parm Profile picture
Nov 22 19 tweets 6 min read Read on X
we recently saw an insane discovery in biology, which if true, in my opinion, makes extraterrestrial life far far more likely.

🧵 Image
new research suggests that life on Earth became surprisingly complex very early, reshaping our understanding of life’s origins and its implications for the existence of life elsewhere in the universe. Image
a paper about the Last Universal Common Ancestor (LUCA) hypothesis reconstructed the genome of our LUCA, dating it to about 4.2 billion years ago…

…just a few hundred million years after Earth formed 4.5 billion years ago. Image
4.2bn years ago historically was on the earlier end of any estimated age range for LUCA. however, this was the most reliable estimate using sophisticated estimation algorithms for Dr. Moody et al. crucially, they estimated the complexity of LUCA to be higher than anticipated. Image
as per these new models, LUCA wasn’t some rudimentary organism

it possessed a genome encoding approximately 2,657 proteins in a ~2.75 Mb genome

(comparable to modern prokaryotes)

this is unexpected because the popular consensus held that early life was far simpler Image
^ reconstruction (A)

LUCA was not necessarily the first life form, but its complexity suggests that life’s foundation systems (eg molecular synthesis, adaptation) evolved relatively quickly - under favorable conditions

each finding challenges traditional views of evolution Image
LUCA was an anaerobic acetogen, using hydrogen and carbon dioxide for energy via the Wood–Ljungdahl pathway—a sophisticated metabolic process still found in some microbes today. However, LUCA was part of an ecosystem and not an isolated entity. Image
A simpler paper from a few years back with an interesting perspective: sciencedirect.com/science/articl…
based on the reconstruction, LUCA wasn’t photosynthetic but demonstrated notable metabolic flexibility

e.g. capable of both building its own molecules (autotrophy) and using those produced by others (heterotrophy)

this adaptability is astonishing for such an ancient organism
on top of this, there is significant evidence for potential immunity already present at this point.

the tl;dr is that LUCA was remarkably complex very soon into the formation of earth - millions of years in.

which has interesting implications for astrobiology.
We always wonder how long life takes to evolve

If such complex life truly evolved 400mn years into earth’s formation, it is unlikely to be the only form of life by this point. There was likely a molecular arms race* well in motion. Imagine what this means for other planets.
Advancements in astronomy have led to the identification of exoplanets with atmospheric compositions that could support life.

JWST detected methane, maybe DMS and carbon dioxide in the atmosphere of K2-18 b, a planet located 124 light-years away - ie potential habitability Image
Image
similarly, JWST observations of WASP-39 b show the presence of CO2, providing insights into the planet’s formation and atmospheric composition. Image
Image
this already suggests that the building blocks of life, such as water and organic molecules, may be more common in the universe than previously thought - that piece of the puzzle had been recently solved. Image
Specifically, a planet like k218b was formed ~2.5bn years ago. This is relatively young compared to earth - but empirically, we now know it may be old enough for complex life.

Mars, formed around the same time as earth, could be estimated to have ancient microbes earlier too while it was still habitable, if similar models apply.
What are the next steps? While we do not have direct samples of LUCA, we can seriously use this information to figure out the answer to the following question:
if LUCA did adapt these fine tuned characteristics and phenotypes so so quickly, what, external to LUCA, could have caused this?

Can it be other competing organisms? Specific molecules? Did a comet accelerate the development of ancient organisms on earth?
This, coupled with missions like JWST and Europa Clipper, will allow us to answer questions we only thought of in sci-fi movies.
*at a cellular level, this paper posits the following for LUCA:
•Ribosomes for protein synthesis.
•ATP synthase for energy production.
•Likely a phospholipid membrane.
•Evidence of an early immune system akin to CRISPR-Cas mechanisms.

this indicates that LUCA coexisted with early viriod like particles, suggesting molecular arms races were already occurring.

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More from @prmshra

Nov 1
i had the chatGPT search extension on for about 10 minutes and reverted back to google and some plex. search holds potential, but here's why it's not good enough *yet*.

why: i want as many links as possible when researching. if i want something with context, perplexity will give me a long list of citations with a cohesive answer. chatGPT search is a nice addition to chatGPT itself, but it's not my search engine atm, unfortunately.

also, instead of making it the default search engine, installing an extension that overrides the default on chrome feels suss. but i'm going to wait to see if there's a reason for this.
a few more notes: asking a followup has returned the same answer for me, similar to how perplexity was in its early days. the search query is not fully parsed and understood yet, especially when there's parts to the query.

o1 is a powerhouse. search is a welcome addition, but does not yet hold anywhere close to a competitive advantage.

i don't like that the extension necessarily overrides the search engine until you disable that setting. it's too early to fully commit to something like this and i wish there was so much more in the extension than this setting
also when i exit search in a chat, i want normal gpt back, but it seems to persist being in search mode

i would like the gpt experience well enmeshed into the search chat agent but they are completely distinct from each other
Read 8 tweets
Jul 8
Schrödinger’s “What is Life?” is a book of magic

predicting phenomena decades before they were discovered empirically

the magic of physics : pivotal for developing molecular biology

I’ve read this book tens of times

let’s explore the key predictions.

🧵OPEN THE THREAD🧵Image
aperiodic crystals
the book posited genetic information must be stored in some “aperiodic crystal,”

a stable molecular structure that could encode information in its configuration rather than through simple repetition

Franklin's DNA X-ray crystallography, decades later:Image
this concept vastly foreshadowed the discovery of DNA’s structure and function with remarkable accuracy

DNA double helix, with its precise sequence of base pairs, essentially fits Schrödinger’s description of an aperiodic crystalImage
Image
Read 15 tweets
Jun 15
there's a SIGNIFICANT piece of legislation which could change biopharma in america. no one seems to be talking about it on X.

BIOSECURE aims to decouple from Chinese contract firms. This could affect over 120 drugs in development.

let's talk about it. 🧵
the main issue at hand is the US biopharma's reliance on Chinese outsourcing for cost-effective research.

this comes with risks related to intellectual property (IP) theft and potential ties to the Chinese government. this is what BioSecure is about.
BioSecure is progressing: The House Committee on Oversight and Accountability recently approved an updated draft.

this set a deadline of 2032 for US companies to sever ties with specified Chinese firms like WuXi and BGI Group.
Read 12 tweets
May 28
Heard of Ozempic/Wegovy? These drugs are part of a class of medications called GLP-1 agonists.

In 2023, Science named GLP-1 agonists Breakthrough of the Year for their potential to combat "diabesity", 1 year after JWST won the same award. Let's ask why.

🧵OPEN THE THREAD🧵Image
GLP-1 - glucagon-like peptide-1 - is a hormone that plays a key role in regulating blood sugar levels.

you may have heard of insulin-glucagon dynamics.

GLP1:
- enhances insulin secretion
- inhibits glucagon release
- slows gastric emptying, making you feel fuller for longer.Image
now let's talk incretins: a group of metabolic hormones, including GLP-1 but also GIP, that stimulate decrease in blood glucose

after eating, they enhance insulin secretion in "anticipation" i.e. even before blood glucose levels become elevated

10.1111/j.2040-1124.2010.00022.xImage
Read 23 tweets
May 17
Yes, mitochondria is the powerhouse of the cell.

...but their evolutionary origin is remarkable. Here is a thread devoted to these beautiful, strange structures, present in almost all our cells, allowing us to survive and thrive on earth.

🧵OPEN THE THREAD🧵Image
As per the endosymbiont theory, mitochondria evolved from free-living bacteria (likely proteobacteria) engulfed by a larger host cell over a billion years ago through endosymbiosis.

Symbiosis-between two physically close organisms.
Endo-one inside the other.Image
Capturing the bacterium was just the start - it had to be converted into a true organelle, fully integrated with the host cell.

This required the host to establish genetic and metabolic control over the endosymbiont - organellogenesis.Image
Read 27 tweets
May 10
Marine viruses are remarkably abundant, diverse, and integral to the functioning of ocean ecosystems.

This thread will explain marine viruses and highlight the role of metagenomics in advancing our understanding of these entities. [Adopted from slides from my talk, 2021]

🧵Image
Viruses are small. They have a protein capsid encapsulating genetic material in DNA/RNA.

Most marine phages are double-stranded DNA viruses w/ tailed morphologies~ from 20 nm to 200 nm.Image
Virus replication strategies are intrinsically linked to the nature of their genetic material.

The form of the incoming viral genome dictates the steps and components necessary for successful replication and propagation.

I can do another thread on the different kinds.Image
Read 26 tweets

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