Dr Nilesh Nolkha Profile picture
Nov 12 9 tweets 3 min read Read on X
Tweet 1 🌀 Rheumatoid Arthritis (RA) Flares — This is for all rheumatoid arthritis patients and caregivers. Please discuss with your doctor and don’t follow this blindly as medical advice.

🌀 What exactly is a Rheumatoid Arthritis (RA) flare?
It’s when your joints become more painful, swollen, warm, or stiff than usual — sometimes with fatigue or low energy.
Flares can be mild or severe, short or long. They may strike without any clear reason.
#RheumatoidArthritis #RAflare #NirjaraMultispecialityClinic #NileshNolkha #FreedomFromPainDr nilesh Nolkha, rheumatoid arthritis
Tweet 2 🔀 Types of Flares Seen in Rheumatoid Arthritis:
1️⃣ 🔥 Palindromic / Single-joint flare – sudden, severe pain, often immobilizing.
2️⃣ 🌧️ Subtle multi-joint flare – swelling and stiffness in several joints.
3️⃣ 🌪️ Generalized flare – multiple joints flare together, disabling and painful.
Sometimes, what looks like a flare has no identifiable reason.

#Rheumatology #RAflare #NirjaraMultispecialityClinic #NileshNolkha
Tweet 3
📊 How common are Rheumatoid arthritis flares?
Nearly every person with RA has flares at some point.
In long-term studies, more than 90–99 % of patients experienced at least one flare within three years — even on good medicines.
👉 This does not mean treatment failed. It means RA can act unpredictably at times.
#RheumatoidArthritis #Rheumatology #NirjaraMultispecialityClinic #NileshNolkha
Tweet 4
What usually triggers a rheumatoid arthritis flare?
•💊 Missed or irregular medication (one of the most common and consistent reasons which patients often fail to acknowledge)
•Infections 🦠
•Stress or fatigue 😥
• Heavy physical exertion
•Weather ☁️ (sometimes)
🍋 Food like sour or protein-rich meals rarely cause flares (often food is given most undue blame for flares) — those links are mostly myths.
Every patient is different, and most flares make no sense at all.
#RheumatoidArthritis #ArthritisMyths #NirjaraMultispecialityClinic #NileshNolkha
🧭 Tweet 5
What should you do if you are having flare of rheumatoid arthritis ?

•Use your doctor-approved “flare plan” (e.g., NSAID or short Prednisolone course).
•Rest, apply gentle warmth, stay hydrated, and record your symptoms.
•Tell your rheumatologist if flares repeat or last longer. Not every pain is inflammation – sometimes it’s fibromyalgia-like pain, needing a different approach.

#RheumatoidArthritis #RAflare #NirjaraMultispecialityClinic #NileshNolkha #FreedomFromPainnilDr nilesh nolkha
Tweet 6
We have a flare plan given to all our rheumatoid arthritis patients (Please discuss with your doctor and don’t follow this as medical advice.)

For Mild to Moderate Flare Pain
Use one of NSAID (you can use any per your choice ) as advised:
Eg
• Naproxen 500 mg twice daily 🕘 or
• Diclofenac 50 mg two–three times daily 💊 or
• Etoricoxib 90 mg once daily 🌙 or
Etc

Take after food, for short duration 1-3 days only. Don’t stop your regular RA meds.
#RheumatoidArthritis #Rheumatology #NirjaraMultispecialityClinic #NileshNolkha

For Severe or Palindromic Flares (if reasonably sure of no clear infection)
If pain is unbearable or disabling we can use steroids as below :
• Take Prednisolone (Wysolone) 20–40 mg/day for 1–3 days 🩺 (as thought by many no clear slow tapering required for acute very short period steroid doses)
• If still severe, Dynapar injection SOS can be given by a local doctor/nurse 💉
• Occasionally, a Depo-Medrol injection may help for longer relief.
All are part of your pre-planned “flare pack.”

If you have regular severe unbearable flares requiring steroids inform your doctor. Patients need to monitor infections, sugars and blood pressure on above medications.
#RheumatoidArthritis #RAflare #NirjaraMultispecialityClinic #NileshNolkha
Tweet 7
To summarise on how to tackle flare in rheumatoid arthritis patients

1) Flares are often very painful and often random with no relation to any constant factor in most

2) Missing or irregular medicines (often most common) and heavy exertion may be most consistent causes of rheumatoid flares

3) Always have ready made plan for flares from your rheumatologist. Inform them if flares are recurrent.
#RheumatoidArthritis #Rheumatology #NirjaraMultispecialityClinic #NileshNolkha
@DrAkhilX @DrSamB21 @IlliasulK @DurgaPrasannaM1 @Rheumat_Aravind 👆
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More from @nileshnolkha

Oct 14
🧵 Read this if you have knee pain and are 35–40+ 👇

#KneePain #KneeOsteoarthritis #DrNileshNolkha #NirjaraMultispecialityClinic #FreedomFromPain #NIRJARA



1️⃣ What exactly is Knee Osteoarthritis? 🦵
It’s not just age or “wear & tear.”
Osteoarthritis = cartilage thinning + bone changes + low-grade inflammation + muscle weakness.
🎯 It’s a whole-joint condition—mechanical + metabolic. (Nature Rev Rheumatol 2023)
2️⃣ Why “wear & tear” in knee pain is oversimplified ⚙️?
📊 Studies show obesity doubles the risk (OR ≈ 2.18). (Obesity Reviews 2015)
💪 Weak thigh muscles raise OA risk by ~1.6×. (Arthritis Care Res 2015)
So it’s not age alone—it’s load + inactivity + inflammation.
3️⃣ Why early strengthening helps 💪🦵in knee pain or early knee osteoarthritis?
Stronger quadriceps & glutes act like shock absorbers for your knee.
🏋️ Resistance training improves pain, strength & daily function in knee OA. (PMCID: PMC11676110)
Even 10 min/day → big difference in comfort & mobility.
Read 5 tweets
Oct 7
Knee replacement
Indian context

🧵 1/12 — Not every knee pain needs a Knee Replacement… and waiting too long can also be a mistake.

#KneeReplacement #FreedomFromPain #NirjaraMultispecialityClinic #NileshNolkha
2/12 — When Knee Replacement truly helps
✅ Severe knee arthritis with daily pain and progressive decrease in mobility
✅ Pain affecting walking, stairs, sleep, or work
✅ No benefit from medicines, exercises, or injections
At that point, Knee Replacement can restore quality of life.
#KneeReplacement #FreedomFromPain #NirjaraMultispecialityClinic
3/12 — When NOT to go for Knee
❌ inadequate trial of conservative therapy, rehab, exercises
❌ Pain all over the body (like fibromyalgia)
❌ Inflammatory arthritis (RA, PsA) not under control
❌ No trial of structured physiotherapy or diet improvement
❌ No post-surgery rehab plan or family support
❌ Excess weight is an issue

Neither of this may be an absolute contraindication
#KneeReplacement #NileshNolkha #FreedomFromPain
Read 12 tweets
Sep 21
Read if you want to understand the framework of rheumatology / medicine diagnosis and practice

🧵 How to Approach a Patient of Connective Tissue Disease in Real Life – Lessons from a 68-Year-Old Case

1/ A 68F presented with severe hand arthritis, neck & foot pain.
She had failed MTX, HCQ, Leflunomide, Sulfasalazine + Steroids. Being treated for almost 9 months.
USG: Tenosynovitis with vascularity → confirmed inflammation.
But autoantibody profile didn’t match neatly.

#MedTwitter #NileshNolkha #FreedomFromPainImage
Mismatch Between Antibodies & Clinical Phenotype – What Do We Do?

2/
•ANA 2+ positive
•CENP A/B positive (suggesting CREST)
•Anti-CCP negative
•Mild dry eye, no Raynaud’s, no mouth dryness, no skin fibrosis or digital pits or psoriasis

👉 Possible Sjögren’s overlap
👉 Best working label = Undifferentiated CTD with arthritis-predominant disease

#MedTwitter #NileshNolkha #FreedomFromPain
CTD Management is Domain-Driven – Every Patient is Different

3/ In CTD, therapy depends on the dominant manifestation:
•Arthritis → MTX, Leflunomide, JAK inhibitors, Biologics
•ILD → MMF, Cyclophosphamide, Rituximab, Nintedanib
•PH → PDE5i, Endothelin antagonists, Prostacyclins
•Nephritis → MMF, CYC, Rituximab, Belimumab

📌 One label ≠ one treatment.

#MedTwitter #NileshNolkha #FreedomFromPain
Read 6 tweets
Aug 22
🧵 Hydroxychloroquine - HCQ- Masterclass : One Drug, Many Uses – Safe, Practical & Powerful 💊

This can be read by both patients and doctors

1/
💊 Hydroxychloroquine (HCQ) is a cornerstone DMARD in rheumatology.
It’s slow-acting but offers:
✅ Immunomodulation
✅ Steroid-sparing benefit
✅ Metabolic perks
✅ Safety in long-term use

Let’s break down how to use it wisely 🧠
#RheumTwitter #medtwitter
#hydroxychloroquine #hcq
#HCQMasterclass #rheumatoidarthritis #lupus
2/
🔍 Where is HCQ most used in rheumatology?
•🦋 Systemic Lupus Erythematosus (SLE)
•🤲 Rheumatoid Arthritis
•💧 Sjogrens disease
•🧬 Antiphospholipid Syndrome (APS)
•🌞 Cutaneous LE, Dermatomyositis

#RheumTwitter #medtwitter
#hydroxychloroquine #hcq
3/
🌐 niche uses of HCQ:
•Sarcoidosis (skin, joint)
•Lichen planus ?
•Porphyria cutanea tarda
•Post-viral arthritis
•Palindromic rheumatism
•Fatigue-dominant systemic diseases (CTD)
💡 Useful beyond guidelines.
#RheumTwitter #medtwitter
#hydroxychloroquine #hcq
Read 15 tweets
Aug 14
🧵 ANA Testing in Rheumatology — Masterclass for Doctors & MedTwitter

1/ 📢 What’s ANA?
ANA = Anti-Nuclear Antibodies.
It’s a surrogate marker for >50 nuclear antigens (Ro, Sm, dsDNA, La, Scl-70, etc).
✅ Can be positive in many CTDs
❌ Positive ≠ disease
❌ Negative ≠ rule out all CTDs.Image
2/ 🧪 When NOT to order ANA
•No symptoms/signs of CTD
•Only “screening” due to anxiety or family history
•Non-specific aches/fatigue without other red flags
🔑 Always pair ANA with a clinical question.
3/ 📊 Pre-test probability is king!
Low pre-test probability = higher chance of false positives.
30% of healthy people may have positive ANA.
Use clinical context before interpreting.
I Image
Read 20 tweets
Aug 6
🧵 Why do I keep getting gout attacks despite treatment?
Let’s bust the myths and explain the science 👇
#Gout #RheumatologySimplified #RefractoryGout #GPUpdate #UricAcid Image
1️⃣
💥 “Doc, I take meds. I stopped alcohol. I even eat tart cherries & turmeric capsules…
…Then WHY AM I STILL GETTING GOUT ATTACKS?”

📍 This is what we call uncontrolled or refractory gout.
Let’s break down why this happens 👇
2️⃣
🎯 #1: Uric acid target not achieved
Even if you’re on meds like Allopurinol or Febuxostat, you may NOT be at goal.

✅ Target = Uric acid < 6 mg/dl
📉 Not just normal. We want it low enough to stop crystal formation.
#ReachForSix Image
Read 11 tweets

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