Conor Browne Profile picture
Oct 17, 2024 1 tweets 1 min read Read on X
From the text:

'COVID-19 can accelerate progression of dementia and induce BBB disruption and inflammatory blood clots causally linked with neuroinflammation and neuronal loss'.

BBB - Blood Brain Barrier.

Neurological sequelae of C-19 will be a huge challenge in the future.

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More from @brownecfm

Jul 14
1. Allow me to clarify, beginning with a definition: by 'rigorous indoor masking' I mean 'wearing a mask in all indoor public spaces'. This, of course, means no eating, although hydration is possible using a sip valve.
2. Why do I write that it can be really difficult? Because acknowledging the sacrifices that people have made as a result of rigorous masking - some for over five years now - to protect both themselves and others is very important.
3. Recognising hardship that people have embraced and continue to embrace for the good of themselves and others lets those people know that their hardship is both seen and appreciated. It is a validation of their efforts. Any leader will tell you how vital this is.
Read 10 tweets
Jul 13
1. Outstanding summary of a recently published study on cognitive dysfunction in Long Covid (link to study at end of thread). The important point here is the 20% prevalence of anosognosia: having cognitive dysfunction but not being aware of it.
2. This was also a finding of the SARS-CoV-2 Human Challenge Study.

From the Discussion: 'This apparent discrepancy between objective and subjective measures could be interpreted as indicating that the tasks are sensitive enough to detect small...
share.google/sh8p64mCjstfgX…
3... changes in cognition that are *too subtle for the volunteer to be metacognitively aware of*'

*my emphasis.

A growing percentage of the global population with cognitive dysfunction that they are not aware of will insidiously change human society.
Read 4 tweets
Jun 27
1. The prevailing discourse surrounding mitigating against SARS-CoV-2 infection is rife with false dichotomies. At a societal level, the most obvious of these is the notion that mitigation measures stand in opposition to economic growth, when, in fact, the opposite is true:
2. Mitigation measures - specifically widespread air filtration or purification - would increase economic growth, by virtue of reducing ill health in the workforce (implementing widespread passive mitigations would also increase operational resilience to future pandemics).
3. Likewise, at a personal level, the prevailing false dichotomy is that mitigating against infection is incompatible with human flourishing. This is also not the case, on two levels:
Read 8 tweets
Jun 23
1. There have been some exceptional comments on this thread, and as a result I'm going to recount a personal experience from 2020 that explains why I come down much harder on the side of incompetence rather than conspiracy.
2. When the UK 'Eat Out to Help Out' scheme was launched in 2020, I told every single person I knew not to take advantage of it. It's important to remember two points here: that this was before the availability of vaccines and that everyone I told knew and trusted my expertise.
3. Only two people I knew didn't take advantage of the scheme (and one of those people still hasn't had Covid). Everyone else basically said something along the lines of, 'I know you're right, but I'm willing to take the risk to have a good night out'.
Read 7 tweets
Jun 4
1. With a new wave of Covid-19 incoming, and remembering my recent comments on the sustainability of risk mitigation, my current protocols are:

Vaccination every six months.

Masking in all shared indoor public spaces.

No masking outside.
2. NAAT testing for all guests (I use PlusLife). If NAAT testing is negative and no-one has symptoms, masks are removed.

I have a small group of friends who take the same precautions as I do; for this group, NAAT testing is not required. I trust them and they trust me.
3. If I need to see a doctor / dentist, or attend a screening procedure, I will attend whether the healthcare staff are masking or not. If I have to take my own mask off for an examination or procedure, I do so. I am all too aware that Covid is not the only risk to my health.
Read 5 tweets
Apr 24
1. This adds weight to a point I've been making for years, namely, that the important differential at the population level between now and the Spanish Flu of 1918-1920 is the considerably higher percentage of the global population who are immunocompromised.
2. People who were immunocompromised as a result of primary immunodeficiencies didn't live long in 1918, because antibiotic therapy didn't exist. Likewise, medication that causes immunosuppression didn't exist either.
3. Additionally, HIV / AIDS didn't exist in 1918. All of these factors explain why there are vastly more immunocompromised people now compared to then. As such, the global immune landscape is much more conducive to viral mutation in this pandemic than it was in 1918 - 1920.
Read 4 tweets

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