Gaurab Chakrabarti Profile picture
Apr 3, 2025 20 tweets 7 min read Read on X
In 1919, a silent killer swept through New York.

Scientists warned: one teaspoon causes blindness - one glass brings death.

But people continued to drink it.

Here's how the U.S. government created the most lethal poison epidemic in history (killing 10.000): Image
In January 1919, the 18th Amendment was ratified.

It prohibited alcohol production and sales across America.

But demand remained strong.

This created a massive black market for bootleg liquor...
With legal sources gone, bootleggers turned to industrial alcohols, like wood alcohol.

But wood alcohol (methanol) turns into formaldehyde and formic acid in the body.

These lead to blindness, organ failure and death.

Why were so many drinking this poison?
Industrial alcohol was still legal - used for manufacturing, cleaning, and other purposes.

Bootleggers bought this alcohol, redistilled it (to remove toxic additives) and then sold it.

In 1926 the U.S. Treasury made a fateful decision that would cost thousands of lives:
They deliberately increased the toxicity of industrial alcohols to discourage their consumption.

By adding toxic chemicals like benzene, kerosene and even formaldehyde.

Their goal wasn't just to sicken – but to kill...
A Treasury official coldly stated:

"The person who drinks this industrial alcohol...is a deliberate suicide."

But this did not stop bootleggers - in 1926, they diverted about 60 million gallons of alcohol.

The results were catastrophic: Image
In 1926 alone, poisoned alcohol sickened 1,200 New Yorkers and killed 400.

The following year, NYC deaths rose to 700.

Christmas 1926 was devastating, with 23 deaths in just two days.

Here's where the story turns even darker...
When confronted with the death toll, the government did not retract - it doubled down.

"Government isn't obligated to furnish drinkable alcohol when the Constitution prohibits it."

They saw these deaths as necessary deterrents... Image
Meanwhile, the chemical industry boomed:

• Industrial alcohol production jumped from 28M gallons in 1920 to 90M by 1925
• Companies profited selling to both industry and denaturing programs

The human stories are heartbreaking: Image
Jazz legend Bix Beiderbecke drank poisoned alcohol in 1928 and never recovered.

He survived initially, but his weakened body succumbed to pneumonia two years later.

Working class communities suffered most...
They were consuming cheaper bootleg liquor.

By 1933 Prohibition ended.

The government-endorsed poisoning had claimed over 10,000 American lives.

This tragedy led to stronger regulations:
The Federal Alcohol Administration Act of 1935 established strict standards for alcohol production.

The Food, Drug, and Cosmetic Act of 1938 gave FDA broader powers to ensure consumer safety.

While prohibition's poisonings represent a stunning failure of government policy...
They offer a powerful lesson.

When we ignore scientific expertise in favor of misguided policies - the consequences can be devastating.

This resonates deeply with me, as I work to transform one of the most important industries that exist today:
The $6T chemicals industry is the invisible backbone of modern civilization.

It's in every product you touch, every building you enter, and every vehicle you ride.

And we now have the technology to reinvent this critical sector...
At Solugen, we're revolutionizing how essential chemicals are made.

Our enzymatic reactions achieve 96% yields (vs. 60% industry average) while eliminating toxic byproducts.

It's the difference between 1919's wood alcohol and today's precision manufacturing...
But chemical manufacturing processes is just one challenge - next there's outdated logistics.

Huge factories far from customers.

We're solving this problem in the same way mini-mills revolutionized steel manufacturing:
Solugen's Bioforges - a network of smaller, cleaner chemical facilities that allows us to:

• slash costs
• increase efficiency, and
• speed up product delivery

This is how we're bringing critical manufacturing back to American soil...
Follow me @GaurabC for insights on:

• Building the Tesla of chemicals
• Industrial innovation opportunities
• Bringing manufacturing back to the U.S.

Let's strengthen America's backbone: the chemicals industry.
Learn how @solugen is reinventing the $6T chemicals industry.

I sat down with @BaillieGifford to discuss:

• Building carbon-negative cities
• The path to cleaner, safer materials
• The future of distributed manufacturing

Full episode:
Video credits (YouTube):

• Prohibition: America on the Rocks | Historical Documentary | Lucasfilm
• What happened when the United States banned alcohol - Rod Phillips
• U.S. Prohibition (1920-33)
• A Man Drank 2 Liters Moonshine In 2 Hours. This Is What Happened To His Eyes.

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More from @Gaurab

May 27, 2025
In 1238, Granada engineers built the perfect water system.

Today, most architects can't replicate it.

They moved water uphill without pumps, electricity, or external power.

Here's how forgotten knowledge could revolutionize cities: Image
Image
It's 13th-century Spain.

Christian armies are conquering Muslim cities across Iberia.

Cordoba fell in a single night. City after city toppled.

But one fortress remained unconquered for 200+ years: Granada's legendary Alhambra...
The Alhambra's secret weapon? Water.

In a masterpiece of engineering, its designers solved an impossible problem:

Moving water 200 meters uphill to a palace high above Granada's river.

The solution reveals engineering genius we've largely forgotten:
Read 16 tweets
May 14, 2025
In 1708, Europe's greatest minds were defeated by... cups.

They had mastered gunpowder, astronomy, and shipbuilding.

But they couldn't replicate China's magical material that glowed and rang like a bell.

Here's how porcelain became history's most protected technology: 🧵 Image
Image
Imagine creating something so perfect emperors would kill for it.

So valuable that entire trade routes were built around it.

So mysterious that Europe’s greatest minds spent centuries trying to reverse-engineer it.

This is China’s white gold story:
The Chinese invented porcelain through centuries of experimentation, beginning around 1600 BCE.

Over 1,500 years, crude proto-porcelain evolved.

By the Tang dynasty, they created a material as hard as stone and as translucent as jade.

No one else came close:
Read 19 tweets
May 13, 2025
In 1935, DuPont's labs made a shocking discovery:

How to create material that didn't exist in nature.

Today, it's in everything from parachutes to spaceships.

Here's how nylon reshaped our world: Image
At Tarkio College, Carothers fell under the spell of chemistry professor Arthur Pardee.

He was so gifted that before graduating, he taught chemistry to his peers.

This dual role, student by day, instructor by night, foreshadowed his genius.

What happened next changed manufacturing forever:
After earning his PhD at Illinois, Carothers made a pivotal move.

In 1927, DuPont hired him to lead research at their experimental station.

This was radical—most labs aimed for incremental gains.

DuPont wanted breakthroughs with no immediate commercial use.

It worked:
Read 19 tweets
May 6, 2025
Engineers said it was IMPOSSIBLE to build:

A 29-story power plant floating in the open ocean.

Now it powers 100,000 American homes through Category 5 hurricanes.

What they discovered changes everything we know about energy: 🧵 Image
Image
Looking at this floating giant, you'd never guess it's actually a city at sea.

Rising 29 stories high, wider than two football fields, and heavier than an aircraft carrier.

It's called "The Amazing Appomattox" - Shell's largest offshore oil platform ever built:
The Appomattox floats 80 miles off Louisiana’s coast in water 7,400 feet deep.

But the real engineering begins 14,000 feet BELOW the seabed.

That’s nearly 25,000 feet - 4.7 miles - from platform to oil reservoir.

What challenges did they face?
Read 20 tweets
Apr 30, 2025
2,000 years ago, a single Indian port could bankrupt Rome.

They traded black pepper worth millions in gold.

Then it vanished for 1,700 years.

Until archaeologists found something strange in an Indian village... Image
Rome's elite craved black pepper from India's Muziris port.

Pliny the Elder lamented Rome losing 50 million sesterces ($150M) yearly to India.

Most wealth flowed there—where Tamil poems say "beautiful vessels" arrived with gold, left with pepper.

The scale was staggering...
Roman ships brought gold, glassware, and wine, returning with pepper, pearls, and spices.

But what made this port remarkable wasn't just what it traded.

It was how it operated...
Read 16 tweets
Apr 28, 2025
He turned scrap metal into a $1.1B empire.

In 1954 the steel giants laughed at his "mini" factories.

Today his method produces 1/3 of the world's steel output (585M tons).

The story of the farm boy who revolutionized steel production forever: Image
Gerald Heffernan grew up in the mountains of British Columbia in the 1920s.

He sold berries, packed mine supplies, and raised rabbits to help his family.

At 13, he walked 10 miles to negotiate a jam factory contract for his family's orchard—a decision that shaped his future:
He used the contract as collateral to buy a truck—despite being too young to drive.

Heffernan then hired a driver to deliver the apples to the factory.

This knack for problem-solving would transform an entire industry.

But first, he needed knowledge to shake things up...
Read 17 tweets

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