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charlos Profile picture
@loscharlos
Mar 24 • 14 tweets • 5 min read • Read on X
Best piece I’ve read on Covid’s impact on the brain:

“Scientists have found that those who have had Covid are more likely to have elevated levels in their blood of the same proteins that are prevalent in people with Alzheimer’s disease.” #LongCovid Screenshot of an article headline from Bloomberg reading: “What We Know About Covid’s Impact on Your Brain Scientists worry that persistent cognitive issues caused by Covid signal that a surge in dementia cases and other mental conditions is on the horizon.” Jason Hale March 3, 2025
“5 years after.. researchers are increasingly recognizing the toll Covid can take on brain health. Many of those who have had the disease struggle with persistent issues such as.. cognitive slowing, hindering their ability to work & otherwise function.” bloomberg.com/explainers/doe…
"UK researchers reported early results from a study comparing brain scans taken before & after pandemic.. They discovered signs of damage & accelerated aging in the brain.. even in patients who had experienced mild cases of Covid months earlier." — @jwgale bloomberg.com/explainers/doe…
"For patients already battling Alzheimer’s.. Covid can exacerbate brain inflammation, damage immune cells & accelerate the memory-robbing disease itself. Even previously healthy older adults face increased risk of cognitive impairment & new-onset dementia" bloomberg.com/explainers/doe…
"Mild Covid cases in younger adults have also been linked to brain issues affecting memory & thinking. These symptoms typically fluctuate & tend to worsen after physical or mental exertion, often impairing the ability.. to work & socialize." #LongCovid bloomberg.com/explainers/doe…
"A 2024 study of nearly 113,000 people found greater loss of memory & executive function among people who had been infected at some point by.. Covid compared with those who had never had it" — @jwgale #LongCovid bloomberg.com/explainers/doe…
"The same study found that even mild cases of Covid led to cognitive decline, equivalent to an average 3-point drop in IQ. For those with unresolved symptoms.. the decline amounted to a 6-point decrease in IQ." — @jwgale #LongCovid bloomberg.com/explainers/doe…
"scientists reported.. persistent cognitive effects in a so-called human challenge.. None of the participants noticed any cognitive effects.. However, six further rounds of testing found the infected group had measurable reductions.. compared with those who weren’t infected"
"Some evidence suggests an infection may increase risk of #Parkinsons.. This link is supported by the rise in cases of parkinsonism — a collection of symptoms such as tremors, slow movement, stiffness & balance issues — following a case of Covid" — @jwgale bloomberg.com/explainers/doe…
"A 2022.. study in Netherlands estimated that #LongCovid affects about 1 in 8 people after infection, with vaccination only partially reducing the risk.

By 2024, the condition was estimated to have afflicted around 400 million people worldwide" — @jwgale bloomberg.com/explainers/doe…
"Persistent viral remnants or the initial infection itself may trigger neuroinflammation & disrupt the immune system, causing antibodies and T cells to mistakenly attack healthy brain cells, damage blood vessels, & harm the blood-brain barrier." #LongCovid bloomberg.com/explainers/doe…
"A study published in late 2024 found that the virus’s spike protein can linger in the body for years after infection, particularly in areas around the skull & brain, potentially contributing to the neurological symptoms of #LongCovid." — @jwgale bloomberg.com/explainers/doe…
"A SARS-CoV-2 infection during pregnancy.. may also increase the risk of neurodevelopmental delays in their offspring, though scientists are still working to understand the extent of this risk amid inconsistent findings." — @jwgale bloomberg.com/explainers/doe…
"#LongCovid has disproportionately affected younger adults in their prime — those who drive much of the workforce, productivity and innovation — exacerbating labor shortages and straining economic growth." — 
@jwgale

Link: bloomberg.com/explainers/doe…US CDC graph titled: "Younger Americans Report More Cognitive Disability Rates have increased among US adults ages 18-44 years since Covid-19 emerged Source: US CDC 2022 Behavioral Risk Factor Surveillance System Note: Prevalence of adults experiencing serious difficulty concentrating, remembering or making decisions."

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More from @loscharlos

charlos Profile picture
Mar 21
“For the longest time in the field of immunology, there was the sort of adage that your immune system needs to be tested every now and again to stay strong. That's an old-fashioned idea.” — David Putrino, Icahn School of Medicine at Mount Sinai #LongCovid Screenshot of a quote in CBC article that reads: “For the longest time in the field of immunology, there was the sort of adage that your immune system needs to be tested every now and again to stay strong. That's an old-fashioned idea. - David Putrino, Icahn School of Medicine at Mount Sinai”
“The more new-fashioned and evidence-based idea is that, although your immune system can take on [a COVID] infection, you want to avoid testing it as much as possible because your body is sustaining damage with each infection that it survives.” #LongCovid cbc.ca/radio/quirks/b…
"There is no such thing as a COVID infection without consequence," says #LongCovid researcher, @PutrinoLab

“Beyond #LongCovid, there are also effects that SARS-CoV-2 infections are having on bodies of the general public that manifest in a way that might be viewed as silent.”
Read 12 tweets
charlos Profile picture
Mar 20
“The inconvenient truth is that what happened to me with #LongCovid can happen to anyone after a viral infection. Though my illness has weakened my body, it has only strengthened my resolve to tell others how to avoid the same fate.” — @julialmv Screenshot of an article headline in US news: “5 Years Since the COVID-19 Pandemic, Millions Like Me Are Still Sick Don’t forget the lessons learned: We need vaccines, masks and ventilation to prevent the next pandemic.” By Julia Moore Vogel March 10, 2025
“5 years ago, I was a long-distance runner with seemingly limitless energy.. and an active professional and mother of a busy young daughter. Today, I use a wheelchair to complete daily activities and am mostly housebound” #LongCovid usnews.com/opinion/articl…
“I have only 10% of the capacity to function that I had before COVID. Beyond the day-to-day challenges of feeding myself.. there are even more painful effects. I can’t physically play with my young daughter. I miss weddings, funerals and the chance to meet friends’ children.“
Read 10 tweets
charlos Profile picture
Mar 17
Today is my 5 year anniversary of #LongCovid & it's all the harder as I unexpectedly lost my mom 2 weeks ago. This disease has taken so much from me, and I feel so fucking low. She was my best friend for most of my life, and I wish I could have had more healthy years with her. 🧵
When my mom was 25, she was in a catastrophic car accident that disabled her overnight (I was 2 at the time in the car & had only a scratch on nose) & she needed multiple major back surgeries throughout her life. I was her caretaker for most of my childhood.
She worked until she literally could no longer sit at a desk, then spent 6 brutal fucking years appealing SSDI (ironically I'm now 3 years into my appeal), & dealt with excruciating chronic daily back pain — still, she was always a contagious, joyous riot & inspiration for me.
Read 13 tweets
charlos Profile picture
Feb 21
Must read:

“Nath is among several academic researchers who have sought to repurpose drugs for #LongCovid only to be met with refusals from the pharmaceutical companies that make them. It's not clear why these manufacturers have balked at supplying drugs for these trials.” Screenshot of an article headline in C&EN reading: “Long COVID studies stymied by pharma’s lack of cooperation Academic researchers want to repurpose drugs for the condition. Manufacturers aren’t supplying them” by Rowan Walrath February 19, 2025
"You end up in this situation where nobody's making the commitment, aside from the people who actually want to do the research, and it just becomes this constant circular discussion," @MichaelPelusoMD, @UCSF says. cen.acs.org/pharmaceutical…
@MichaelPelusoMD @UCSF “Avindra Nath believes he has a way to treat certain people with #LongCovid —or at least shed a light on their condition.
Nath, a neurologist with the @NIH, wants to use pembrolizumab to try to help improve the conditions of people with long COVID whose T cells may be exhausted”
Read 38 tweets
charlos Profile picture
Feb 12
“As the pandemic continues and more people become disabled.. Public health professionals need to step up, movement activists and organizers need to mask up, and we all need to be in solidarity for those in the #LongCovid community.” —  @the_tattooedjew thesicktimes.org/2025/02/11/now…
"Several government resources about accommodations for people with #LongCovid have become unavailable in the last week, following purges of government websites and datasets under the Trump administration. These pages offered crucial information about rights under the ADA"
"The AskJAN pages were 'materials that we use regularly with our patients,' said Dana Barnett, a social work master’s student who works at a #LongCovid clinic (and who alerted @thesicktimes to the website change). 'It’s really disturbing to see that they aren’t there'"
Read 9 tweets
charlos Profile picture
Feb 12
“#LongCovid patients exhibit swelling in an area of the brain linked to memory problems, poor concentration & delayed responses during conversations, researchers have found”

“Those with LC or ME/CFS had a larger than normal hippocampus compared with.. healthy participants.” Screenshot of an article headline in Australian Broadcasting Corporation, reading “Long COVID patients show brain swelling linked to memory and concentration problems, study finds” February 10, 2025
“The Griffith researchers, based at the National Centre for Neuroimmunology and Emerging Diseases (NCNED), compared high-resolution MRI brain scans from 17 #LongCovid patients, 29 #MECFS patients, and 15 people with neither condition.” abc.net.au/news/2025-02-1…
“Significantly, lead researcher Kiran Thapaliya said the study, published in the scientific journal PLOS ONE, also found the size of the hippocampus was associated with symptom severity in both patient groups.” #LongCovid
Read 10 tweets

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