Stuart Phillips (he/him) Profile picture
Nov 2 5 tweets 2 min read Read on X
To be clear, the 27% added is lean mass, that's not muscle mass, and that added mass is 300g (less than a pound). So I think @fmfclips that I don't mean to be disingenuous, but @PeterAttiaMD's take on 'how much' protein is good is overblown!
I've spent 30 years working in this area, and we've generated lots (and lots) of data on protein requirements and hypertrophy-related requirements. The RDA isn't cutting it, but anything beyond 1.6 is a total waste of time (and money).
Many are having a heyday preaching BIG protein without data, nuance, or understanding of basic principles. I'd invite @BioLayne, @foundmyfitness, @PeterAttiaMD, @hubermanlab to sit down and have a REAL discussion about protein and muscle anytime!
And when I say real, I mean, backed and driven by data!

I've championed the 'protein won't kill you' message, too, but there's a real limit to the benefits. Moving beyond hyperbole would serve everybody.

sciencedirect.com/science/articl…
cdnsciencepub.com/doi/10.1139/ap…
Reality check on what protein CAN do and actually does (better stats and analysis than the Morton meta):


NOTES: FFM and lean mass are NOT muscle mass. Note that strength does not change even when lean mass does (is it even muscle?)onlinelibrary.wiley.com/doi/10.1002/jc…

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More from @mackinprof

Aug 21
Sometimes even the bigs get it wrong Image
In 2014, a Cell Metabolism paper claimed high protein intakes (50–65 y) ↑ mortality by 75% & ↑ cancer mortality 4-fold! Headlines screamed: “Protein as bad as smoking.” 🔗 a 🧵cell.com/cell-metabolis…
Our team of protein researchers saw major flaws in that NHANES analysis. We wrote a letter to the editor—it was never published. Thanks to @biolayne, it’s still alive.
🔗 biolayne.com/blog/broscienc…
Read 10 tweets
Oct 29, 2024
When analyzed, women gain the same relative amount of lean mass (and presumably muscle) and strength as men
sportrxiv.org/index.php/serv…
pubmed.ncbi.nlm.nih.gov/32218059/

So why all the fuss over T (total or free), as a causative factor in RT-induced hypertrophy?
Hormones, Hypertrophy, and Hype: An Evidence-Guided Primer on Endogenous Endocrine Influences on Exercise-Induced Muscle Hypertrophy

great work y @AlyshaDSouza1 and @vanevery93journals.lww.com/acsm-essr/full…
In short, mechanisms of hypertrophy are mostly internally driven intrinsic to the muscle itself Thanks @DrMikeRoberts

Short-term acute rises and menstrual cycle phase-based changes in hormones are not consequential to RT-induced hypertrophy.journals.physiology.org/doi/full/10.11…
Read 6 tweets
Oct 16, 2024
Cortisol, often known as the “stress hormone,” has traditionally been associated with muscle breakdown and fat gain, particularly in stressful situations. But is cortisol 'bad' impairing fat mass loss and lean mass gains? A 🧵...
Research suggests that this relationship may not be as clear-cut, particularly in the context of exercise and controlled conditions. Studies have shown that cortisol does not significantly impede muscle mass gains or contribute to fat mass accumulation under certain conditions.
A study published in the European Journal of Applied Physiology observed that although cortisol levels rise following intense resistance training, these increases do not seem to inhibit muscle growth or strength gains.
Read 13 tweets
Sep 10, 2024
Muscle matters: the effects of medically induced weight loss on skeletal muscle thelancet.com/journals/landi…
Some believe muscle loss isn't important in drug-induced weight loss. We @DrCarlaPrado beg to differ.

No trial to date has assessed long-term changes in mobility or MSK health once people stop taking the drug (and regain fat)
Older patients with my comorbidities could be especially vulnerable.

Sarcopenic obesity is the confluence of two syndromes and conditions that could exacerbate many disorders. So, attention needs to be paid to minimizing muscle loss.
Read 6 tweets
Jul 3, 2024
You're going to want to bookmark this...

DJ Kidney... another one, another one...

Association between dietary protein intake and risk of chronic kidney disease: a systematic review and meta-analysis
frontiersin.org/journals/nutri…
The data showed a lower CKD risk significantly associated higher-level dietary total, plant or animal protein (especially for fish and seafood) intake.
More...

These data further indicate that, at least in the short term, higher protein intake within the range of recommended intakes for protein is consistent with normal kidney function in healthy individuals.sciencedirect.com/science/articl…
Read 9 tweets
Feb 26, 2024
Recently an article got everyone's knickers in a twist about protein and CVD. Here's an easy to read summary of the paper with my pictorial essay medicalnewstoday.com/articles/eatin…
Note: this is a conclusion from mice only... it's translation to humans... 🧐 Image
High protein diets may contribute (!!) but we should revise dietary guidelines (???) In our 2020 paper also in mice 🐭 🤨 Image
Read 11 tweets

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