Thread by @PrimeBiology

Berberine is the most underrated metabolic enhancer on Earth.

It improves insulin sensitivity, supports fat loss, and blunts cravings.

But quality, dose, and timing are everything.

Here’s what you need to know (& where to get it right)🧵:

Berberine is a natural compound found in plants like barberry and goldenseal.

But what’s wild is how well it mimics the effects of metformin (a prescription drug used for Type 2 diabetes).

Yet, it does this naturally.

So how does it work?

Berberine activates AMPK. An enzyme known as the "metabolic master switch."

AMPK improves how your cells use glucose, increases fat burning, and enhances mitochondrial function.

It’s like a full-body reset button.

Let's talk a bit about blood sugar:

Berberine has been shown to reduce fasting blood glucose by 15–30%.

That’s on par with leading diabetic medications.

It helps your cells become more insulin sensitive, so your body clears sugar efficiently instead of storing it as fat.

One of it's biggest effects?

Cravings seem to disappear.

Berberine slows the breakdown of carbohydrates in the gut and blunts glucose spikes.

So you don’t get that crash that sends you reaching for snacks an hour later.

In clinical trials, berberine has helped:

- Reduce HbA1c (long-term blood sugar marker)
- Lower LDL (bad cholesterol)
- Improve triglyceride levels
- Support healthy weight loss

All without major side effects.

And yes, I said it may support weight loss:

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Berberine improves insulin function and increases brown fat activation (a fat-burning tissue).

In one study, participants lost an average of 5 pounds in 12 weeks, without changing diet or exercise.

So why aren't more people using it?

Because it’s not a shiny injectable with billion-dollar marketing behind it.

But make no mistake:

This is one of the most studied and effective plant-based compounds for metabolic health.

Berberine addresses the root, not the symptom.

Instead of hacking appetite like Ozempic, it:

- Improves how your cells respond to insulin
- Reduces inflammation
- Balances the microbiome
- Boosts mitochondrial health

Here's how to take it:

- 500mg, 2–3x per day, ideally before meals
- Cycled in 8-week blocks (then 2–4 weeks off)
- Pair with milk thistle for liver support
- Best absorbed in capsule or liposomal form

Here's a quick note you should check before using:

Berberine can lower blood pressure and blood sugar, so don’t mix it with similar meds unless cleared by your doctor.

Also avoid taking it long-term without cycling.

It’s powerful, and your body needs periodic breaks.

Berberine isn’t hype.

It’s an evidence-backed molecule with thousands of years of use in Ayurvedic and Chinese medicine.

And now? Modern science is finally catching up.

Fix your metabolism, and the rest of your health follows.

I strive to help you better understand your body and take steps towards better health.

Follow @PrimeBiology & share this thread.

Upgrade your health, increase your longevity.

This is where science meets self-mastery.

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