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P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
@Mangan150
Jul 28 • 8 tweets • 3 min read • Read on X
The cholesterol hypothesis has been wreaking havoc on human health for 75 years.

This is the idea that higher cholesterol levels, especially LDL, are causally linked to “clogged arteries” and heart disease.

Let’s debunk once again:
Optimal total cholesterol levels are higher in than what current medical dogma states.
Lowering cholesterol is a bad idea if you care about brain health:
Higher total cholesterol is better than low total cholesterol when it comes to death rate (pretty important metric if you ask me!).
Now let’s move on to LDL, the so-called “bad” cholesterol.

Personally I think it’s nonsense to call it the bad cholesterol, since when you have more it, cancer risk can go down by as much as 75%.
People with higher LDL tend to live longer:
If you want to avoid plaque and heart disease, LDL (or apoB) aren’t what I’d worry about.

My focus would be on eliminating insulin resistance, and thus getting in excellent metabolic health.

The best way to get in excellent metabolic health is to get lean, fit and strong.
Here’s what I consider to be the most important health markers.

You’ll notice a cholesterol/lipid panel isn’t useless. But the important data points aren’t total and LDL cholesterol. It’s HDL cholesterol and triglycerides that I consider important.

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More from @Mangan150

P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Jul 23
The two words that matter most for those who want to improve their health, mood, energy levels and quality of life:

Body composition.

Let’s define it:
Body composition refers to the components that make up your total weight.

There are a few ways to think about the components, the best one in my view being the three-compartment model which includes:

Bone
Fat
Fat-free mass
Fat free mass includes both muscle and organs.

When we talk about getting to and maintaining a low body fat %, it’s generally calculated as:

Fat mass divided by total weight (all three components).
Read 7 tweets
P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Jul 9
The most common reason older men have lower testosterone levels?

It’s not because they’re older.

It’s because they’re fat.
25% of men over 75 have T levels on par with high T young men.

What's stopping all men from having T levels that high?

Carrying excess body fat, and not training correctly.
I think a lot of men (and their doctors) are too quick to jump on the TRT wagon.

Get rid of excess body fat and build a little muscle…

And odds are good you could have naturally high T levels.
Read 4 tweets
P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Jun 17
If you’re going to take away one core idea from reading my posts, it should be this:

Metabolic health = controllable health.
A second core idea is that WHAT you can control by getting in, and staying in good metabolic health is… a lot.

We’re talking about obesity, diabetes, heart disease, fatty liver, visceral fat and many types of cancer.
A third idea:

Your body composition, meaning the relative degree to which you’re lean and muscular, is highly linked to your metabolic health.

If you’re lean (not skinny-fat, overweight or obese) and have some muscle, it’s highly unlikely that you’re in poor metabolic health.
Read 9 tweets
P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Apr 16
A friend asked ChatGPT what were the most important non-consensus things it has picked up in health, longevity, and healthspan.

First 4 are things I've been talking about a long time.

I'm kinda stunned.

In the follow up, the Chat gave me credit.Image
Image
ChatGPT references

1. Iron as a longevity target

The fine control of body iron stores would be a wise strategy for chemoprevention of several diseases. Image
Glycine and aging: glycine extends lifespan. Image
Read 5 tweets
P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Apr 14
More muscle means lower risk of diabetes

Every 1% decrease in appendicular (legs and arms) muscle mass in proportion to body weight is associated with 30% increased risk of diabetes.

Build muscle and stay healthy. Image
In reality, the increased risk of prediabetes and diabetes with age is almost entirely due to

*increased body fat
*less muscle
*less exercise

Don't gain body fat, build muscle with resistance training, and stay physically active.
You lose muscle as you age.

In old age, someone can have lost 50% of the muscle they had when young.

You can prevent this through resistance training.

Get plenty of protein too. Image
Read 4 tweets
P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Mar 31
Could we prevent most cancer cases?

My answer is yes.

Here's why:Image
We know that cancer rates increase dramatically with age.

About 90% of all cancers happen to people over the age of 50.

For age 70 and up, it’s 50% of all cancers.
Now we must ask, why does almost every cancer case happen later in life?

Could it be linked to metabolic health, the way most serious diseases are? Image
Read 12 tweets

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