We have a very safe, efficacious paediatric SARS2 mRNA vax, used 6m+.
Reduced dose and age minimises small risk of myocarditis seen in adolescents.
This sobering study by @katebrown220, @chrischirp et al shows 6m+ kids are always at risk from acute COVID.
Maternal antibodies should help protect newborns during the first 6m of life, but this is optimal when mums are vaxd during pregnancy. Sadly, this only happens if your term coincides with a booster campaign 🙄, which is just plain daft. Highlighted many times by @VikiLovesFACS
The first exposure to a pathogen is always the highest risk, no matter what age it occurs.
Whilst kids tend to develop severe symptoms less frequently than adults, this is the wrong comparison and does NOT mean they are invulnerable.
Both short term and long term problems arise.
As per my pinned tweet, the whole point of a vaccine is that it elicits a pathogen specific response with much reduced risk compared to an infection. This usually ensures a more robust response when you DO encounter the critter in question.
Vaccines are consistent and adaptable.
Yes, there's "natural" infection, yes it provides protection, BUT, there's always a cost both in terms of harm at the population scale, as well as inconsistent immunity... viruses like to mess with things, in case you haven't realised by now...
There's also survivorship bias 💔.
But, obviously, JCVI has measured all the pros and cons of including COVID amongst our preschool vaccines, why wouldn't they?
It's not as if u12s kids Vax was a) sold like a damp Squibb by Sajid Javid, or b) unprecedentedly offered for a defined period (in the small print 🤬).
So, while I'm certain this is reviewed regularly, let's make a quick list of costs, benefits, pros Vs cons... 1. Procurement, obviously not cheap, but presumably better once established. 2. Cold chain, distribution. Shame half the school nurses were lost since 2010, really...🤔
3. Losing face... let's face it, this will go completely against the "living with" programme, which is a total shambles regardless WRT therapeutics, #CEV, exposure, etc. 4. Reduced incidence of severe acute disease. 5. Stable platform for ongoing population immunity.
6. Combined with mitigations, and annual boosters in school, reduced transmission. 7. Reduced incidence of #LongCovidKids 8. Reduced incidence of T1D. 9. Reduced neurological, cardiovascular, metabolic, immunological, and other sequelae we're still only learning about...
10. Improved school attendance. 11. Less time off for parents/carers. 12. Fewer kids out of school education over the longer term. 13. Ideally accompanied by educational programmes that help restore/increase vaccine uptake across the board, improving kids and community health.
14. Acceptance that "normal" doesn't mean ideal, or even acceptable when it comes to public health, and that mixed messaging, minimising clear and measurable risks, and conflating public health with "freedom" helps nobody.
So, please, @wesstreeting, ask them to check again? 🙏
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Where was I?
So, let's say the small elite team of virus particles has survived the journey and landed where they want to be...
First, they will encounter innate barriers, eg mucus, which they must cross to physically reach a cell.
There will also be complement, mucosal antibodies (if host is immune), and these can both inactivate and clump viruses together such that phagocytic cells literally eat them up!
So, many of the hurdles from the way out also hit on the way in, and this time, numbers are limiting.
So, viruses need to infect their target cell as quickly as possible before they succumb to defenses.
This mainly depends on the affinity of the viral attachment protein for the cellular receptor used to gain entry. But you have to both unlock the door AND walk through it...
Lots of good debate about virus transmission, yet it's dwarfed by mis/disinformation and lack of nuance, allowing eejits to dismiss the precautionary principle, or, worse, re-run 1980s bigotted attitudes🤬
Viruses don't fit easily into boxes. So, nuances of transmission, a 🧵
I will focus on the example of airborne transmission, but the underlying principles apply to all modes of infection.
Caveat: I research the start/end of the transmission process, but the middle bit is not my forte, so forgive omissions/errors!🙏
See @ukhadds for added nuance!
Right, so I would define transmission as the transfer of sufficient infectious virus from a site of infection or environmental source to an individual, followed by the successful establishment of a productive infection (ie the completion of the life cycle) within the new host.
🚨Anti-vaxxers are twisting a study into mRNA armageddon.
TLDR, all this study says is IF certain groups experienced an adverse event COINCIDENT with vax, then it was more likely to be myocarditis than if taking a different drug🤦♂️
It's behind a pay wall, so will keep brief to save anyone having to read it to stave off the various nutters quoting bizarrely inflated risks of death etc...#LiedSuddenly
Expect it may feature in certain press and on a "patriotic" news channel before long 😉
So, in brief:
1. This is data from JADER, the Japanese equivalent of VAERS, yellow card etc.
Reports of adverse events COINCIDENT with a medicine are made by healthcare workers, pharma, public etc.
Main point, it's a sentinel system used to spot patterns, cases need verifying.
Some issues here...putting it mildly. 1. These are NOT the only high-risk groups. @CDCgov recommend >50s and children as a minimum. 2. This is an influenza strategy, we are NOT in the same place with SARS2 by a country mile. 3. Vax status by age is worrying, 1/3 u40s no vax 😬
4. % of kids u12 vaxd was only ~10% in 22/23 b4 offer was stopped... 5. We age, folks die, and are born. The % population covered by the emergency programme is therefore dwindling across all ages. 6. Yes, our protection vs severe COVID lasts way longer than vs infection, but...
7. Recent study in @JAMA_current shows more recent, better matched vax is better at keeping folks out of hospital. 8. Vax 4 just vulnerable helps en masse, sure, but many r unlikely to make a good response. 9. Poor responders amidst high prevalence will erode protection quickly.
So, the bugs that put me in hospital recently were multi-resistant E. coli. No oral antibiotics would work, so I was on IV for 8 days; 2nd line was looking challenging had the infection not responded.
#AMR isn't a new problem, but the can is continuously kicked down the road...
It's not the same as a pandemic, so I'm not sure about that comparison.
BUT folks need to be reminded that, pre-penicillin and other abx, any wound or infection could be life threatening.
#AMR is via part over-use, part misuse, part inadequate investment into R&D.
In the main, anti-infectives aren't generally looked upon as a good way for pharma to recoup their investment, particularly as new antibiotics tend to be held in reserve nowadays because of the dangers #AMR brings...
This isn't companies being "evil", there's no conspiracy...
Elsewhere in the multiverse there's a reality where the next pandemic threat is under control.
Here, governments recognised that it was their moral duty to ensure that the suffering and pain of those affected, both directly and indirectly, mattered more than the prior status quo.
They rectified #NHS disinvestment and "built back better" to ensure healthcare remained free at the point of care.
They genuinely addressed socio-economic inequality & inequity, channelling sufficient investment to actually "level up" deprived areas, independent of train tracks.
Yes, this involved a tax policy that meant wealthy people paid more, poorer people paid less, and Non-doms paid their dues or were banned.
The poverty gap began to shrink, and the proceeds from taxes weren't wasted on the sorts of companies that populated the VIP list...