1/ The mRNA platform must not be a consideration for humans animals or plants! The Lipid Nanoparticles alone are a deal breaker, period! 𧾠
2/ Risk/benefit analysis is key in all medical intervention decisions.
3/ Donât fall for âsafe and effectiveâ without full analysis.
4/ Such decisions require informed consent and transparency. This, from the @CDCgov is medical disinformation (yes Iâm using their own terms).
5/ They ended the biodistribution studies before Cmax was reached. Nothing peaked yet before study was ended.
6/ They knew back in 2014 that the accumulation increases and continues far beyond their study duration.
7/ The very same LNPs in the liver within 15m.
8/ More definitive evidence that the CDC was not honest in their representation of the LBP gene therapy.
9/ the LNP/modmRNA transfer through breast milk, yet as late as 2023 âexpertsâ recommend it during pregnancy!
10/ They knew this going back to 2010.
11/ The LNP carriers can reach the trophoblasts on their own and induce apoptosis.
12/ Just the LNPs alone wreak havoc on the reproductive drive system. Morexreas ns why this platform in healthies is a hard pass!
13/ they knew it wouldnât stay at the injection site, and even called it a #bodyhack and described it as a âfeatureâ.
14/ we know these particles core are the ones used in Pfizer.
15/ where are the tox studies, and teratogenicity, carcinogenicity, genotox studies?
16/ Not for human use, until an #EUA allows more lax regulations to experiment on the once-healthy masses.
17/ and they got away with ignoring their x studies because they classified LNPs as excupients. I even argued with Paul Offit about this distinction, but he is clueless about CMC, and pushed a false narrative.
18/ They cause universal inflammation. So many implications of harm.
19/ Multiple pathway triggers anyone?
20/ LNPs alone triggering foam cells? What implications do they have on platelet, or blood cell formation?
21/ the carrier alone modulates clot formation. What could go wrong with this platform?
22/ This platform alters both innate and adaptive immunity! IgG4 makes recipient more prone to constant infection.
23/ Donât get me started on zeta potential!
24/ When others know itâs dangerous and discontinued development, maybe it should be an indication it may be harmful?
25/25
Was this a good idea to roll out to the worldâs population for an infection that they couldnât even find enough mortality to properly study necessity of such an intervention? I fear an entire generation plus will feel the consequences of such an irresponsible measure.
Was this a good idea to roll out to the worldâs population for an infection that they couldnât even find enough mortality to properly study necessity of such an intervention? I fear an entire generation plus will feel the consequences of such an irresponsible measure.
Weird autocorrect (excipients)
Tox studies. (Autocorrect hates science almost as much as our captured agencies do.)
Great video from my friend GB #Narf
https://twitter.com/Nicolina0815/status/1865848482889597334
More reasons âŚ. Autocorrect
28) Properties of LNPs as an abrasive can also cause physical damage not just biochemical. pubs.rsc.org/en/content/artâŚ
29) pubs.acs.org/doi/10.1021/acâŚ
âFurthermore, LNPs can transfect a variety of immune cells in the bloodstream, such as dendritic cells and macrophages [25]. They can also exit the circulation through fenestrated endothelium or transcytose into different tissues depending on the route of administration and the specific LNP formulation, then circulate there as they are exocytosed after initial cellular uptake [12]. Lipid nanoparticles also induce oxidative stress, which can enhance the release of exosomes (containing the cargo and cationic ionizable lipids) into the external environment and their circulation throughout the body [26]. For example, Wei et al. compared four LNP formulations, Onpattro-like (DI-8), Moderna, and Pfizer/BioNTech-like, and observed differences in systemic leakage of the labelled mRNA into the circulation at 12 hours. Less leakage was observed with the more stable Onpattro-like formulation (13.9%) than with the Moderna formulation (31.4%). Based on these observations and others (Ren, Kent, Maugeri, 2019), we propose that LNPs exhibit various levels of uptake, systemic circulation, transfection, and exocytosis that depend on the formulation, route, and other factors, which occur simultaneously and are overlapping in nature. Moreover,âŻBalcortaâŻetâŻal.âŻ(NanoâŻLett.,âŻ2025,âŻ25,âŻ7682â7689)âŻdemonstrated that conventional radiotracing and fluorescent labeling approaches lack the subcellular resolution required to map LNP distribution accurately, and introduced peptidebased tags that enable reliable visualization of LNP trafficking within cells and tissues.â
pubs.acs.org/doi/10.1021/acâŚ
âFurthermore, LNPs can transfect a variety of immune cells in the bloodstream, such as dendritic cells and macrophages [25]. They can also exit the circulation through fenestrated endothelium or transcytose into different tissues depending on the route of administration and the specific LNP formulation, then circulate there as they are exocytosed after initial cellular uptake [12]. Lipid nanoparticles also induce oxidative stress, which can enhance the release of exosomes (containing the cargo and cationic ionizable lipids) into the external environment and their circulation throughout the body [26]. For example, Wei et al. compared four LNP formulations, Onpattro-like (DI-8), Moderna, and Pfizer/BioNTech-like, and observed differences in systemic leakage of the labelled mRNA into the circulation at 12 hours. Less leakage was observed with the more stable Onpattro-like formulation (13.9%) than with the Moderna formulation (31.4%). Based on these observations and others (Ren, Kent, Maugeri, 2019), we propose that LNPs exhibit various levels of uptake, systemic circulation, transfection, and exocytosis that depend on the formulation, route, and other factors, which occur simultaneously and are overlapping in nature. Moreover,âŻBalcortaâŻetâŻal.âŻ(NanoâŻLett.,âŻ2025,âŻ25,âŻ7682â7689)âŻdemonstrated that conventional radiotracing and fluorescent labeling approaches lack the subcellular resolution required to map LNP distribution accurately, and introduced peptidebased tags that enable reliable visualization of LNP trafficking within cells and tissues.â
pubs.acs.org/doi/10.1021/acâŚ
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