Parmita Mishra Profile picture
Nov 22, 2024 19 tweets 6 min read Read on X
we recently saw an insane discovery in biology, which if true, in my opinion, makes extraterrestrial life far far more likely.

🧵 Image
new research suggests that life on Earth became surprisingly complex very early, reshaping our understanding of life’s origins and its implications for the existence of life elsewhere in the universe. Image
a paper about the Last Universal Common Ancestor (LUCA) hypothesis reconstructed the genome of our LUCA, dating it to about 4.2 billion years ago…

…just a few hundred million years after Earth formed 4.5 billion years ago. Image
4.2bn years ago historically was on the earlier end of any estimated age range for LUCA. however, this was the most reliable estimate using sophisticated estimation algorithms for Dr. Moody et al. crucially, they estimated the complexity of LUCA to be higher than anticipated. Image
as per these new models, LUCA wasn’t some rudimentary organism

it possessed a genome encoding approximately 2,657 proteins in a ~2.75 Mb genome

(comparable to modern prokaryotes)

this is unexpected because the popular consensus held that early life was far simpler Image
^ reconstruction (A)

LUCA was not necessarily the first life form, but its complexity suggests that life’s foundation systems (eg molecular synthesis, adaptation) evolved relatively quickly - under favorable conditions

each finding challenges traditional views of evolution Image
LUCA was an anaerobic acetogen, using hydrogen and carbon dioxide for energy via the Wood–Ljungdahl pathway—a sophisticated metabolic process still found in some microbes today. However, LUCA was part of an ecosystem and not an isolated entity. Image
A simpler paper from a few years back with an interesting perspective: sciencedirect.com/science/articl…
based on the reconstruction, LUCA wasn’t photosynthetic but demonstrated notable metabolic flexibility

e.g. capable of both building its own molecules (autotrophy) and using those produced by others (heterotrophy)

this adaptability is astonishing for such an ancient organism
on top of this, there is significant evidence for potential immunity already present at this point.

the tl;dr is that LUCA was remarkably complex very soon into the formation of earth - millions of years in.

which has interesting implications for astrobiology.
We always wonder how long life takes to evolve

If such complex life truly evolved 400mn years into earth’s formation, it is unlikely to be the only form of life by this point. There was likely a molecular arms race* well in motion. Imagine what this means for other planets.
Advancements in astronomy have led to the identification of exoplanets with atmospheric compositions that could support life.

JWST detected methane, maybe DMS and carbon dioxide in the atmosphere of K2-18 b, a planet located 124 light-years away - ie potential habitability Image
Image
similarly, JWST observations of WASP-39 b show the presence of CO2, providing insights into the planet’s formation and atmospheric composition. Image
Image
this already suggests that the building blocks of life, such as water and organic molecules, may be more common in the universe than previously thought - that piece of the puzzle had been recently solved. Image
Specifically, a planet like k218b was formed ~2.5bn years ago. This is relatively young compared to earth - but empirically, we now know it may be old enough for complex life.

Mars, formed around the same time as earth, could be estimated to have ancient microbes earlier too while it was still habitable, if similar models apply.
What are the next steps? While we do not have direct samples of LUCA, we can seriously use this information to figure out the answer to the following question:
if LUCA did adapt these fine tuned characteristics and phenotypes so so quickly, what, external to LUCA, could have caused this?

Can it be other competing organisms? Specific molecules? Did a comet accelerate the development of ancient organisms on earth?
This, coupled with missions like JWST and Europa Clipper, will allow us to answer questions we only thought of in sci-fi movies.
*at a cellular level, this paper posits the following for LUCA:
•Ribosomes for protein synthesis.
•ATP synthase for energy production.
•Likely a phospholipid membrane.
•Evidence of an early immune system akin to CRISPR-Cas mechanisms.

this indicates that LUCA coexisted with early viriod like particles, suggesting molecular arms races were already occurring.

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More from @parmita

Apr 12
your ribosome is not a machine. it’s a computer. and we just found DHX29, which i’d call part of its operating system. thread 🧵 Image
your DNA is an instruction manual written in three-letter words called codons. each word tells the cell which amino acid to add when building a protein Image
but the ribosome — the thing that actually builds the protein — can’t read DNA directly. it reads a copy called mRNA. and it doesn’t go fetch the amino acids itself Image
Read 15 tweets
Apr 1
As someone who actively works in drug discovery, I want to dispel a myth.

Stimulants were not “designed for ADHD.” They were discovered by accident in the 1930s because they calmed hyperactive boys.

Also the origin story of the most prescribed psychiatric drugs in history.
🧵 Image
The entire research pipeline - the clinical trials, the diagnostic criteria, the dosing models - was built around one phenotype: hyperactive boys who couldn’t sit still in class.

Most stimulant studies were conducted on white males. The DSM criteria? Based on young boys. Image
I have ADHD. I’ve had it diagnosed since I was very young. And my meds genuinely helped me. I’m not anti-medication. Stimulants changed my life in real ways. But they fixed my hyperactivity. They did NOT fix my inattentiveness.

That’s not a coincidence.
Read 21 tweets
Apr 1
🚨 There is a new COVID variant: Cicada.

It has spread around 25 US states. <1% prevalence in US but up to 30% of cases in Europe are Cicada.

* carries 70–75 genetic mutations in its spike protein
^ double the amount found in other recent dominant strains like JN.1.
🧵
Why is it called Cicada?

It’s “hibernation” pattern.

In November 2024, it was first detected.

September 2025: waste water detections increase

January 2026: first (human) patient.
Cicada has not yet dominated other strains.

If it does? We are screwed. It could absolutely drive a summer surge.

Crucially, it is more likely to hit older people and the immunocompromised.

Stay cautious!
Read 16 tweets
Mar 21
I just asked myself the most important question I’ve ever asked.

What if, god forbid, I had cancer right now? How would I save my life and would I be able to do it without Precigenetics?

The answer made me cry.

Here’s EXACTLY how I would save my own life TODAY. 🧵
Let me show you both paths. What happens today, without this platform

and what I’d actually do if I had one. Assume I had the permits to use my cells, and I could do what I want.

Then you tell me which world you want to live in.
the current reality for every cancer patient on earth:

You get a biopsy. Your tissue is fixed, stained, and sent to a pathology lab. It’s dead. The cells you need answers from are killed in the process of examining them.

You wait.
Read 32 tweets
Oct 15, 2025
I keep saying “drug discovery” but most of my audience does not understand what this means.

Here’s a thread I worked on over the past week trying to distil down drug discovery - and why it matters in the age of AI.

OPEN THE THREAD 🧵 Image
Drug discovery is how molecules become medicine.
A $180 billion guessing game where up to 97% of candidates fail in trials.

We can now predict protein folds (thanks to AlphaFold), but still cannot simulate what a drug actually does to a living cell in real time.
At its core, drug discovery asks one question:

=> What happens inside a cell when we “perturb” it? (drug it)

Traditional biology answers by destroying the cell to measure it.

Every assay is a snapshot. Every snapshot costs reagents, time, and lives. Image
Read 23 tweets
Sep 26, 2025
how do we know that people in the past had cancer and when did we even know what cancer was?

a word for cancer existed long before microscopes or pathology.

the history of cancer is far more exciting than we realize.

🧵
the idea is older than modern medicine. Hippocrates (400 BCE) used the word karkinos (crab) for tumors with “claw-like” spread. Galen (200 CE) expanded it. the word cancer is a translation of this lineage.
this existed across civilizations

in India, texts like Sushruta Samhita circa 600 BCE described “arbuda”: hard, immobile, enlarging masses that ulcerated and killed slowly. not called “cancer,” but the descriptions line up with malignancies.
Read 16 tweets

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