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Conor Browne Profile picture
@brownecfm
Aug 15 • 9 tweets • 2 min read • Read on X
1. As a consultant analyst that generally presents to the C-suite of organisations, I am often asked to produce short, concise explanations of both biological and geopolitical risks. Regarding Covid-19, I use the same summary with both C-level clients and friends:
2. SARS-CoV-2 is a pathogen that can cause both acute and chronic disease. Vaccination reduces the severity of acute disease and the risk of developing chronic disease. However, current vaccines are insufficient to meaningfully reduce ongoing infection and transmission.
3. Since reinfection with SARS-CoV-2 is the norm, and the risk of developing chronic disease following infection is always present, regardless of how many infections an individual has had, it is inevitable that chronic disease will increase at the global population level.
4. Mass and ongoing infection with SARS-CoV-2 also adversely affects the immune landscape of the global population, primarily manifested by pathogen - pathogen interaction (the severity of both dengue and malaria is increased by prior SARS-CoV-2 infection, for example):
5. COVID-19 infection and its association with severe malaria & dengue: an epidemiological study from Southern India - PMC share.google/TdFwV7WvtKaB7N…
6. As such - and it really is stating the obvious here - ongoing global population infection with SARS-CoV-2 will make the world sicker, through both infection-induced chronic disease and pathogen-pathogen interaction.
7. The reason this is not being addressed in any meaningful way - and, in fact, why in some countries Covid-19 is effectively being retconned, is because of the (understandable) unpopularity of both non-pharmaceutical interventions and vaccine mandates in 2020 and 2021.
8. This unpopularity has been utilised by political parties seeking to either gain or maintain power. In doing so, an alignment has been created between politics, powerful vested interests, and anti-science ideologies. This alignment perpetuates and increases the risks of Covid.
9. /end

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More from @brownecfm

Conor Browne Profile picture
Aug 10
1. I've said exactly this for quite some time. Expanding on Adrian's point here, Covid-19 has three distinct characteristics as a disease that enables it to be denied at a societal level.
2. First, none of its symptoms trigger the human disgust mechanism. Adrian gives a great example of this. The two key symptoms that distinguish Covid-19 from other common diseases are cognitive dysfunction and anosmia, both of which are *invisible* to other people.
3. In simulations I took part in long before the Covid-19 pandemic, diseases with symptoms that triggered the human disgust mechanism - symptoms such as disfigurement, vomiting, incontinence, bleeding, and convulsive syncope - were most likely to cause people to avoid infection.
Read 11 tweets
Conor Browne Profile picture
Aug 4
1. A recent conversation with a colleague threw into sharp relief exactly why I am so inspired to develop technologies to prevent pathogenic infection. So, if you'll indulge me, let me explain. In early 2002, I had what to all intents and purposes was a cold. Sniffles, cough etc.
2. I just took paracetamol and got on with it, and was completely fine in a few days. About a week later, I suddenly developed widespread and extensive muscle twitching - fasciculations. These fasciculations got severe really quickly, enough to cause chronic insomnia.
3. It's difficult to sleep with widespread muscle twitching, I assure you. These symptoms eventually led me to a neurologist, who diagnosed me with cramp-fasciculation syndrome (CFS). Later, another neurologist considered neuromyotonia to be a more accurate diagnosis.
Read 13 tweets
Conor Browne Profile picture
Jul 29
1. The most important concept in this excellent article is this:

'the team wanted to explore what he called a “*reciprocal relationship*” between COVID-19 and chronic conditions'.

* my emphasis
oregonlive.com/health/2025/07…
2. “If you had already had metabolic disease, like obesity, diabetes or hypertension, that meant that if you got COVID, it was going to be worse,” he explained. “On the other hand, there was a potential risk of new-onset metabolic disease after COVID.”
3. This reciprocal relationship is why unmitigated SARS-CoV-2 transmission will inexorably lead to decreasing population health, especially when you also consider that a new-onset metabolic disease *caused* by SARS-CoV-2 infection could be made *worse* by subsequent re-infection.
Read 4 tweets
Conor Browne Profile picture
Jul 14
1. Allow me to clarify, beginning with a definition: by 'rigorous indoor masking' I mean 'wearing a mask in all indoor public spaces'. This, of course, means no eating, although hydration is possible using a sip valve.
2. Why do I write that it can be really difficult? Because acknowledging the sacrifices that people have made as a result of rigorous masking - some for over five years now - to protect both themselves and others is very important.
3. Recognising hardship that people have embraced and continue to embrace for the good of themselves and others lets those people know that their hardship is both seen and appreciated. It is a validation of their efforts. Any leader will tell you how vital this is.
Read 10 tweets
Conor Browne Profile picture
Jul 13
1. Outstanding summary of a recently published study on cognitive dysfunction in Long Covid (link to study at end of thread). The important point here is the 20% prevalence of anosognosia: having cognitive dysfunction but not being aware of it.
2. This was also a finding of the SARS-CoV-2 Human Challenge Study.

From the Discussion: 'This apparent discrepancy between objective and subjective measures could be interpreted as indicating that the tasks are sensitive enough to detect small...
share.google/sh8p64mCjstfgX…
3... changes in cognition that are *too subtle for the volunteer to be metacognitively aware of*'

*my emphasis.

A growing percentage of the global population with cognitive dysfunction that they are not aware of will insidiously change human society.
Read 4 tweets
Conor Browne Profile picture
Jun 27
1. The prevailing discourse surrounding mitigating against SARS-CoV-2 infection is rife with false dichotomies. At a societal level, the most obvious of these is the notion that mitigation measures stand in opposition to economic growth, when, in fact, the opposite is true:
2. Mitigation measures - specifically widespread air filtration or purification - would increase economic growth, by virtue of reducing ill health in the workforce (implementing widespread passive mitigations would also increase operational resilience to future pandemics).
3. Likewise, at a personal level, the prevailing false dichotomy is that mitigating against infection is incompatible with human flourishing. This is also not the case, on two levels:
Read 8 tweets

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