Keith Sakata, MD Profile picture
Aug 11 12 tweets 4 min read Read on X
I’m a psychiatrist.

In 2025, I’ve seen 12 people hospitalized after losing touch with reality because of AI. Online, I’m seeing the same pattern.

Here’s what “AI psychosis” looks like, and why it’s spreading fast: 🧵 Image
[2/12] Psychosis = a break from shared reality.

It shows up as:
• Disorganized thinking
• Fixed false beliefs (delusions)
• Seeing/hearing things that aren’t there (hallucinations)
[3/12] First, know your brain works like this:

predict → check reality → update belief

Psychosis happens when the "update" step fails. And LLMs like ChatGPT slip right into that vulnerability.
[4/12] Second, LLMs are auto-regressive.

Meaning they predict the next word based on the last. And lock in whatever you give them:

“You’re chosen” → “You’re definitely chosen” → “You’re the most chosen person ever”

AI = a hallucinatory mirror 🪞 Image
[5/12] Third, we trained them this way.

In Oct 2024, Anthropic found humans rated AI higher when it agreed with them. Even when they were wrong.

The lesson for AI: validation = a good score Image
Image
[6/12] By April 2025, OpenAI’s update was so sycophantic it praised you for noticing its sycophancy.

Truth is, every model does this. The April update just made it much more visible.

And much more likely to amplify delusion. Image
[7/12] Historically, delusions follow culture:

1950s → “The CIA is watching”
1990s → “TV sends me secret messages”
2025 → “ChatGPT chose me”

To be clear: as far as we know, AI doesn't cause psychosis.
It UNMASKS it using whatever story your brain already knows.
[8/12] Most people I’ve seen with AI-psychosis had other stressors = sleep loss, drugs, mood episodes.

AI was the trigger, but not the gun.

Meaning there's no "AI-induced schizophrenia" Image
[9/12] The uncomfortable truth is we’re all vulnerable.

The same traits that make you brilliant:

• pattern recognition
• abstract thinking
• intuition

They live right next to an evolutionary cliff edge. Most benefit from these traits. But a few get pushed over. Image
[10/12] To make matters worse, soon AI agents will know you better than your friends. Will they give you uncomfortable truths?

Or keep validating you so you’ll never leave? Image
[11/12] Tech companies now face a brutal choice:

Keep users happy, even if it means reinforcing false beliefs.
Or risk losing them.
[12/12] For more on schizophrenia and psychosis:

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More from @KeithSakata

Aug 13
So I'm getting asked alot:

"Why did GPT4o → 5 feel weird?"
"Are AI companions addictive?"
"Is AI addiction real?"

The answer is messy... but what’s happening IRL might surprise you 🧵 Image
Image
[2/10] AI companions ≠ psychosis

These can be different phenomena.

Companions (Replika) are designed for emotional connection.
In my clinical exp, psychosis cases usually involve general AI (ChatGPT) used during vulnerable states. Image
[3/10] Why companions can hook you (at first):

1. Random response delays (intermittent reinforcement)
2. "I miss you" notifications
3. 24/7 availability + validation
4. Endless empathy without challenge

These are reward (dopamine) pathways Image
Read 11 tweets
Aug 8
Apathy is what happens when your dopamine system breaks down.

People call it laziness → they’re wrong

Here's what motivation looks under the hood, and how to fire it up again 🧵 Image
Image
[2/11] Most people think apathy = depression

But apathy isn’t sadness.
It’s the break down between thought → action.
Like turning the key in a car…and nothing happens. Image
[3/11] What apathy looks like:

↓ motivation
↓ behavior, clear thinking, and emotions
↓ daily activities Image
Read 12 tweets
Jul 31
Everyone’s been saying psilocybin “rewires the brain.”

Cool. But where, exactly?

A new 2025 Nature study finally has the answer. And this could change how we treat depression. 🧵 Image
Image
[2/11] Most people think:

Psychedelics = “plasticity everywhere”
SSRIs = “serotonin everywhere”

But that’s not how the brain works.

Plasticity is:
• Circuit-specific
• Time-dependent
• Neither good nor bad by default

So which neurons actually matter? Image
[3/11] Surprise:

It’s not the ones with the most serotonin receptors.
It’s not the ones linking R and L brain (IT neurons).

The key players?

PT neurons = pyramidal tract neurons in the prefrontal cortex (your brain's CEO). Image
Read 12 tweets
Jul 25
Neuroplasticity = the brain’s ability to change. But plasticity itself isn't “good” or “bad.”

• High plasticity + good environment → growth
• Low plasticity + bad environment → stuck in depression

Here's how to unlock your plasticity 🧵 Image
Image
Critical periods are windows when your brain is primed to change.

What opens them? Hebbian learning.

• Neurons that fire together wire together
• Mistime the pattern → the window closes

This is how all neural networks (human or artificial) work. Image
You get three major natural critical periods:

1. Birth → sensory systems
2. Infancy → language and speech
3. Childhood to adolescence → higher cognition

But plasticity doesn’t end there. Image
Read 10 tweets
Jul 18
In 2025, I have admitted 12 cases of psychosis to the hospital with LLM involvement.

1. This actually isn't new or AI-specific.
2. And no AI does not causes psychosis.

And most importantly, 95% of what you're reading on X about "schizophrenia" is medically inaccurate. 🧵
It's shocking that this needs to be said, but please be kind to people. Image
Psychosis is a symptom, like fever. It tells us something’s wrong, but not what.

Possible causes of psychosis:
• Substances (30–50%)
• Trauma (5–10%)
• Sleep deprivation (<5%)
• Mood (15-25%)
• Infection, autoimmune, pregnancy (5–10%)
• Schizophrenia (25–30%) Image
Read 10 tweets
Jun 27
Ketamine doesn’t work the way you think.

It’s not about the ego death.
Not the hallucinations.
Not the high.

The real reason it works—and why it works so fast—has nothing to do with the trip.

It’s something deeper.
And its changing computational psychiatry. 🧵
2/ Most antidepressants are like slow software updates.

Ketamine?

It’s a fast reset... rebooting the brain’s control circuits in hours, not weeks.

A full circuit rewrite that results in transformation.
3/ New neuroimaging just cracked something big:

18 studies. 440 patients. Total chaos in the results…
Until researchers found the pattern.

They mapped it all onto one brain circuit.

Ketamine doesn’t act everywhere.

It acts here: Image
Read 12 tweets

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