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PwME 4 bioMEdical research Profile picture
@ValeBodi
Jan 12 • 5 tweets • 1 min read • Read on X
“Patients have to recover for days from, for example, emptying the dishwasher. You can imagine what a disabling disease it is, what an enormous impact it has on your life."

“We caused PEM by a bicycle test. These people were then disabled for a month. Which is almost unethical,
but we wanted to find out what happened before and after the CPET 🚴‍♀️ test. What we saw is that the energy factories were not working as well and that the muscles themselves showed abnormalities."

“The same picture applies to the immune cells, the energy factories do not work
properly. Substances that should not actually be present, such as IDO-2, can also cause a lot of damage in the long term."

“We have purified antibodies/immune cells and injected them into mice. The mice that are injected with the cells from Long Covid patients suddenly develop
many symptoms. This indicates that there is a problem with the immune cells of Long Covid patients." Via @LongCovidNL Dr. Brent Appelman PhD #LongCOVID #PEM #MECFS #CPET #ImmunoMetabolism #IDO2
@LongCovidNL Please @UnrollHelper

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More from @ValeBodi

PwME 4 bioMEdical research Profile picture
Sep 29, 2024
The persistence of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) after SARS-CoV-2 infection: A systematic review and meta-analysis ⁦@Dr_M_Guthridge⁩ Results
We identified 13 eligible studies that reported a total of 1,973 LC patients. sciencedirect.com/science/articl…
Our meta-analysis indicated that 51% (95% CI, 42%-60%) of LC patients satisfied ME/CFS diagnostic criteria with fatigue, sleep disruption, and muscle/joint pain being the most common symptoms. Importantly, LC patients also experienced the ME/CFS hallmark symptom, post-exertional
malaise.
Conclusions
Our study not only demonstrates that LC patients exhibit similar symptom clusters to ME/CFS, but that approximately half of LC patients satisfy a diagnosis of ME/CFS. Our findings suggest that current ME/CFS criteria could be adapted to the identification
Read 4 tweets
PwME 4 bioMEdical research Profile picture
Aug 5, 2024
van Campen & Visser going again at the 🫀& 🧠 ground zero of #PwME’s orthostatic intolerance: The cardiac output - cerebral blood flow relation is abnormal in most #MECFS patients with a normal heart rate and blood pressure response during a tilt test. medrxiv.org/content/10.110…
Introduction: Orthostatic intolerance is highly prevalent in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and is caused by an abnormal reduction in cerebral blood flow (CBF). In healthy controls (HC) regulation of CBF is complex and involves multiple
mechanisms including cardiac output (CO), cerebral perfusion pressure, PO2 and PCO2, flow-metabolism coupling, and innervation of cerebral vessels. In ME/CFS multiple other mechanisms have also been identified. Aim of the study: We previously found that both CBF and CO were
Read 4 tweets
PwME 4 bioMEdical research Profile picture
Jun 21, 2024
Her muscles exhibited very high levels of a protein called WASF3 which Hwang knew little about. Checking the literature, though, Hwang – who also knew nothing about ME/CFS – found a reference to WASF3 in an obscure 2011 ME/CFS study. #MECFS #WASF3 meresearch.org.uk/getting-their-…
Hwang and his team began a full-court press on their findings. They found lower oxygen consumption (energy production), a 34% drop in the levels of the cytochrome oxidase enzyme in the mitochondria, and unusually prolonged recovery times after exercise.
Returning the WASF3
protein levels to normal in mice resulted in increased energy. Digging into WASF3 like no one had ever dug into it before, they were able to show that increased levels of WASF3 are associated with reduced mitochondrial energy production.
Heading upstream they found that levels
Read 6 tweets
PwME 4 bioMEdical research Profile picture
Apr 30, 2024
Researchers from the University of Edinburgh discovered that cells from the pelvic wall of women with #Endometriosis have a different metabolism compared to women without the disease. The cells produced higher amounts of lactate, a potentially harmful femtechworld.co.uk/news/endometri…
waste product, which is similar to the behaviour of cancer cells.
The team found that when the cells from women with endometriosis were treated with dichloroacetate, they returned to normal metabolic behaviour.
The scientists also noted a reduction in lactate and an impact on the
growth of endometrial cells grown together with the pelvic cells. #Endometriosis #Metabolism #Lactate #Dichloroacetate
Read 4 tweets
PwME 4 bioMEdical research Profile picture
Jul 24, 2023
Mitochondrial abnormalities in the postviral fatigue syndrome #MECFS: “We have examined the muscle biopsies of 50 patients who had postviral fatigue syndrome (PFS) for from 1 to 17 years. We found mild to severe atrophy of type II fibres in 39 biopsies, link.springer.com/article/10.100…
with a mild to moderate excess of lipid. On ultrastructural examination, 35 of these specimens showed branching and fusion of mitochondrial cristae. Mitochondrial degeneration was obvious in 40 of the biopsies with swelling, vacuolation, myelin figures and secondary lysosomes.
These abnormalities were in obvious contrast to control biopsies, where even mild changes were rarely detected. The findings described here provide the first evidence that PFS may be due to a mitochondrial disorder precipitated by a virus infection.” P. O. Behan et al 1991 #MECFS
Read 6 tweets

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