Michael Lin, MD PhD 🧬 Profile picture
Jul 6 7 tweets 2 min read Read on X
In case you think cameras can detect cars or people ahead of them through the glare of the sun, or that AI has learned to react to ambiguous situations with the, well, intelligence of humans, read this Image
It's a frightening and sad story (a grandmother was killed) and I'm surprised to find out about it only now.

There's clear evidence from the Tesla's own cameras that no kind of image processing can beat glare (and that FSD lacks all sense of caution)
bloomberg.com/features/2025-…
Glare happens when light rays from the sun get scattered by water or dust in the air at every lit location to new directions. That means air between an object and the camera can scatter sunlight toward the eye or camera.
When the sun is low, even small scattering angles are enough to redirect lots of light toward a camera, from the air between a person and the camera. This means the photon count from glare will exceed the photon count from the (dark side) of the person.

I drew it out below. Image
This is the actual physical refutation of Musk's claim to have solved the problem with photon counting. Photon counting may help model the spatial extent of glare, but if there is a relatively dark object in there (say emitting 1% of the photons vs glare) it's not going to help.
That's where LIDAR helps. Sure, humans don't have LIDAR either, but the marketing and regulatory claim for developing automated/robotic driving is that the robots can do it better.

Also human brains compensate for lack of LIDAR by exercising caution when we can't see ahead...
and FSD obviously hadn't learned that, as apparent in the video.

And I don't even think in humans it's learned so much as instinctive: We have an innate fear not to advance at deadly speeds into locations we can't see.

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More from @michaelzlin

May 18
FDA has granted regular approval to the Novavax vaccine. What does this mean? A lot of things, all good.

1- It proves Novavax has met efficacy and safety criteria to merit approval outside of the emergency use situation.
Novavax is safer than the RNA vaccines, but ironically the RNA vaccines received full approval earlier than Novavax. That meant Novavax was the only COVID vaccine which vaccine skeptics could incorrectly claim was not safe enough to receive regular approval.
2- Novavax will get to participate in annual booster updates on the same terms as the RNA vaccines. This year's advisory committee for booster strain selection has already been scheduled.

3- All health insurers should now cover Novavax.
Read 14 tweets
Apr 18
"Novavax had 1.7 systemic symptoms compared with 2.8 in Pfizer recipients. In total, 43.8% of Pfizer vaccinees reported at least one symptom of moderate or higher grade, compared with 24.2% of Novavax"

@RobertKennedyJr in case you didn't know. It's also more broadly protective. Image
This is the 2nd controlled study to show about half the side effects rate for Novavax vs Pfizer.

Of the 3 covid vaccines, Novavax is the only one still on EUA. Happens it's the smallest of the 3 companies and hasn't hired ex-FDA staffers.

Article below.
cidrap.umn.edu/covid-19/novav…
FDA had a deadline of April 2 (this month) to decide on regular approval for Novavax, and reportedly was going to, except Peter Marks resigned the day before. Sadly he didn't sign the approval before he left. Was different for Pfizer and Moderna, who got early review and approval
Read 9 tweets
Mar 25
Our NIH grant to discover coronavirus antiviral meds was terminated today.

With this grant, we had developed a better SARSCoV2 inhibitor than Paxlovid, and we recently discovered an improved drug that looks better than Pfizer's own second-generation inhibitor. Image
This is part of a complete elimination of COVID19-related research, including on long COVID.

The rationale given is that the pandemic is over.

In reality, people are dying of COVID at several times the rate of flu, and still getting long COVID.

arstechnica.com/health/2025/03…
This goes against RFK Jr's stated intention to concentrate on chronic disease.

Long COVID is a bad chronic disease to get, and there are reports of long COVID cases getting better immediately after treatment by protease inhibitors such as the ones we are improving.
Read 9 tweets
Feb 28
I wish sane writers like David Wallace-Wells (and real scientists) had more influence instead of those with an axe to grind or a conflict of interest to protect. Even within @nytimes, he was given a second-fiddle seat. But he keeps his facts, and perspective, straight. Image
Some excerpts Image
Read 10 tweets
Sep 15, 2024
Yet another study that shows that Novavax-induced Abs clear virus from the upper respiratory tract better than RNA vax-induced Abs.
Novavax beats Moderna, which (transiently) induces higher levels of neutralizing Abs. As I've said before, Abs are much more than neutralization. Ab effector functions do most of the clearing, and Novavax seems particularly good at that.
And this is in the 2-dose Phase 3 trials, before the 3rd "booster" dose that, in RNA vaccines but not Novavax, induces antibody (immunoglobulin) class-switching to the no-effector-function IgG4
Read 4 tweets
Sep 1, 2024
Flew in from Asia today to learn the exciting news that Novavax's JN.1 booster has been approved!

So happy that the delay relative to RNA vaccines is less than a week. People will finally have a choice of RNA vs protein vaccines this fall.

What are the differences?
I made this graphic to show how different vaccine types work (back in 2021).

We can just look at line 1 (protein vax like Novavax) and line 3 (RNA vax).

In protein vax, antigen-presenting cells take up the antigen to activate B cells and Thelper cells.... Image
In RNA vax, your muscles cells take up RNA and translate it into antigen. This process tends to be a bit inflammatory (apparently that's inherent to RNA uptake) so some cells die and release proteins that are also taken up by antigen-presenting cells.
Read 39 tweets

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