gavin leech Profile picture
Dec 4 42 tweets 13 min read Read on X
breakthroughs of 2024
Primary endosymbiosis found!

(Two discoveries in one; it's also the first eukaryote known to fix nitrogen)science.org/doi/10.1126/sc…
We have what is essentially a 100% effective HIV vaccine (actually a preventative antiviral which lasts 6 months)
nejm.org/doi/full/10.10…
BusyBeaver(5) = 47,176,870. Perhaps the last entry that will ever be found
scottaaronson.blog/?p=8088
NHS gene therapy trial first to give hearing to a deaf child
theguardian.com/science/articl…
"some bacteria... synthesise new genes and associated proteins as a defence mechanism against bacteriophages"

biorxiv.org/content/10.110…
First privately-owned machine to land on the moon.
nytimes.com/live/2024/02/2…

also
x.com/atroyn/status/…
New lifeform identified in the human gut. Function and symbiosis unknown.
en.wikipedia.org/wiki/Obelisk_(…
A baby received a living heart-valve implant for the first time. This is a permanent solution where previously they received a series of "cadaver homografts" as they grew up.

pmc.ncbi.nlm.nih.gov/articles/PMC10…
"Every year, 300 million male chicks are... shredded alive in industrial grinders... in-ovo sexing can determine the sex of a chick before it hatches... unwanted eggs can be destroyed before... the embryo feels pain."

nytimes.com/2024/03/28/cli…
Actually useful AI: AlphaFold has been out for 3 years. What has it done to earn its Nobel? (Yes, drug dev is slow, but we should see something)

A couple of things:
x.com/CameronPasser/…
x.com/albrgr/status/…
x.com/EricDai_BioE/s…
x.com/AliHShaib/stat…
Gears of war: We finally understand the bacterial motor. The rings of protein allow for several gears
nature.com/articles/s4156…
Probably there is "dark" oxygen production 3 miles under the sea
nature.com/articles/s4156…
Self-cleaning, self-cooling window-slash-roof material
nature.com/articles/s4146…
"Today, agonizing searches for a matched [marrow] donor are largely a thing of the past... Cyclophosphamide was first developed in the 1950s for chemotherapy... repurposed to prevent a common and sometimes deadly complication of bone-marrow transplants called graft-versus-host disease"
theatlantic.com/health/archive…
Monkeys have names
science.org/doi/10.1126/sc…
A Google quantum error-correcting code has gone beyond break-even (the logical qubit lasts > twice as long as its physical qubits). Can now get the overall error rate down to one per million, good enough for a real computer.

arxiv.org/abs/2408.13687
We made some mammoth stem cells
npr.org/sections/healt…
Actual useful personalised medicine: NHS does the first trials of vaccines against bowel cancer, breast cancer, lung cancer and melanoma.

england.nhs.uk/cancer/nhs-can…
en.wikipedia.org/wiki/MRNA-4157…
jitc.bmj.com/content/11/Sup…
30 year old asthma drug seems to help against lethal food allergies

nature.com/articles/d4158…
Geothermal might get much much cheaper


(CW: this is PR)
Starting to understand the fly brain connectome

cell.com/cell/fulltext/…
OTC birth control: progestin minipills approved in the US
archive.is/BklDg
Gold's theorem says nothing about language generation
arxiv.org/pdf/2404.06757
First observed entanglement between quarks (as expected)

ncbi.nlm.nih.gov/pmc/articles/P…
Actually useful AI: Deepmind team accurately computes particular quantum states with a deep learning proxy model
science.org/doi/abs/10.112…
The HPV vaccine reduced cervical cancer cases by 84% over the last 16 years

bmj.com/content/385/bm…
Gene-edited pig kidney transplanted into a living patient for the first time

statnews.com/2024/03/21/fir…
A totally new class of antibiotics

ncbi.nlm.nih.gov/pmc/articles/P…
First time we have measured the interior of any exoplanet

nature.com/articles/s4158…
Some gentle black hole formations (direct collapse, without a supernova)

science.ku.dk/english/press/…
nature.com/articles/s4158…
Actually useful AI: a very general matter simulator with deep learning

arxiv.org/abs/2405.04967
Actually useful AI: maths professor credits Claude and o1 with a novel conjecture and proof in graph theory

At least one piece of "non-coding" RNA is actually key to development, as shown by this specific disorder

medrxiv.org/content/10.110…
Functional ultrasound neuroimaging to work out what a monkey motor cortex is doing, eventually for noninvasive brain-computer interfaces

nature.com/articles/s4159…
Actually useful AI: a graph neural network tool made top materials scientists twice as productive, but also 44% less satisfied with their work.

aidantr.github.io/files/AI_innov…
Actually useful AI: 6 new antibiotics designed by monte carlo tree search. Targets a WHO priority pathogen

nature.com/articles/s4225…

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More from @g_leech_

Feb 8
New paper: a big 90-page intro to AI and its likely effects from ten perspectives, ten camps.

The whole gamut: ML, scientific applications, social applications, access, safety and alignment, economics, AI ethics, governance, and classical philosophy of life.

1/18 Image
We inherited the framing (“Ten Hard Problems”) from Eric Schmidt and James Manyika. They conditionalise on success: "if it's 2050 and everything went well, what did we have to solve for that to happen?"

Intended audience: technical people without any ML experience. Image
We spent a chunk of 2022 and 2023 reviewing 1347 papers and talking to 30 experts.

**Importantly, we don’t really cover most of last year’s enormous progress in capabilities and governance.**

(Lesson: moving too quickly for a journal paper to be a very sensible exercise.)
Read 18 tweets
Jan 5
Blogs I found this year
On steps-to-reach-loss, FLOPs-to-reach-benchmark, inference speed, etc, the mixture-of-experts paradigm gets between 2x~5x improvement over a dense baseline. Fundamentally, MoE is unfriendly to low vRAM developers, which describes the vast majority of OSS
152334h.github.io
Gym owner / computer scientist

toddnief.com/articles/
Read 45 tweets
Dec 27, 2023
ML in 2023

(not a calibrated accounting of All Progress, just what caught my haphazard eye)
This thread will of course overfocus on LLMs. At the start of the year, the stochastic parrot hypothesis was rampant. No longer.


thegradient.pub/othello/
At the same time, the memorisation hypothesis also got confirmed. But intelligence involves compression...


Read 31 tweets
Dec 3, 2023
Breakthroughs of 2023
First sample of a deep space object ever brought back to Earth. The great theft begins!

.archive.ph/TEzqH#selectio…
The first act of space warfare occurred one month ago to no acclaim

jpost.com/israel-news/de…
Read 27 tweets
Dec 17, 2022
best playlists I made this year
Foundtrack was an amazing blog that used to make mp3 playlists. It had a big effect on me. Some cuts are so deep that they're not on Spotify, Youtube, Soundcloud, Bandcamp...

open.spotify.com/playlist/1lUfr…
open.spotify.com/playlist/6k7BR…
Latvia turned out great

open.spotify.com/playlist/5MopE…
Read 10 tweets
Dec 16, 2022
notes on Mexico City
Pleasant to just walk around central CDMX. Trees everywhere, dogs, masterpiece buildings - but razorwire, flaking paint and bare concrete too, to make you realise they are masterpieces (not complacent like I am in perfect environs, e.g. Venice)

Full of noise, trees, and art.
The food is as good as you think. Joint first in the world per dollar. Spice optional.

Chilaquiles (like nachos but way better) is a top-tier breakfast. And Chilpa is one of my favourite restaurants, for $5.
Read 19 tweets

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