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Friesein Profile picture
@Friesein
Aug 4 • 5 tweets • 2 min read • Read on X
"Workers may be exposed via inhalation...

Environmental contamination with infectious virus adds risk of broader spread to wildlife and human populations."

This quote is about H5N1 but it is just as relevant to COVID.

We need to engineer aerosol safety into farms and offices.
We should be conducting field studies of far-UVC on farms to reduce transmission of influenza.

Evidence suggests that far-UVC provides broad protection against viruses that transmit through aerosols.

deconline.pl/wp-content/upl…Figure 2: Far-UVC protects pigs against airborne transmission of PRRS. The pen on the left illustrates the results for the non-irradiated control pigs, in which half of the pigs contracted PRRS from the air. Red pigs denote PRRS- positive, and white pigs denotes PPRS-negative. In contrast, when far-UVC was applied, none of the pigs contracted PRRS, as shown in the pen on the right.
"The application of far-UVC is not limited to pig farms and PRRS; it extends to mitigating any airborne disease in livestock farms.

It can effectively inactivate swine influenza... as well as [inactivating] avian influenza... [and reduce] airborne transmission from wild birds."
And it's not just effective against one virus. It's effective against transmission of a long list of viruses, bacteria, and fungal species.

uvagri.com/articles/trans…Broad-Spectrum Efficacy Laboratory and in-barn studies confirm that 222 nm far-UVC effectively inactivates key swine and poultry viruses—including PRRSV, H1N1 and H9N2 strains—as well as a wide range of bacteria and fungal spores. The technology’s broad-spectrum reach addresses not only acute viral threats but also persistent biofilms and airborne bacterial loads. This comprehensive microbial reduction fosters healthier barn environments, cutting down on disease transmission routes that conventional air filtration or manual cleaning alone cannot fully address.
Why wouldn't we engineer aerosol safety into indoor spaces?

It's no different than treating the water supply before it reaches your tap.

Infectious disease is not an inevitable problem. At the very least, we could make things much better by reducing transmission of pathogens.

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More from @Friesein

Friesein Profile picture
Jul 28
The established order had a choice between short-term financial expediency and public health.

They chose financial expediency. 🧵
This is when the die was cast.

From that point onwards, there was a massive, concerted effort to shift media narratives to encourage mass infection, supposedly as a pro-business move.

Predictably, that was a disastrous decision in terms of public health outcomes.

Read 14 tweets
Friesein Profile picture
Jul 3
30 staff scientists at the FDA had signed off on approving Novavax for anyone 12 or older.

They had reviewed multiple clinical trials with 30-45K participants, showing no more than 3 total cases of myocarditis.

Then Vinay Prasad overruled them and limited access to 65+. 🧵
Anyone who has seriously followed the research on COVID will tell you that the risk of myocarditis (among numerous other conditions) from COVID is far greater than that of Novavax.

Yes, that includes Omicron and later variants.

Put aside spike protein for a minute.

The 3CL protease, a critical part of the viral machinery that allows SARS-CoV-2 to replicate, binds with hundreds of proteins in the liver and gut alone.

And that's just scratching the surface.

Read 13 tweets
Friesein Profile picture
Jun 12
Novavax Availability Update 📢

Costco in Little Rock, AR has reportedly confirmed that they'll have Novavax stock in place by September.

My gut feeling is that this is much closer to the timeline we'll end up seeing for most stores instead of July/August.

Here's why. 🧵
In 2024, the first CVS I heard of that had received their stock was in Pittsfield, MA on September 9.

For Costco, it was in Limerick/Sanatoga, PA on September 13.

Prior to that, the national Costco distribution center had received their stock on September 10, and they began shipping to stores shortly afterwards.

Read 7 tweets
Friesein Profile picture
Jun 11
Novavax Availability Update 📢

I've heard several reports that some Costco pharmacies are expecting Novavax supply between July and the end of August.

I recommend checking with Costco via their web app to find out when you'll be getting it in your area (instructions below). 🧵
Here's how to contact Costco corporate for pharmacy inquiries.

I recommend doing this over talking to your local pharmacy because stores are not always in the loop on shipping status.

Doing this also sends a demand signal to Costco for ordering stock.

Image
This will be the first time Novavax is available outside of Emergency Use Authorization.

Getting access to it this year may require a bit of extra effort, since the new license stipulates that most must have an underlying condition to access the vaccine.

Read 10 tweets
Friesein Profile picture
May 29
This is NB.1.8.1.
So is this.

And some of the symptoms like intense throat pain and fatigue seem to kick in a week or so after the first appearance of symptoms.

Read 11 tweets
Friesein Profile picture
May 23
SARS-CoV-2 is known to bind with mitochondrial proteins in humans.

Mitochondrial dysfunction caused by COVID persists past the acute phase.

Evidence of ongoing mitochondrial and metabolic dysfunction has been found in the heart, kidneys, liver, and lymph nodes, for example. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral proteins bind to host mitochondrial proteins, likely inhibiting oxidative phosphorylation (OXPHOS) and stimulating glycolysis.
These data suggest that when the viral titer first peaks, there is a systemic host response followed by viral suppression of mitochondrial gene transcription and induction of glycolysis leading to the deployment of antiviral immune defenses. Even when the virus was cleared and lung mitochondrial function had recovered, mitochondrial function in the heart, kidney, liver, and lymph nodes remained impaired, potentially leading to severe COVID-19 pathology.
In the case of SARS-CoV-2, it was shown that mitochondria appear swollen and damaged in skin biopsies from patients, and that depletion of mtDNA in endothelial cells significantly reduced the type I IFN response62. In SARS-Cov-2 infected cells, viral RNA was found to be associated with mitochondria using fluorescence and electron microscopy31. Several reports have suggested the colocalization of mitochondrial-SARS-CoV-2 RNA in infected human tissue.
According to recent studies, SARS-CoV-2 infection causes prolonged disruptions in mitochondrial function, significantly altering cellular energy metabolism. Our research employed transmission electron microscopy to reveal distinct mitochondrial structural abnormalities in Long COVID patients, notably including significant swelling, disrupted cristae, and an overall irregular morphology, which collectively indicates severe mitochondrial distress.
There seems to be an inverse relationship between viral load and the expression of mitochondrial genes during the acute phase.

Could the same be true of the chronic phase? Could persistent virus be causing ongoing mitochondrial dysfunction? Mitochondrial gene expression was reduced in autopsy tissues from patients admitted to the hospital with high compared with low viral loads, which confirmed that the extent of altered mitochondrial gene expression may be regulated by viral load (fig. S5). Down-regulation of mitochondrial pathways in response to virus in human autopsy samples was most extensive in hearts followed in decreasing order by the kidneys, livers, and lymph nodes (fig. S5). This inhibition of mitochondrial gene expression in visceral autopsy tissues parallels that seen in the nasopharyngeal samples with high viral t...
Overall, autopsy heart tissue from patients with SARS-CoV-2 infection showed a systematic down-regulation of genes involved in multiple mitochondrial functions; this was also found, to a lesser extent, in kidneys and livers and, to the least extent, in nasopharyngeal samples and lymph node autopsy samples. The lung autopsy samples showed down-regulation of CoQ synthesis and mtFASII but up-regulation of genes involved in the TCA cycle and cytosolic protein import (Fig. 3A).
It is clear is that SARS-CoV-2 is capable of causing mitochondrial damage that persists for months or even years.

And we independently know the virus persists in some form, chronically.

For patients, this means that new symptoms can appear after acute COVID infections. Image
We have observed an interesting phenomenon in the mitochondria, the swollen and vacuolated mitochondria, distorted and broken cristae, all indicated severe damage to this important cellular organelle. This damage is highly likely caused by the SARS-CoV-2 Infection, as we have found an almost identical mitochondria disorganization in the mice that were infected with SARS-CoV-2. Our findings are consistent with a recent study in which mitochondrial gene expression was analyzed in autopsy tissues from patients with COVID-19, and core mitochondrial gene expression were suppressed in the hearts,...
Image
Highlights: - SARS-CoV-2 spike protein persists in the skull- meninges-brain axis in COVID-19 patients. - Spike protein is sufficient to induce brain pathological and behavioral changes in mice. - Spike protein enhances brain vulnerability and exacerbates neurological damage in mice. - mRNA vaccines reduce, but do not eliminate, the spike burden
Read 6 tweets

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