-part protocol I created for myself. I have been symptom-free for 10 weeks. If I deviate from any part, symptoms return.

1/n
Please note: I am aware of Post-Exertional Malaise in Long Covid. A recent and oft-cited study points to muscle abnormalities leading to worsening of symptoms with exercise in 25 people with LC compared to 21 people without LC.

But...

2/n
nature.com/articles/s4146…
Image
The study only assessed people with LC who self-reported having PEM to begin with. It was also a VERY SMALL sample size. A study with 8x more participants shows that 40% of people with LC DO NOT HAVE PEM. Not everyone with LC has PEM. Some will have it then not have it.

3/n Image
Read 16 tweets
Kate Wolfstone Profile picture
Feb 18
Starting a thread on medications that help keep my Long Covid in remission. This is part 3 of a 5-part protocol I developed for myself. This is not medical advice, just my story. I'm symptom-free for 10 weeks now.

I will start with the medications & follow with rationale.

1/n Image
I am not getting into dosages because that is highly unique, and no one should take any meds or supplements without medical supervision.

Daily: Xarelto, Famotadine, Cetirizine

Sometimes: Hydroxyzine, prednisone, Albuterol

Finished: Truvada, Metformin, Atorvastatin, Heparin
2/n
Covid and Long Covid can cause blood clots large and small, including microscopic amyloid fibrous clots that clog capillaries.

6 weeks of injected heparin (Lovenox) twice over the past 4 years helped me a lot.

3/n
ncbi.nlm.nih.gov/pmc/articles/P…
Image
Read 16 tweets

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