Simon Maechling Profile picture
Aug 15 10 tweets 2 min read Read on X
The US just cancelled US$500 million in mRNA research grants.

In 2025.

For a technology that saved millions of lives.

That’s not caution.
That’s cutting off your nose to spite your face. 🧵👇1/ Image
mRNA isn’t just a COVID-19 vaccine trick.

It’s a flexible platform that’s being tested for cancer, autoimmune diseases, and inherited conditions like sickle cell.

Shutting down research now? That’s science backwards. 2/
This move wasn’t a surprise.
It comes from a political playbook that’s replacing

science with ideology.
Removing independent experts. Slashing funding.

Undermining public trust.
That’s not governance. That’s sabotage. 3/
Meanwhile, the rest of the world is not following this dangerous path.

Countries are doubling down on mRNA, not walking away.

Why? Because they see it as key to pandemic readiness - and scalable biotech innovation. 4/
Make no mistake: every new technology has risks.

But mRNA vaccines have decades of safety and real-world outcomes behind them.

The benefits? Overwhelming. The risks? Manageable. 5/
And let’s not forget the scientific legacy here:

mRNA was born from US research - from Paul Krieg’s and Douglas Melton’s early synthesis to Karikó and Weissman’s Nobel-winning breakthroughs.

This was US leadership. Now they’re shrinking from it. 6/
Durable vaccine platforms don’t just sit idle.
They’re repurposed - continuously.

Shutting down mRNA research now means losing the best shot at future therapeutics.

That’s not caution. That’s obstruction. 7/
We need innovation ready for new diseases, future cancers, and fresh public-health challenges.

Cancelling mRNA research isn’t protection.

It’s a retreat.
And the world is watching. 8/
mRNA didn’t save us by accident.

It’s a product of relentless science, investment, and global collaboration.

Cancelling that fight? That’s a choice to let progress expire.

Let’s not stand for it. 9/

nature.com/articles/d4158…
How RFK Jr. alienated MAGA, MAHA and the White House in a single week.

The botched announcement about mRNA vaccines reveals a health department full of dysfunction and infighting. 10/

msnbc.com/news/news-anal…

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More from @simonmaechling

Aug 3
Hi, Chemist here 👋

Why do some people think synthetic mRNA is dangerous?

Because they’re told it’s “unnatural,” untested, or secretly rewriting their DNA.

Let’s break that down - with facts.
(Spoiler alert - it's not). 🧵👇 1/
“It’s synthetic!”

Yes. And?

So is paracetamol. So is insulin. So is your Wi-Fi.

Synthetic doesn’t mean dangerous.
It just means designed to work better. 2/
“It contains N¹-methylpseudouridine!”

Correct. A tweaked version of a base that’s already found in your body.

This minor change makes the mRNA:

More stable.
Less inflammatory.
Easier to read by ribosomes.

No magic. Just chemistry. 3/
Read 10 tweets
Aug 3
Pesticides are among the most misunderstood tools in society today.

Everyone talks about what they are.

Almost no one explains how they’re tested, regulated, and monitored.

Let’s fix that.

A thread on pesticide safety,
and the science behind it: 🧵1/
First: most people think "chemical = dangerous."

But science doesn’t work that way.
Risk ≠ Hazard.

Even water can be lethal at high enough doses.
What matters is how much and how often you're exposed.

That’s the core of toxicology.
It’s called “The dose makes the poison.” 2/
So how is pesticide safety actually assessed?
Before approval, a pesticide must undergo:

✅ Acute toxicity
✅ Carcinogenicity
✅ Endocrine disruption
✅ Reproductive studies
✅ Environmental impact
✅ Chronic exposure studies

Over 100+ scientific studies.
Per product. 3/
Read 9 tweets
Jul 26
For over a decade, anti-GMO activists demanded long-term studies in mammals.

Not mice.
Not rats.
Primates.

Well... scientists did just that.
And the results are in.

Let’s talk about a 7-year feeding study in macaques.
🧵 1/👇 Image
Researchers fed two generations of cynomolgus monkeys diets made of ~70% GM maize.

The maize carried:

🌽 cry1Ab and cry2Aj (Bt proteins — insect protection).

🌿 EPSPS (herbicide tolerance — glyphosate resistance).

Control groups ate non-GM or conventional maize. 2/
Monkeys were monitored across two generations, with detailed assessments of:

🧬 Immune status.
🧪 Blood chemistry.
🧠 Serum metabolites.

No shortcuts. This wasn’t a 90-day rat test.
This was 7+ years, cradle to adulthood. 3/
Read 10 tweets
Jul 25
We fear invisible chemicals.

But we ignore the ones we can see. The ones that actually harm us every single day.

Let’s talk about the visible poisons we breathe, burn, and touch… and why no one seems to care. 🧵1/
We panic over “glyphosate traces” in cereal.

Meanwhile, burning wood in your cozy fireplace fills your home with benzene, formaldehyde, and fine particulates that cause cancer.

Nobody panics. We call it “natural warmth.” 2/
We ban safe pesticides based on microgram exposure models.

But light up a cigarette? Suddenly it’s personal freedom - even though it releases 7,000+ chemicals, 70 of which are known carcinogens.

The poison is visible. The choice is deliberate. 3/
Read 11 tweets
Jul 4
The idea that everything we touch, breathe, or eat is slowly killing us sounds scary, right?

That’s the point.

I want to explain why this panic is manufactured - and what really matters for your health.👇🧵1/

thefirebreak.org/p/the-exposome…
The exposome is the new buzzword for an old idea:
That “chemicals” and “pollution” cause all our modern diseases.

Give it a scientific-sounding name and - boom - suddenly it’s a reason for new funding, new policies, and new fears. 2/
Did someone mention PFAS? Of course.

Also: microplastics, ultra-processed food, cancer, endocrine disruptors…

All wrapped into a neat story:
“We are drowning in toxins and nobody is safe.” 3/
Read 12 tweets
Jul 3
Every GMO debate ignores one simple fact:
You've almost never eaten a “natural” food in your life. 👇1/ Image
Corn?
Used to be a wild grass with hard kernels smaller than a fingernail.

Humans reprogrammed it over thousands of years.
The result? Modern corn.

A genetically modified organism. No lab needed. 2/
Wheat?
Originally dropped its seeds to the ground - impossible to harvest.

So early farmers selected mutants that didn’t.
Now wheat depends on us to reproduce.

That’s not natural. That’s engineering. 3/
Read 12 tweets

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