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Aug 24, 2025 12 tweets 4 min read Read on X
“Dopamine Nation by Dr. Anna Lembke”

What a phenomenal read. It unpacks the neuroscience of reward and in so doing, enable us to find a better, healthier balance between pleasure and pain.

From Dr. Andrew Huberman recommendations.

7 lessons from the book:Image
Dopamine was first identified as neurotransmitter in the human brain in 1957.

It is not only the neurotransmitter involved in reward processing, but it plays a bigger role in the motivation to get a reward than the pleasure of the reward itself.

Wanting more than liking. Image
High dopamine substances trigger the release of dopamine in our brain's reward pathway. Image
1) Pleasure and Pain are Co-Located:

Pleasure and pain are processed in overlapping brain regions and work via an opponent-process mechanism; they work like a balance.

It wants to remain level, in equilibrium. It does not want to be tipped for very long to one side or another. Image
2) Self-binding creates literal and metacongnitive space between desire and consumption, a modern necessity in our dopamine-overloaded world. Image
3) A key to well-being is for us to get off the couch and move our real bodies, not our virtual ones.

Exercise has a more profound and sustained positive effect on mood, anxiety, cognition, energy, and sleep than any pill. Image
4) Honesty Promotes Intimate Human Connections: Image
5) Prosocial shame affirms that we belong to the human tribe. Image
6) Instead of running away from the world, we can find escape by immersing ourselves in it. Image
7) The rewards of finding and maintaining balance are neither immediate nor permanent. They require patience and maintenance.

Healthy practices happen day by day. Image
For more of these, subscribe to my weekly newsletter “Learn, Unlearn and Relearn” on reading:

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