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Danielle Beckman Profile picture
@DaniBeckman
Oct 17 • 1 tweets • 1 min read • Read on X
Thank you @AkassoglouLab for putting #COVID19 where it belongs: together with other neurological diseases like Multiple Sclerosis and Alzheimer's disease.
#NeuroCovid
cell.com/cell/fulltext/…Image

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More from @DaniBeckman

Danielle Beckman Profile picture
Jun 21
Our paper is Online and Open Access!

Finally, our rhesus monkey model of Alzheimer's is fully characterized and ready for drug therapy testing! What did we do? 1/5 alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…
Image
Alzheimer’s disease (AD) is a devastating condition with no effective treatments, and promising findings in rodents constantly failing to translate into successful therapies for patients. To develop an AD model closer to humans, we used rhesus monkeys, and targeted the vulnerable entorhinal cortex, delivering a dual tau mutation into the region. During a 3 or 6 months period, we longitudinally collected all possible samples for biomarker analysis:
spinal fluid, plasma, structural MRI, Tau PET Scan and combined these data with high-resolution microscopy analysis of brain tissue. 2/5Image
Related to microscopy, we used a comprehensive panel of antibodies to characterize the profile of Tau-induced pathology in neurons of the Entorhinal-Hippocampus region. 3/5 Image
Read 5 tweets
Danielle Beckman Profile picture
Apr 19
It's #FluorescentFriday!
What happens in the brain during normal aging?
While most neurons will not shrink, they will lose synapses, the connections between different neurons, which can affect learning and memory.
But how do we take these images from primates? (1/5)Image
Since genetic manipulations are hard to perform in primates, we apply an electric current to inject fluorescent dye into individual neurons in this type of image. Check the video below: (2/5)
Microinjection of dye allows us to identify the spines, small protrusions on a neuron that receives input from another neuron. Spine size and shape are linked to memory and learning, and some types are highly vulnerable to normal aging. (3/5) Image
Read 5 tweets

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