Daniel Park Profile picture
Jul 22 12 tweets 3 min read Read on X
Long COVID doesn't just pose threat to personal wellbeing, it impacts families, communities, and the national economy.

Recent estimates show it’s sidelined millions of workers, cost trillions in lost productivity, and is quietly reshaping the U.S. labor market and economy. Image
A recent nationwide study found:
- 35 million U.S. adults (1 in 7) have had long COVID symptoms
- 30 million are working-age
- 24 million face mental health or financial strain

This number is bigger than the entire population of Texas.
Link to study: nature.com/articles/s4385…
Lost wages from long COVID:
- $211B in 2022
- $218B in 2023

That’s similar to the GDP of countries like Portugal, Greece, or New Zealand taken away from household incomes.
Job market impact:

- 3.2M full-time equivalents lost in 2022
- 2.3M lost in 2023
~10M working with ongoing symptoms

These are people missing work, reducing hours, reducing efficiency, or unable to hold jobs due to fatigue, brain fog, or chronic symptoms.
Beyond physical impacts, the severe mental health burden is often overlooked.

2–3x higher risk of anxiety & depression

Many face social isolation, income loss, and difficulty accessing care
Harvard economist David Cutler estimates the total cost of long COVID at $3.7 TRILLION:

-$2.2T: lost quality of life
- $1.0T: lost earnings
- $528B: added medical costs

That’s 17% of U.S. GDP, or roughly the cost of the Great Recession.
hks.harvard.edu/centers/mrcbg/…
The SSA has noted a dramatic impact on disability, and the Federal Reserve has noted large-ranging impacts on the economy and workforce dynamics.

federalreserve.gov/econres/notes/…

nap.nationalacademies.org/catalog/27756/…
Beyond unemployment and disability, Brookings notes that Long COVID may be keeping 2–4M people out of work, and lowering hours worked by tens of thousands of FTEs.

That’s a major drag on productivity not captured in the unemployment rate alone.

brookings.edu/articles/new-d…
Long COVID is not a fringe issue. It impacts society widely and is affecting employment, mental health, monetary policy, and long-term economic growth.

We need interventions and policy solutions that match the scale of the problem.
To start, we need to:
- Prevent infections through vaccines & cleaner air
- Maintain surveillance and tracking systems for COVID (acute & Long)
- Expand Long COVID clinics & facilitate access
- Continue research on treatments
- Support affected families
For more on policy and research, please refer to the excellent review by @EricTopol , @zalaly , @VirusesImmunity and others.
nature.com/articles/s4159…
An ounce of prevention is worth a pound of cure.

For COVID & Long COVID, simple steps like improving vaccine uptake, selective masking, & better air filtration in schools and communal settings can protect individuals, communities, and significantly boost the economy.

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More from @Daniel_E_Park

Jul 13
Interesting new study comparing individuals with ME/CFS, Long COVID, and healthy controls using MRI spectroscopy, cognitive tests, and metabolites. Image
ME/CFS patients had higher lactate in pgACC & dACC, hinting at mitochondrial dysfunction & anaerobic metabolism. Long COVID patients showed lower total choline in dACC, possibly tied to clotting & brain fog.
nature.com/articles/s4138…
Cognition: In ME/CFS, higher lactate correlated with worse verbal fluency. In Long COVID, lower choline linked to poorer executive function. No significant differences in muscle metabolites. Image
Read 5 tweets
Jul 4
The Novavax COVID-19 platform results in lower relative levels of IgG4 compared with mRNA.
IgG4 is additionally linked with lower neutralizing antibody & Fc effector functions.
Lower levels of immune imprinting also seen with NVX, highlighting further benefits of the platform. Image
Link to study:
"Overall, IgG4 levels were notably higher (>150x) in participants primed by mRNA vaccines (8567.1 ng/mL) compared with those primed by the rS protein–based vaccine (48.7 ng/mL)."journalofinfection.com/article/S0163-…
And link to my prior thoughts on the pre-print:

In short, the Novavax vaccine drives a robust immune response, with higher IgG3 antibodies compared w/ mRNA vaccines. IgG3 is key for potent neutralization & Fc-effector functions like phagocytosis
Read 5 tweets
Jun 9
Additional findings from the PREVENT novavax randomized trial on the 4th sequential dose:
- Robust and durable immune responses (8+ months)
- Original strain vaccine had cross protection vs. strains circulating 3 years later (BA.5, BQ.1.1)
- Low reactogenicity (side effects) Image
Durability is notable. The antibody levels 8 months after the first booster were similar or higher than levels after the primary series, in both adults and adolescents. Image
Read 9 tweets
May 28
Folks have asked me about how I feel about this. Honestly, just sad.

Sad that health has become a political football.
Sad for all the infants who will suffer from preventable illness.
Sad that more children will not have the option of preventing long COVID.
It's common sense and good science that infants do not have the natural immunity that protects the vast majority of the rest of the population.

Studies agree infants and the elderly are at highest risk of severe disease.
cdc.gov/mmwr/volumes/7…
Simply, recent variants appear milder largely because nearly everyone has vaccine and/or infection acquired immunity. Newborns do not have this and thus the risk remains similarly high as people's first infection. Maternal immunization provides antibodies

onlinelibrary.wiley.com/doi/full/10.11…
Read 10 tweets
May 20
Marty Markary and Vinay Prasad (FDA Chief and CBER Director) released their perspective on COVID-19 vaccination in a NEJM piece today, with an accompanying webcast.

My quick thoughtsnejm.org/doi/full/10.10…
First, I think they raise some reasonable points. I support their goal of increasing trust in vaccines. They do point out young children as having higher risk with COVID infections. They see significant antigenic shifts requiring broad booster uptake.
I have a few concerns as well. A recurring theme on the webcast was being able to provide individual guidance. I agree that booster decisions are ideally individual. However, if the proper evidence base is there, restricting authorization simply limits choice.
Read 8 tweets
Apr 24
Large study in children and adolescents shows that SARS-CoV-2 infection is linked with long term cardiovascular complications Image
Study is part of the RECOVER consortium with over 1 million kids.
Link to the paper: nature.com/articles/s4146…
Children and adolescents with SARS-COV-2 infection had higher risk of heart failure, chest pain, myocarditis, cardiac arrest, among others. Nearly double the risk of any outcome with infection. Image
Read 7 tweets

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