“Matthew Fitzgerald, a 28-year-old former engineer at Tesla, described his #LongCovid impairment during a clinic visit: ‘I’m a shell of myself. My physical issues aren’t half as bad as my brain problems. You can say brain fog, but that doesn’t come close to doing it justice.’” 
"There is now ample evidence that both older and younger people with #LongCovid and other infection-associated chronic conditions are at risk of developing #Alzheimers disease and related dementias (ADRD)." nature.com/articles/d4158…
"Over the past 30 years, US$42.5 billion have been spent on Alzheimer’s research, with limited progress."
"The @NIH and other institutions around the world have begun to expand the scope of dementia research to include #LongCovid under the funding umbrella of ADRD."
@NIH "We serve as co-investigators on a soon-to-launch National Institute on Aging-funded phase III trial to test whether baricitinib, an immune-modulating medication, can improve symptoms of patients with ADRD from #LongCovid."
"Brain studies of COVID patients have been.. most revealing science to emerge.. Scans reveal structural changes, such as in regions near olfactory tracts & specific areas of blood–brain barrier, a membrane that protects central nervous system from blood-borne toxins & pathogens."
"Scientists have identified how vagal neurons, which connect the brain to the rest of the body, can relay information about pathogens to the brain stem by increasing or dampening the immune response." #LongCovid
"Many researchers have hypothesized that abnormalities in vagal signalling, potentially set off by the SARS-CoV-2 virus, can drive #LongCovid."
"Vast resources will be needed to untangle how SARS-CoV-2 infection causes #LongCovid and how it might be prevented and treated. This line of research could have major implications for autoimmune diseases, in general, and neuro-inflammatory conditions, in particular."
"Considering that #LongCovid affects more than 5% of people infected with SARS-CoV-2, and the risk that some of these patients will develop a rapidly acquired ADRD, there now exists a critical mass of people to study in this category"
"With sustained investment in #LongCovid research, there is enormous potential to inform future directions in ADRD — an area that in the coming years will contend with rapidly escalating patient numbers expected to reach 139 million globally in 2050, up from 55 million in 2020."
"It is crucial that we do not lose momentum." — @MichaelPelusoMD & @WesElyMD
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